DDX11 Gene

HGNC Family	DEAD box polypeptides (DDX)
Name	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
Description	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DDX11 (also known as ChlR1) is an iron–sulfur cluster–containing DNA helicase that plays several critical roles in genome stability. Initial genetic‐mapping studies identified DDX11 as a promising candidate gene for the regulation of telomere length, suggesting that it may influence chromosomal assembly and cellular senescence."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Subsequent investigations established that DDX11 is essential for proper sister chromatid cohesion; its depletion in human cells or its genetic ablation in mouse models results in chromosome segregation defects, cohesion loss, and even embryonic lethality accompanied by placental malformation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": " Biochemical analyses further demonstrate that DDX11 exhibits DNA-dependent ATPase and helicase activities with defined substrate specificities – for example, efficient unwinding requires a 5′ single-stranded DNA tail, and the helicase shows a marked preference for resolving noncanonical DNA structures such as triplexes and G-quadruplexes, which if not properly resolved can impede replication fork progression and chromatin organization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of DNA replication, DDX11 coordinates with fork protection proteins, notably Timeless, to promote processive unwinding and ensure efficient sister chromatid cohesion during S phase. Direct interactions between DDX11 and Timeless enhance both DNA binding and helicase activity, supporting replication fork progression even in the presence of replication‐stress–induced secondary DNA structures."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "9"}]}, {"type": "t", "text": " Moreover, failures in DDX11 function—as observed in patients carrying mutations that impair its DNA binding and ATPase activities—translate into defective DNA repair responses, particularly in the repair of interstrand crosslinks, and contribute to the pathogenesis of Warsaw breakage syndrome (WABS) characterized by growth retardation, microcephaly, hearing loss, and intellectual disability."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Regulatory layers further modulate DDX11 functionality. Long noncoding RNAs – such as CONCR and DDX11 antisense RNA 1 (DDX11‐AS1) – interact with and regulate DDX11 activity, thereby impacting sister chromatid cohesion and contributing to cellular proliferation, DNA replication, and tumor progression in diverse cancers including melanoma, hepatocellular carcinoma, colorectal cancer, gastric cancer, osteosarcoma, and esophageal squamous cell carcinoma."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "20"}]}, {"type": "t", "text": " In addition, transcription factors such as JunB and E2F1 have been implicated in the modulation of DDX11 expression, thereby influencing its role in ensuring proper chromatid cohesion and genomic integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}, {"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": " Collectively, these studies underscore that DDX11 is a pivotal component of the DNA replication machinery and chromosomal maintenance system—its helicase activity is essential for resolving secondary DNA structures, coupling replication with cohesion establishment, and safeguarding genome stability. Disruptions in DDX11 function not only underlie rare genetic disorders such as WABS but also contribute to oncogenic processes through promotion of chromosomal instability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mariuca Vasa-Nicotera, Scott Brouilette, Massimo Mangino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mapping of a major locus that determines telomere length in humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/426734"}], "href": "https://doi.org/10.1086/426734"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15520935"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15520935"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Joanna L Parish, Jack Rosa, Xiaoyu Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.03262"}], "href": "https://doi.org/10.1242/jcs.03262"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17105772"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17105772"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Andrea Farina, Jae-Ho Shin, Do-Hyung Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M802696200"}], "href": "https://doi.org/10.1074/jbc.M802696200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18499658"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18499658"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Akira Inoue, Tongyuan Li, Sarah K Roby, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.6.13.4411"}], "href": "https://doi.org/10.4161/cc.6.13.4411"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17611414"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17611414"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Manhong Guo, Kristian Hundseth, Hao Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A distinct triplex DNA unwinding activity of ChlR1 helicase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.634923"}], "href": "https://doi.org/10.1074/jbc.M114.634923"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25561740"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25561740"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Leticia K Lerner, Sandro Holzer, Mairi L Kilkenny, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.2019104185"}], "href": "https://doi.org/10.15252/embj.2019104185"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32705708"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32705708"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Federica Calì, Sanjay Kumar Bharti, Roberta Di Perna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkv1112"}], "href": "https://doi.org/10.1093/nar/gkv1112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26503245"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26503245"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Giuseppe Cortone, Ge Zheng, Pasquale Pensieri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of the Warsaw breakage syndrome DNA helicase DDX11 with the replication fork-protection factor Timeless promotes sister chromatid cohesion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1007622"}], "href": "https://doi.org/10.1371/journal.pgen.1007622"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30303954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30303954"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Niyant Shah, Akira Inoue, Seung Woo Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Roles of ChlR1 DNA helicase in replication recovery from DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2013.06.005"}], "href": "https://doi.org/10.1016/j.yexcr.2013.06.