| Name | disrupted in renal carcinoma 3 |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe long non-coding RNA DIRC3 has been identified as a tumor suppressor in melanoma, where it is integrated within the MITF–SOX10 transcriptional network. In melanoma cells, nuclear DIRC3 promotes a less malignant phenotype by modulating chromatin structure to activate the transcription of the neighboring tumor suppressor IGFBP5, thereby reducing SOX10 occupancy at regulatory elements. Loss of DIRC3 expression leads to enhanced anchorage-independent growth—a hallmark of malignant transformation—and is associated with decreased patient survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Disrupted In Renal Carcinoma 3 also emerges as a clinically relevant locus in head and neck cancers. In laryngeal squamous cell carcinoma, a specific single nucleotide polymorphism within DIRC3 (rs966423) correlates with significantly poorer survival outcomes, underscoring its potential utility as a prognostic marker and its broader role in cancer biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "In differentiated thyroid cancers, DIRC3 is downregulated relative to normal tissue, and its diminished expression promotes a more aggressive cancer phenotype—characterized by increased migration and invasiveness along with reduced apoptosis. Mechanistically, reduced DIRC3 impedes the upregulation of IGFBP5, thereby enhancing IGF1-induced Akt signaling and contributing to thyroid carcinogenesis. These findings reinforce the role of DIRC3 as a critical modulator of the IGFBP5/IGF1/Akt axis in tumor suppression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Elizabeth A Coe, Jennifer Y Tan, Michael Shapiro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The MITF-SOX10 regulated long non-coding RNA DIRC3 is a melanoma tumour suppressor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1008501"}], "href": "https://doi.org/10.1371/journal.pgen.1008501"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31881017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31881017"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhen Shen, Wanli Ren, Yanxia Bai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DIRC3 and near NABP1 genetic polymorphisms are associated laryngeal squamous cell carcinoma patient survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.12865"}], "href": "https://doi.org/10.18632/oncotarget.12865"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27793000"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27793000"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Piotr T Wysocki, Karol Czubak, Anna A Marusiak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA DIRC3 regulates invasiveness and insulin-like growth factor signaling in thyroid cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocr Relat Cancer (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/ERC-23-0058"}], "href": "https://doi.org/10.1530/ERC-23-0058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37130273"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37130273"}]}]}]}
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| NCBI Gene ID | 729582 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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DIRC3 has 1,536 functional associations with biological entities spanning 5 categories (molecular profile, chemical, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 35 datasets.
Click the + buttons to view associations for DIRC3 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of DIRC3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of DIRC3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of DIRC3 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of DIRC3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with DIRC3 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| dbGAP Gene-Trait Associations | traits associated with DIRC3 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores | diseases associated with DIRC3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with DIRC3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at DIRC3 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of DIRC3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of DIRC3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of DIRC3 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of DIRC3 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of DIRC3 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of DIRC3 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of DIRC3 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of DIRC3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of DIRC3 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GWAS Catalog SNP-Phenotype Associations | phenotypes associated with DIRC3 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with DIRC3 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with DIRC3 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of DIRC3 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of DIRC3 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of DIRC3 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with DIRC3 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with DIRC3 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of DIRC3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of DIRC3 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of DIRC3 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of DIRC3 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of DIRC3 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at DIRC3 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of DIRC3 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of DIRC3 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with DIRC3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
