{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe DEK protein is a multifaceted nuclear factor that plays a central role in the organization and regulation of chromatin structure. It functions as an architectural protein that binds DNA in a sequence‐nonspecific manner, modulating DNA topology, nucleosome organization, and the balance between euchromatin and heterochromatin. In addition, DEK is intimately involved in transcriptional regulation, interacting with transcription factors and chromatin‐associated partners (including histone deacetylases, HP1α and histones) to either activate or repress gene expression. Its activity is regulated by post‐translational modifications and subdomain multifunctionality, which together enable DEK to serve as a histone chaperone and influence higher order chromatin dynamics."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond serving as a scaffold for chromatin organization, DEK exerts important regulatory effects on RNA processing and DNA repair. It has been shown to enforce proper 3′ splice site selection by interacting with key splicing factors, thereby safeguarding pre-mRNA maturation. In parallel, DEK participates in the cellular response to DNA damage—its modulation (including noncovalent interactions with poly(ADP‐ribose)) and influence on histone acetylation and nucleoprotein complex formation help control double strand break repair and non-homologous end joining. These roles underscore DEK’s capacity to maintain genomic stability under stress."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA wealth of evidence now implicates DEK as a potent oncogenic factor that supports cellular proliferation, inhibits senescence, and disrupts normal differentiation processes. Overexpression of DEK has been observed in multiple tumor types—including retinoblastoma, melanoma, cervical, breast, ovarian, gastric cancers, and leukemias—with DEK upregulation often correlating with chemoresistance and an aggressive clinical course. In certain contexts, DEK is transcriptionally induced by oncogenic viral proteins such as HPV E7, and chromosomal translocations involving DEK (e.g. DEK-NUP214) further reinforce its direct involvement in malignant transformation. Collectively, these alterations in DEK expression and function promote tumor initiation, progression, and metastatic spread."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "32"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its nuclear functions, DEK can be secreted and act in a paracrine fashion to modulate inflammation and hematopoietic responses. Extracellular DEK acts as a chemoattractant for immune cells and has been detected in synovial fluids from arthritis patients, where it may contribute to sustained inflammatory responses. Moreover, DEK influences stem and progenitor cell proliferation and differentiation, suggesting a role in hematopoietic homeostasis. These attributes, together with emerging targeted approaches (such as DEK-neutralizing aptamers), highlight the translational potential of therapeutically modulating DEK activity in both cancer and chronic inflammatory diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "33", "end_ref": "37"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marcelo L Larramendy, Tarja Niini, Erkki Elonen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2002)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12031912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12031912"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Andrew D Hollenbach, Craig J McPherson, Edwin J Mientjes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.115.16.3319"}], "href": "https://doi.org/10.1242/jcs.115.16.3319"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12140263"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12140263"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Anita Krithivas, Masahiro Fujimuro, Magdalena Weidner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/jvi.76.22.11596-11604.2002"}], "href": "https://doi.org/10.1128/jvi.76.22.11596-11604.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12388720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12388720"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kajal V Sitwala, Kristine Adams, David M Markovitz "}, {"type": "b", "children": [{"type": "t", "text": "YY1 and NF-Y binding sites regulate the transcriptional activity of the dek and dek-can promoter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1206041"}], "href": "https://doi.org/10.1038/sj.onc.1206041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12483538"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12483538"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ferdinand Kappes, Ingo Scholten, Nicole Richter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional domains of the ubiquitous chromatin protein DEK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.24.13.6000-6010.2004"}], "href": "https://doi.org/10.1128/MCB.24.13.6000-6010.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15199153"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15199153"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Tanja Waldmann, Ingo Scholten, Ferdinand Kappes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2004.08.029"}], "href": "https://doi.org/10.1016/j.gene.2004.08.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15563827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15563827"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Friederike Böhm, Ferdinand Kappes, Ingo Scholten, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The SAF-box domain of chromatin protein DEK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gki258"}], "href": "https://doi.org/10.1093/nar/gki258"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15722484"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15722484"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Corinna Grasemann, Sandrine Gratias, Harald Stephan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1208792"}], "href": "https://doi.org/10.1038/sj.onc.1208792"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16007192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16007192"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Maria Stella Carro, Fabio Mario Spiga, Micaela Quarto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DEK Expression is controlled by E2F and deregulated in diverse tumor types."