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23797032"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23797032"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "José-Mario Capo-Chichi, Sanjay Kumar Bharti, Joshua A Sommers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and biochemical characterization of a novel mutation in DDX11 causing Warsaw breakage syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.22226"}], "href": "https://doi.org/10.1002/humu.22226"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23033317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23033317"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Janne J M van Schie, Atiq Faramarz, Jesper A Balk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-18066-8"}], "href": "https://doi.org/10.1038/s41467-020-18066-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32855419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32855419"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Takuya Abe, Masato Ooka, Ryotaro Kawasumi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1803110115"}], "href": "https://doi.org/10.1073/pnas.1803110115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30061412"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30061412"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Sarah Eppley, Robert J Hopkin, Bryce Mendelsohn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical Report: Warsaw Breakage Syndrome with small radii and fibulae."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.38382"}], "href": "https://doi.org/10.1002/ajmg.a.38382"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28960803"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28960803"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Francesco P Marchese, Elena Grossi, Oskar Marín-Béjar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Long Noncoding RNA Regulates Sister Chromatid Cohesion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2016.06.031"}], "href": "https://doi.org/10.1016/j.molcel.2016.06.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27477908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27477908"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Chitralekha Bhattacharya, Xiaolei Wang, Dorothea Becker "}, {"type": "b", "children": [{"type": "t", "text": "The DEAD/DEAH box helicase, DDX11, is essential for the survival of advanced melanomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-11-82"}], "href": "https://doi.org/10.1186/1476-4598-11-82"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23116066"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23116066"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yan Yu, Dan Zhao, Kongfei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "E2F1 mediated DDX11 transcriptional activation promotes hepatocellular carcinoma progression through PI3K/AKT/mTOR pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-2478-0"}], "href": "https://doi.org/10.1038/s41419-020-2478-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32332880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32332880"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Zheng Ren, Xiaochun Liu, Yaoran Si, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA DDX11-AS1 facilitates gastric cancer progression by regulating miR-873-5p/SPC18 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Artif Cells Nanomed Biotechnol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21691401.2020.1726937"}], "href": "https://doi.org/10.1080/21691401.2020.1726937"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32054332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32054332"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "J-B Tian, L Cao, G-L Dong "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA DDX11-AS1 induced by YY1 accelerates colorectal cancer progression through targeting miR-873/CLDN7 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201907_18309"}], "href": "https://doi.org/10.26355/eurrev_201907_18309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31298324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31298324"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "W Song, Y Qian, M-H Zhang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "LncRNA DDX11 antisense RNA 1 promotes EMT process of esophageal squamous cell carcinoma by sponging miR-30d-5p to regulate SNAI1/ZEB2 expression and Wnt/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2008759"}], "href": "https://doi.org/10.1080/21655979.2021.2008759"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34866524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34866524"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "B Pérez-Benavente, J L García, M S Rodríguez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GSK3-SCF(FBXW7) targets JunB for degradation in G2 to preserve chromatid cohesion before anaphase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.235"}], "href": "https://doi.org/10.1038/onc.2012.235"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22710716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22710716"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Xinliang Sun, Hongbo Chen, Zaian Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Warsaw breakage syndrome-related protein DDX11 is required for ribosomal RNA synthesis and embryonic development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddv213"}], "href": "https://doi.org/10.1093/hmg/ddv213"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26089203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26089203"}]}]}]}
Synonyms	CHLR1, CHL1, KRG2, WABS
Proteins	DDX11_HUMAN
NCBI Gene ID	1663
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DDX11 has 7,167 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 119 datasets.

Click the + buttons to view associations for DDX11 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DDX11 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DDX11 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DDX11 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DDX11 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DDX11 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DDX11 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DDX11 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DDX11 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DDX11 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of DDX11 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DDX11 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DDX11 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with DDX11 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DDX11 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DDX11 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DDX11 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DDX11 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with DDX11 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with DDX11 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing DDX11 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DDX11 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DDX11 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing DDX11 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DDX11 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DDX11 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DDX11 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DDX11 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with DDX11 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with DDX11 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of DDX11 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving DDX11 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DDX11 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DDX11 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DDX11 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with DDX11 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DDX11 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DDX11 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DDX11 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing DDX11 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of DDX11 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with DDX11 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.