{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA DGCR5 has emerged as a multifunctional regulator with highly context‐dependent roles in human diseases. In various cancers, DGCR5 can function either as a tumor suppressor or as an oncogene. For example, in lung adenocarcinoma, hepatocellular carcinoma, gastric cancer, non‐small cell lung cancer, glioma, and cervical cancer, reduced DGCR5 expression is associated with enhanced tumor cell proliferation, migration, invasion, and poor clinical outcome – largely through its ability to “sponge” microRNAs such as miR‑22‑3p, miR‑346, miR‑23b, miR‑211‑5p, miR‑1180, and others, which in turn deregulate key targets (e.g. BCL‑2/BAX, KLF14, PTEN, BTG1, AKT/GSK‑3β/β‑catenin) and signaling pathways including Wnt/β‑catenin (1,2,3,4,6,7,15). In contrast, in malignancies such as esophageal squamous cell carcinoma, pancreatic cancer, triple‐negative breast cancer, and clear cell renal cell carcinoma, DGCR5 is upregulated and appears to promote oncogenic properties by modulating alternative splicing regulators (e.g. SRSF1), sustaining cancer stem cell traits, or enhancing metastasis via ceRNA mechanisms (5,8,16). Beyond cancer, DGCR5 has been implicated in non‐neoplastic conditions. For instance, its downregulation in bone marrow mesenchymal stem cells attenuates osteogenic differentiation in postmenopausal osteoporosis, whereas in neurological contexts DGCR5 participates in neural development and injury responses by modulating apoptotic pathways (10,13,17). Moreover, DGCR5 expression is modulated by transcriptional repressors such as REST in neural cells, linking it to broader neurodegenerative processes (14). Collectively, these findings indicate that DGCR5 exerts its biological effects by acting as a competing endogenous RNA or molecular scaffold that fine‑tunes key regulatory networks—further underscoring its potential as a prognostic indicator and therapeutic target in a spectrum of diseases (1,2,3,4,5,6,7,8,10,13,14,15,16,17).\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n "}, {"type": "b", "children": [{"type": "t", "text": "Citations:"}]}, {"type": "t", "text": "<br>\n (1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ",&nbsp;\n (2)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ",&nbsp;\n (3)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ",&nbsp;\n (4)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ",&nbsp;\n (5)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ",&nbsp;\n (6)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ",&nbsp;\n (7)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ",&nbsp;\n (8)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ",&nbsp;\n (10)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ",&nbsp;\n (13)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ",&nbsp;\n (14)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ",&nbsp;\n (15)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ",&nbsp;\n (16)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ",&nbsp;\n (17)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hui-Xing Dong, Ren Wang, Xiao-Yan Jin, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA DGCR5 suppresses gastric cancer progression by acting as a competing endogenous RNA of PTEN and BTG1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.27861"}], "href": "https://doi.org/10.1002/jcp.27861"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30515803"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30515803"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Shi-Lei Liu, Chen Cai, Zi-Yi Yang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "DGCR5 induces osteogenic differentiation by up-regulating Runx2 through miR-30d-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.09.033"}], "href": "https://doi.org/10.1016/j.bbrc.2018.09.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30266402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30266402"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Chengwei Peng, Chuanqing Zhang, Zhe Su, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Regulation of neural macroRNAs by the transcriptional repressor REST."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1261/rna.1127009"}], "href": "https://doi.org/10.1261/rna.1127009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19050060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19050060"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "En-Guo Chen, Ji-Song Zhang, Shan Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA DGCR5 is involved in the regulation of proliferation, migration and invasion of lung cancer by targeting miR-1180."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Cancer Res (2017)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28744397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28744397"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Guang-Xin Zhong, Dan Luo, Yi-Jun Fan, et al. 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