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.5.11.2801"}], "href": "https://doi.org/10.4161/cc.5.11.2801"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16721057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16721057"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Morgan Sammons, Shan Shan Wan, Nancy L Vogel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Negative regulation of the RelA/p65 transactivation function by the product of the DEK proto-oncogene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M600915200"}], "href": "https://doi.org/10.1074/jbc.M600915200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16829531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16829531"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Erica Riveiro-Falkenbach, María S Soengas "}, {"type": "b", "children": [{"type": "t", "text": "Control of tumorigenesis and chemoresistance by the DEK oncogene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-09-2330"}], "href": "https://doi.org/10.1158/1078-0432.CCR-09-2330"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20501624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20501624"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ferdinand Kappes, Tanja Waldmann, Veena Mathew, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.2036411"}], "href": "https://doi.org/10.1101/gad.2036411"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21460035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21460035"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Carl Sandén, Linnea Järvstråt, Andreas Lennartsson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The DEK oncoprotein binds to highly and ubiquitously expressed genes with a dual role in their transcriptional regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-13-215"}], "href": "https://doi.org/10.1186/1476-4598-13-215"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25216995"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25216995"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Trisha M Wise-Draper, Hillary V Allen, Megan N Thobe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The human DEK proto-oncogene is a senescence inhibitor and an upregulated target of high-risk human papillomavirus E7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.79.22.14309-14317.2005"}], "href": "https://doi.org/10.1128/JVI.79.22.14309-14317.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16254365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16254365"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Soo-Il Ko, In-Seon Lee, Ji-Young Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of histone acetyltransferase activity of p300 and PCAF by proto-oncogene protein DEK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2006.04.081"}], "href": "https://doi.org/10.1016/j.febslet.2006.04.081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16696975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16696975"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Luis Miguel Mendes Soares, Katia Zanier, Cameron Mackereth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intron removal requires proofreading of U2AF/3' splice site recognition by DEK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1128659"}], "href": "https://doi.org/10.1126/science.1128659"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16809543"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16809543"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "F Kappes, J Fahrer, M S Khodadoust, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01921-07"}], "href": "https://doi.org/10.1128/MCB.01921-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18332104"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18332104"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jörg Fahrer, Oliver Popp, Maria Malanga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High-affinity interaction of poly(ADP-ribose) and the human DEK oncoprotein depends upon chain length."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi1004365"}], "href": "https://doi.org/10.1021/bi1004365"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20669926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20669926"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Gina M Kavanaugh, Trisha M Wise-Draper, Richard J Morreale, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The human DEK oncogene regulates DNA damage response signaling and repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkr454"}], "href": "https://doi.org/10.1093/nar/gkr454"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21653549"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21653549"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Ferdinand Kappes, Catalina Damoc, Rolf Knippers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.24.13.6011-6020.2004"}], "href": "https://doi.org/10.1128/MCB.24.13.6011-6020.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15199154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15199154"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Marija Orlic, Clarellen E Spencer, Lisa Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression analysis of 6p22 genomic gain in retinoblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.20263"}], "href": "https://doi.org/10.1002/gcc.20263"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16180235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16180235"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Mohamed Mokhtar Desouki, Mariola Kulawiec, Sanjay Bansal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cross talk between mitochondria and superoxide generating NADPH oxidase in breast and ovarian tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cbt.4.12.2233"}], "href": "https://doi.org/10.4161/cbt.4.12.2233"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16294028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16294028"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Trisha M Wise-Draper, Hillary V Allen, Elizabeth E Jones, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Apoptosis inhibition by the human DEK oncoprotein involves interference with p53 functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00430-06"}], "href": "https://doi.org/10.1128/MCB.00430-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16894028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16894028"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Qunying Wu, Zhuhu Li, Hai Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DEK overexpression in uterine cervical cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Int (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1440-1827.2008.02239.x"}], "href": "https://doi.org/10.1111/j.1440-1827.2008.02239.