{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DDX10 is a member of the DEAD‐box RNA helicase family that plays multifaceted roles in RNA metabolism and ribosome biogenesis, and its dysregulation has been implicated in various human diseases. In hematologic malignancies, DDX10 is found as the C‐terminal partner in NUP98 fusion proteins. The resulting NUP98–DDX10 chimeras enhance proliferation and self‐renewal of hematopoietic progenitors by misregulating transcriptional programs, with the conserved DEAD-box motif being essential for ATP and RNA binding activities that underpin the transforming capacity of the fusion – a function that appears critical for leukemogenesis ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "]."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In solid tumors, DDX10’s role appears to be context dependent. Elevated expression in osteosarcoma, lung cancer, chondrosarcoma/glioma, and colorectal cancer correlates with increased cell proliferation, invasion, and migration, with evidence suggesting that DDX10 can promote tumorigenic signaling pathways (including MAPK activation) and may function via interaction with factors such as IMP4 and modulation of E2F target genes ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "7"}]}, {"type": "t", "text": "]."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Conversely, in ovarian cancer DDX10 is epigenetically silenced by miR‐155–5p, and its reduced expression appears to promote tumor cell proliferation through deregulation of the Akt/NF–κB pathway, suggesting a possible tumor‐suppressive role in this context ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "]."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, DDX10 has been implicated in neurodegenerative processes; its interaction with α–synuclein leads to mislocalization from the nucleolus and stabilization of oligomeric species, thereby linking defects in nucleolar function with α–synuclein–mediated toxicity ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "]. \n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore that DDX10 can contribute to oncogenesis—either as an oncogenic driver when present in fusion proteins or via overexpression in certain solid tumors—and may also play roles in neuronal protein homeostasis. Its molecular functions, governed by conserved helicase domains, are critical for both normal ribosome assembly and the aberrant transcriptional and signaling programs observed in disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Johannes Schmoellerl, Inês Amorim Monteiro Barbosa, Thomas Eder, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "DDX10 promotes the proliferation and metastasis of colorectal cancer cells via splicing RPL35."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-022-02478-1"}], "href": "https://doi.org/10.1186/s12935-022-02478-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35109823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35109823"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Muhuizi Gai, Qifang Bo, Lixia Qi "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic down-regulated DDX10 promotes cell proliferation through Akt/NF-κB pathway in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.12.069"}], "href": "https://doi.org/10.1016/j.bbrc.2015.12.069"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26713367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26713367"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Blagovesta Popova, Dan Wang, Christina Pätz, et al. 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