DDA1 Gene

Name	DET1 and DDB1 associated 1
Description	Involved in protein polyubiquitination. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DDA1 is an evolutionarily conserved regulatory component of Cullin‐4 (CRL4) ubiquitin ligase complexes that plays multifaceted roles in targeted protein degradation and the maintenance of cellular homeostasis. Structural analyses have revealed that DDA1 is an integral part of CRL4 assemblies—stabilizing substrate receptor modules such as DCAF15—to facilitate the molecular glue–mediated recruitment and subsequent proteasomal degradation of factors like the splicing regulator RBM39."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In addition, DDA1 is described as a chromatin‐associated core subunit of multiple CRL4 complexes, where its loss leads to genomic instability and double‐stranded DNA breaks, underscoring its role in preserving genome integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In mammalian cells, DDA1 also partners with DET1 and DDB1 to form regulatory complexes that modulate CRL4 activity, as evidenced by its role in controlling substrate degradation in both normal signaling and stress‐responsive pathways—for example, in the degradation of abscisic acid receptors in plants"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "and in Arabidopsis where it contributes to hormonal regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, aberrant overexpression of DDA1 has been linked to oncogenic processes. Elevated DDA1 levels promote cell cycle progression and proliferation in various cancers, including lung and colon cancer, by modulating cyclin expression and activating signaling pathways such as NFκB, as well as in acute myeloid leukemia via interactions with microRNA networks."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "10"}]}, {"type": "t", "text": " Finally, DDA1-containing CRL4 complexes are also exploited by viral proteins to manipulate host cell cycle checkpoints and immune responses, highlighting the broader significance of DDA1 in disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these studies emphasize that DDA1 functions as a versatile adaptor/substrate receptor within CRL4 machinery. Its central role in orchestrating targeted protein degradation across diverse biological contexts makes it a promising biomarker and potential therapeutic target in cancer, viral infections, and beyond.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dirksen E Bussiere, Lili Xie, Honnappa Srinivas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Chem Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41589-019-0411-6"}], "href": "https://doi.org/10.1038/s41589-019-0411-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31819272"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31819272"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tyler B Faust, Hojong Yoon, Radosław P Nowak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Chem Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41589-019-0378-3"}], "href": "https://doi.org/10.1038/s41589-019-0378-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31686031"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31686031"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xinlin Du, Oleg A Volkov, Robert M Czerwinski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2019.10.005"}], "href": "https://doi.org/10.1016/j.str.2019.10.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31693911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31693911"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Michael Hans Olma, Marcia Roy, Thierry Le Bihan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.043539"}], "href": "https://doi.org/10.1242/jcs.043539"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19295130"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19295130"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Elah Pick, On-Sun Lau, Tomohiko Tsuge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.02432-06"}], "href": "https://doi.org/10.1128/MCB.02432-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17452440"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17452440"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "María Luisa Irigoyen, Elisa Iniesto, Lesia Rodriguez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeted degradation of abscisic acid receptors is mediated by the ubiquitin ligase substrate adaptor DDA1 in Arabidopsis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Plant Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1105/tpc.113.122234"}], "href": "https://doi.org/10.1105/tpc.113.122234"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24563205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24563205"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lin Cheng, Qianmei Yang, Can Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DDA1, a novel oncogene, promotes lung cancer progression through regulation of cell cycle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13084"}], "href": "https://doi.org/10.1111/jcmm.13084"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28211159"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28211159"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Senlin Zhao, Huamei Tang, Dongwang Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DDA1 promotes stage IIB-IIC colon cancer progression by activating NFκB/CSN2/GSK-3β signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7847"}], "href": "https://doi.org/10.18632/oncotarget.7847"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26942699"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26942699"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Qun Li, Jianmin Wang "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA TUG1 Regulates Cell Viability and Death by Regulating miR-193a-5p/Rab10 Axis in Acute Myeloid Leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S234935"}], "href": "https://doi.org/10.2147/OTT.S234935"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32103996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32103996"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "J Liu, T Li, X-L Liu "}, {"type": "b", "children": [{"type": "t", "text": "DDA1 is induced by NR2F6 in ovarian cancer and predicts poor survival outcome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2017)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28387912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28387912"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jayme Salsman, Madhav Jagannathan, Patrick Paladino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.05442-11"}], "href": "https://doi.org/10.1128/JVI.05442-11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22072767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22072767"}]}]}]}
Synonyms	C19ORF58, PCIA1
Proteins	DDA1_HUMAN
NCBI Gene ID	79016
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DDA1 has 5,466 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 108 datasets.

Click the + buttons to view associations for DDA1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DDA1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DDA1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DDA1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DDA1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DDA1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DDA1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DDA1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DDA1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DDA1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DDA1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of DDA1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DDA1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DDA1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with DDA1 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DDA1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DDA1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DDA1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing DDA1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DDA1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing DDA1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing DDA1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DDA1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DDA1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DDA1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DDA1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with DDA1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with DDA1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of DDA1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by DDA1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with DDA1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with DDA1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DDA1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DDA1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DDA1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with DDA1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DDA1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DDA1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DDA1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing DDA1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with DDA1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing DDA1 from the GeneSigDB Published Gene Signatures dataset.