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18477217"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18477217"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Trisha M Wise-Draper, Richard J Morreale, Teresa A Morris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DEK proto-oncogene expression interferes with the normal epithelial differentiation program."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2009.080330"}], "href": "https://doi.org/10.2353/ajpath.2009.080330"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19036808"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19036808"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Trisha M Wise-Draper, Rachael A Mintz-Cole, Teresa A Morris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-2304"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-2304"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19223548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19223548"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Songying Han, Yanhua Xuan, Shuangping Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinicopathological significance of DEK overexpression in serous ovarian tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Int (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1440-1827.2009.02392.x"}], "href": "https://doi.org/10.1111/j.1440-1827.2009.02392.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19563407"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19563407"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "L M Privette Vinnedge, R McClaine, P K Wagh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The human DEK oncogene stimulates β-catenin signaling, invasion and mammosphere formation in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.2"}], "href": "https://doi.org/10.1038/onc.2011.2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21317931"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21317931"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Lisa M Privette Vinnedge, Shuk-Mei Ho, Kathryn A Wikenheiser-Brokamp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0046985"}], "href": "https://doi.org/10.1371/journal.pone.0046985"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23071688"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23071688"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Carl Sandén, Malin Ageberg, Jessica Petersson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Forced expression of the DEK-NUP214 fusion protein promotes proliferation dependent on upregulation of mTOR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-13-440"}], "href": "https://doi.org/10.1186/1471-2407-13-440"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24073922"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24073922"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Julie Damgaard Sandahl, Eva A Coenen, Erik Forestier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "t(6;9)(p22;q34)/DEK-NUP214-rearranged pediatric myeloid leukemia: an international study of 62 patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3324/haematol.2013.098517"}], "href": "https://doi.org/10.3324/haematol.2013.098517"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24441146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24441146"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Junjie Piao, Yongjun Shang, Shuangping Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High expression of DEK predicts poor prognosis of gastric adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diagn Pathol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1746-1596-9-67"}], "href": "https://doi.org/10.1186/1746-1596-9-67"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24650035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24650035"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Nirit Mor-Vaknin, Antonello Punturieri, Kajal Sitwala, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The DEK nuclear autoantigen is a secreted chemotactic factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01030-06"}], "href": "https://doi.org/10.1128/MCB.01030-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17030615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17030615"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Nirit Mor-Vaknin, Ferdinand Kappes, Amalie E Dick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DEK in the synovium of patients with juvenile idiopathic arthritis: characterization of DEK antibodies and posttranslational modification of the DEK autoantigen."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheum (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.30138"}], "href": "https://doi.org/10.1002/art.30138"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21280010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21280010"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Hal E Broxmeyer, Ferdinand Kappes, Nirit Mor-Vaknin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DEK regulates hematopoietic stem engraftment and progenitor cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells Dev (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/scd.2011.0451"}], "href": "https://doi.org/10.1089/scd.2011.0451"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21943234"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21943234"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Rositsa I Koleva, Scott B Ficarro, Hanna S Radomska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C/EBPα and DEK coordinately regulate myeloid differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-10-383083"}], "href": "https://doi.org/10.1182/blood-2011-10-383083"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22474248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22474248"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Nirit Mor-Vaknin, Anjan Saha, Maureen Legendre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms14252"}], "href": "https://doi.org/10.1038/ncomms14252"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28165452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28165452"}]}]}]}