DIP2C Gene

Name	DIP2 disco-interacting protein 2 homolog C (Drosophila)
Description	This gene encodes a member of the disco-interacting protein homolog 2 family. The protein shares strong similarity with a Drosophila protein which interacts with the transcription factor disco and is expressed in the nervous system. [provided by RefSeq, Oct 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DIP2C is emerging as a multifunctional regulator implicated in diverse biological processes spanning cancer, neurodevelopment, and cardiovascular biology. In several human cancers, including breast cancer, recurrent somatic mutations in DIP2C and its decreased expression—particularly in basal‐like and HER2 subtypes—suggest a potential tumor‐suppressive role, with loss of DIP2C function leading to widespread changes in DNA methylation, gene expression, epithelial–mesenchymal transition, and cellular senescence."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " Moreover, DIP2C has been identified as a recurrent 3′ fusion partner of MAP3K8 in a subset of skin tumors, suggesting that gene fusions involving DIP2C may contribute to aberrant activation of oncogenic signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " A genome‐wide association study also linked a DIP2C single‐nucleotide polymorphism with plasma uric acid levels, indicating a role in metabolic regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In the cardiovascular arena, a circular RNA generated from DIP2C (circDIP2C) has been shown to protect endothelial cells from oxidized low‐density lipoprotein–induced injury by sequestering microRNA‑556‑5p and thereby upregulating TET2 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Neurodevelopmental involvement is further supported by the discovery of a de novo splicing variant in DIP2C associated with focal infantile epilepsy"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", while its differential expression in osmoregulatory tissues of tilapia under salinity stress suggests an evolutionarily conserved role in environmental responsiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Finally, DIP2C lies within a chromosomal region frequently affected by microdeletions that correlate with developmental delay and neuropsychiatric features, and ongoing CRISPR‐based transcriptomic studies in murine models are beginning to illuminate its regulatory functions in the brain."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiang Jiao, Laura D Wood, Monica Lindman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Somatic mutations in the Notch, NF-KB, PIK3CA, and Hedgehog pathways in human breast cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.21935"}], "href": "https://doi.org/10.1002/gcc.21935"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22302350"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22302350"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chatarina Larsson, Muhammad Akhtar Ali, Tatjana Pandzic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of DIP2C in RKO cells stimulates changes in DNA methylation and epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-017-3472-5"}], "href": "https://doi.org/10.1186/s12885-017-3472-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28716088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28716088"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jing Li, Jin Liang Ping, Bo Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DIP2C expression in breast cancer and its clinical significance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2017.09.007"}], "href": "https://doi.org/10.1016/j.prp.2017.09.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28964575"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28964575"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Aurelie Houlier, Daniel Pissaloux, Ingrid Masse, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Melanocytic tumors with MAP3K8 fusions: report of 33 cases with morphological-genetic correlations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Pathol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41379-019-0384-8"}], "href": "https://doi.org/10.1038/s41379-019-0384-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31719662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31719662"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Wei-Dong Li, Hongxiao Jiao, Kai Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Obesity (Silver Spring) (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/oby.20303"}], "href": "https://doi.org/10.1002/oby.20303"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23703922"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23703922"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Fudong Hu, Xi Chen, Juan Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircDIP2C ameliorates oxidized low-density lipoprotein-induced cell dysfunction by binding to miR-556-5p to induce TET2 in human umbilical vein endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Vascul Pharmacol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.vph.2021.106887"}], "href": "https://doi.org/10.1016/j.vph.2021.106887"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34147657"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34147657"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Le Yang, Siyu Zhao, Nan Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel DIP2C gene splicing variant in an individual with focal infantile epilepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.62524"}], "href": "https://doi.org/10.1002/ajmg.a.62524"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34617658"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34617658"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xiao Hui Gu, Dan Li Jiang, Yan Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identifying a Major QTL Associated with Salinity Tolerance in Nile Tilapia Using QTL-Seq."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mar Biotechnol (NY) (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10126-017-9790-4"}], "href": "https://doi.org/10.1007/s10126-017-9790-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29318417"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29318417"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Minh-Tuan Huynh, Cong Toai Tran, Madeleine Joubert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intragenic Deletion of the ZMYND11 Gene in 10p15.3 is Associated with Developmental Delay Phenotype: A Case Report."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytogenet Genome Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000518689"}], "href": "https://doi.org/10.1159/000518689"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34818214"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34818214"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Zin Mar Oo, Salah Adlat, Rajiv Kumar Sah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brain transcriptome study through CRISPR/Cas9 mediated mouse Dip2c gene knock-out."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2020.144975"}], "href": "https://doi.org/10.1016/j.gene.2020.144975"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32707302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32707302"}]}]}]}
Synonyms	KIAA0934
Proteins	DIP2C_HUMAN
NCBI Gene ID	22982
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DIP2C has 6,327 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 104 datasets.

Click the + buttons to view associations for DIP2C from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DIP2C Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DIP2C gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DIP2C gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DIP2C gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DIP2C gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DIP2C gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DIP2C gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DIP2C gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DIP2C gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DIP2C gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DIP2C gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DIP2C gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with DIP2C gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with DIP2C protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DIP2C gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DIP2C gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DIP2C gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DIP2C gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with DIP2C gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DIP2C gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DIP2C protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DIP2C protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DIP2C gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DIP2C gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with DIP2C gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with DIP2C gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with DIP2C gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of DIP2C protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by DIP2C gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with DIP2C gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with DIP2C gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DIP2C gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DIP2C gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DIP2C gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with DIP2C gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DIP2C gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DIP2C gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DIP2C gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing DIP2C from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with DIP2C gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of DIP2C gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.