DCHS1 Gene

HGNC Family	Cadherins
Name	dachsous cadherin-related 1
Description	This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Dachsous1 (DCHS1) is an atypical cadherin that, by acting as the receptor for FAT4, plays a central role in coordinating cell polarity, proliferation, and differentiation during development. In the developing cerebral cortex, for example, reduction or mutation of DCHS1 disrupts the balance of neural progenitor proliferation and differentiation—mechanisms that operate upstream of Hippo signaling effectors such as YAP—resulting in malformations like periventricular neuronal heterotopia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the mouse, gene‐targeted mutation analyses have shown that DCHS1 cooperates with FAT4 to regulate planar cell polarity and tissue morphogenesis in multiple organs including the ear, kidney, intestine, heart, lung, and skeleton"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "; similar complementary expression patterns of Dchs1 and partner genes in organs such as kidney, lung, and intestine further support its conserved role in planar polarity regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the embryonic cerebral cortex, Fat4 and Dachsous1 colocalize at specific apical membrane regions of neural progenitor cells to help organize membrane architecture—a function that is crucial for proper cortical development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, studies in the kidney have revealed that stromal FAT4 engages DCHS1 on nephron progenitors to restrict their self‐renewal, thereby ensuring a balanced formation of the condensing mesenchyme, while related investigations demonstrate that Dchs1 mutations lead to disorganized cap mesenchyme and impaired nephron morphogenesis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, structural studies indicate that DCHS1—as part of the Fat–Dachsous cadherin complex—features kinked, flexible ectodomains that likely facilitate its function in the confined intercellular spaces where it mediates adhesive interactions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " The DCHS1–FAT4 axis is also required in the mesenchyme to drive cellular clustering during intestinal villus formation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "and in determining skeletal shape through control of cell intercalation during sternum condensation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In the lymphatic vasculature, disruption of Dachsous1 signaling contributes to defective valve morphogenesis, providing a mechanistic link to lymphedema seen in syndromes such as Hennekam."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, genetic studies have extended the spectrum of DCHS1 function to vertebral development, where the Fat4–Dchs1 pathway modulates proliferation in the sclerotome, and to osteoblast differentiation in craniofacial morphogenesis, with mutations in these genes underlying syndromes such as Van Maldergem"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "and affecting bone formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Synthetic biology approaches further demonstrate that localized feedback mechanisms enabled by stable Fat4–Dchs1 complexes are sufficient to generate planar cell polarity in mammalian cells"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", while human studies linking mutations in DCHS1–FAT4 to altered cerebral lateralization emphasize its importance in coordinating left–right differences in the cortex."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Finally, variants in DCHS1 and related protocadherins have been implicated in pituitary developmental defects, highlighting its broader contribution to hypothalamic–pituitary morphogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings underscore the multifaceted role of DCHS1 as a key mediator of intercellular signaling and structural organization during the development of diverse organ systems.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Silvia Cappello, Mary J Gray, Caroline Badouel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.2765"}], "href": "https://doi.org/10.1038/ng.2765"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24056717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24056717"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yaopan Mao, Joanna Mulvaney, Sana Zakaria, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.057166"}], "href": "https://doi.org/10.1242/dev.057166"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21303848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21303848"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rebecca Rock, Sabrina Schrauth, Manfred Gessler "}, {"type": "b", "children": [{"type": "t", "text": "Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.20515"}], "href": "https://doi.org/10.1002/dvdy.20515"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16059920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16059920"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Takashi Ishiuchi, Kazuyo Misaki, Shigenobu Yonemura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200811030"}], "href": "https://doi.org/10.1083/jcb.200811030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19506035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19506035"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Mazdak Bagherie-Lachidan, Antoine Reginensi, Qun Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.122648"}], "href": "https://doi.org/10.1242/dev.122648"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26116661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26116661"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yaopan Mao, Philippa Francis-West, Kenneth D Irvine "}, {"type": "b", "children": [{"type": "t", "text": "Fat4/Dchs1 signaling between stromal and cap mesenchyme cells influences nephrogenesis and ureteric bud branching."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.122630"}], "href": "https://doi.org/10.1242/dev.122630"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26116666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26116666"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yoshikazu Tsukasaki, Naoyuki Miyazaki, Atsushi Matsumoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Giant cadherins Fat and Dachsous self-bend to organize properly spaced intercellular junctions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1418990111"}], "href": "https://doi.org/10.1073/pnas.1418990111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25355906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25355906"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Abilasha Rao-Bhatia, Min Zhu, Wen-Chi Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2020.02.003"}], "href": "https://doi.org/10.1016/j.devcel.2020.02.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32155439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32155439"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yaopan Mao, Anna Kuta, Ivan Crespo-Enriquez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dchs1-Fat4 regulation of polarized cell behaviours during skeletal morphogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms11469"}], "href": "https://doi.org/10.1038/ncomms11469"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27145737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27145737"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Francoise Pujol, Tina Hodgson, Ines Martinez-Corral, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.117.309818"}], "href": "https://doi.org/10.1161/ATVBAHA.117.309818"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28705793"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28705793"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Anna Kuta, Yaopan Mao, Tina Martin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.131037"}], "href": "https://doi.org/10.1242/dev.131037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27381226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27381226"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ivan Crespo-Enriquez, Tina Hodgson, Sana Zakaria, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dchs1-Fat4 regulation of osteogenic differentiation in mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.176776"}], "href": "https://doi.org/10.1242/dev.176776"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31358536"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31358536"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Olga Loza, Idse Heemskerk, Nadav Gordon-Bar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A synthetic planar cell polarity system reveals localized feedback on Fat4-Ds1 complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.24820"}], "href": "https://doi.org/10.7554/eLife.24820"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28826487"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28826487"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Christian Beste, Sebastian Ocklenburg, Maja von der Hagen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mammalian cadherins DCHS1-FAT4 affect functional cerebral architecture."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Struct Funct (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00429-015-1051-6"}], "href": "https://doi.org/10.1007/s00429-015-1051-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25930014"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25930014"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Emily J Lodge, Paraskevi Xekouki, Tatiane S Silva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.134310"}], "href": "https://doi.org/10.1172/jci.insight.134310"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33108146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33108146"}]}]}]}
Synonyms	CDHR6, VMLDS1, MVP2, CDH25, FIB1, CDH19, PCDH16
Proteins	PCD16_HUMAN
NCBI Gene ID	8642
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DCHS1 has 6,190 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 117 datasets.

Click the + buttons to view associations for DCHS1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DCHS1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by DCHS1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DCHS1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DCHS1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DCHS1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DCHS1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DCHS1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DCHS1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DCHS1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DCHS1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DCHS1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of DCHS1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DCHS1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DCHS1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DCHS1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DCHS1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DCHS1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DCHS1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with DCHS1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with DCHS1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DCHS1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DCHS1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing DCHS1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DCHS1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DCHS1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DCHS1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with DCHS1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with DCHS1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with DCHS1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of DCHS1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by DCHS1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving DCHS1 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DCHS1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DCHS1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with DCHS1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DCHS1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DCHS1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DCHS1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing DCHS1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with DCHS1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of DCHS1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.