DDX51 Gene

HGNC Family	DEAD box polypeptides (DDX)
Name	DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
Description	Enables RNA binding activity. Predicted to be involved in chromatin looping; chromatin remodeling; and rRNA processing. Located in membrane. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DDX51 is a member of the DEAD‐box RNA helicase family with multifaceted roles in ribosome biogenesis and cellular proliferation. In higher eukaryotes, DDX51 is essential for the maturation of the large ribosomal subunit by facilitating formation of the 3′ end of 28S rRNA through displacement of U8 snoRNA from pre‐60S complexes, a critical step for productive pre‐rRNA processing."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, DDX51 has emerged as an important regulator of cell cycle progression; its depletion via siRNA leads to S‐phase arrest and reduced proliferation in non‐small cell lung cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similar inhibitory effects on cell growth have been observed in esophageal squamous cell carcinoma, where high DDX51 expression correlates with poor prognosis and its knockdown inactivates the PI3K/AKT signaling pathway"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", as well as in breast cancer, where reduction of DDX51 levels suppresses proliferation through modulation of the Wnt/β‐catenin pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, the methylation status of the DDX51 promoter has been shown to discriminate between subtypes in acute lymphoblastic leukemia, suggesting its potential as a biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Beyond its roles in ribosome assembly and tumorigenesis, DDX51 has also been identified among host factors implicated in SARS‐CoV‑2 replication"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "and is significantly mutated in malignant pleural mesothelioma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In proteomic analyses of fish liver, DDX51 has been linked to cell adhesion and RNA transport functions, highlighting its potential relevance in organogenesis and stress adaptation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Collectively, these studies underscore the central role of DDX51 in ribosome maturation and cell proliferation, and they point to its promise as a therapeutic target and biomarker in various human diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Leena Srivastava, Yevgeniya R Lapik, Minshi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00226-10"}], "href": "https://doi.org/10.1128/MCB.00226-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20404093"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20404093"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaojing Wang, Hongli Liu, Chengling Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The DEAD-box RNA helicase 51 controls non-small cell lung cancer proliferation by regulating cell cycle progression via multiple pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep26108"}], "href": "https://doi.org/10.1038/srep26108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27198888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27198888"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Dong-Xin Hu, Qi-Feng Sun, Lin Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of DEAD-box 51 inhibits tumor growth of esophageal squamous cell carcinoma "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " the PI3K/AKT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v28.i4.464"}], "href": "https://doi.org/10.3748/wjg.v28.i4.464"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35125830"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35125830"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Weibo Sun, Shundong Cang, Xiaodong Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DDX51 gene promotes proliferation by activating Wnt/β-catenin signaling in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2017)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31966432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31966432"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kristen H Taylor, Keila E Pena-Hernandez, J Wade Davis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Large-scale CpG methylation analysis identifies novel candidate genes and reveals methylation hotspots in acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-06-3993"}], "href": "https://doi.org/10.1158/0008-5472.CAN-06-3993"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17363581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17363581"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sneh Lata, Ritu Mishra, Ravi P Arya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Where all the Roads Meet? A Crossover Perspective on Host Factors Regulating SARS-CoV-2 infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2021.167403"}], "href": "https://doi.org/10.1016/j.jmb.2021.167403"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34914966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34914966"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Raphael Bueno, Eric W Stawiski, Leonard D Goldstein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.3520"}], "href": "https://doi.org/10.1038/ng.3520"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26928227"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26928227"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Guoqiang Zhang, Zhenbo Mou, Wenhua Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylated protein modification analysis on normal liver and Exo-celiac liver of Glyptosternum maculatum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Fish Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jfb.14877"}], "href": "https://doi.org/10.1111/jfb.14877"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34392541"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34392541"}]}]}]}
Proteins	DDX51_HUMAN
NCBI Gene ID	317781
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DDX51 has 5,592 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 108 datasets.

Click the + buttons to view associations for DDX51 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DDX51 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by DDX51 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DDX51 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DDX51 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DDX51 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DDX51 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DDX51 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DDX51 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DDX51 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DDX51 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DDX51 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DDX51 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DDX51 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with DDX51 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DDX51 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DDX51 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DDX51 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DDX51 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing DDX51 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DDX51 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DDX51 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing DDX51 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing DDX51 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DDX51 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DDX51 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DDX51 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DDX51 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with DDX51 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with DDX51 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DDX51 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DDX51 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DDX51 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DDX51 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DDX51 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DDX51 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing DDX51 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of DDX51 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing DDX51 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of DDX51 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of DDX51 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of DDX51 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.