DMTF1 Gene

HGNC Family	SANT/Myb domain containing
Name	cyclin D binding myb-like transcription factor 1
Description	This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DMTF1 (also known as Dmp1) is a Myb‐like transcription factor that plays a pivotal role in tumor suppression predominantly through activation of the ARF–p53 pathway. Activation of DMTF1 by oncogenic signals such as Ras–Raf and HER2/neu stimulates the transcription of ARF, leading to p53‐mediated cell‐cycle arrest and apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, DMTF1 can directly interact with p53 and antagonize its polyubiquitination by Mdm2, thereby stabilizing p53 and reinforcing its tumor‐suppressive functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Alternative splicing of the DMTF1 gene generates multiple isoforms. The full‐length DMTF1α isoform functions as a transcriptional activator of ARF, whereas the DMTF1β (and possibly DMTF1γ) isoforms lack this ability and actively antagonize DMTF1α’s activity, thereby exerting oncogenic effects independent of p53 activation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": " Moreover, loss of heterozygosity at the DMTF1 locus or its downregulation by microRNAs (such as miR-155 in bladder cancer and miR-675-3p in colorectal cancer) further compromises its tumor-suppressive action and contributes to accelerated cell proliferation and tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In various tumor types including lung, breast, bladder, and colorectal cancers—and even in the regulation of hematopoietic stem cell proliferation—the balance between the tumor-suppressive DMTF1α and the oncogenic splice variants is critical. Shifts in this balance, through genetic alteration or post-transcriptional regulation, disrupt the normal ARF–p53 axis and underlie more aggressive disease phenotypes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that DMTF1 functions as a context-dependent regulator of cell proliferation and tumorigenesis. Its tumor-suppressive activity is mediated by the activation of the ARF–p53 axis and direct stabilization of p53, while the generation of oncogenic splice variants and microRNA-mediated suppression contribute to cancer progression by disrupting this critical regulatory network.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ali Mallakin, Takayuki Sugiyama, Pankaj Taneja, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2007.08.034"}], "href": "https://doi.org/10.1016/j.ccr.2007.08.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17936562"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17936562"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Pankaj Taneja, Dejan Maglic, Fumitake Kai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical roles of DMP1 in human epidermal growth factor receptor 2/neu-Arf-p53 signaling and breast cancer development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-10-0159"}], "href": "https://doi.org/10.1158/0008-5472.CAN-10-0159"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21062982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21062982"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Donna P Frazier, Robert D Kendig, Fumitake Kai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dmp1 physically interacts with p53 and positively regulates p53's stability, nuclear localization, and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-11-2410"}], "href": "https://doi.org/10.1158/0008-5472.CAN-11-2410"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22331460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22331460"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mario P Tschan, Kimberlee M Fischer, Vivian S Fung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alternative splicing of the human cyclin D-binding Myb-like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M307067200"}], "href": "https://doi.org/10.1074/jbc.M307067200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12917399"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12917399"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kazushi Inoue, Elizabeth A Fry "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant splicing of the DMP1-ARF-MDM2-p53 pathway in cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.30003"}], "href": "https://doi.org/10.1002/ijc.30003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26802432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26802432"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Na Tian, Jialiang Li, Jinming Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "From General Aberrant Alternative Splicing in Cancers and Its Therapeutic Application to the Discovery of an Oncogenic DMTF1 Isoform."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms18030191"}], "href": "https://doi.org/10.3390/ijms18030191"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28257090"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28257090"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yang Peng, Wen Dong, Tian-Xin Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-155 promotes bladder cancer growth by repressing the tumor suppressor DMTF1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.3755"}], "href": "https://doi.org/10.18632/oncotarget.3755"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25965824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25965824"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xueliang Yang, Yang Lou, Minghua Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR‑675 promotes colorectal cancer cell growth dependent on tumor suppressor DMTF1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9780"}], "href": "https://doi.org/10.3892/mmr.2018.9780"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30592263"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30592263"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ali Mallakin, Takayuki Sugiyama, Fumitake Kai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Arf-inducing transcription factor Dmp1 encodes a transcriptional activator of amphiregulin, thrombospondin-1, JunB and Egr1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.24938"}], "href": "https://doi.org/10.1002/ijc.24938"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19816943"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19816943"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Dejan Maglic, Daniel B Stovall, J Mark Cline, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DMP1β, a splice isoform of the tumour suppressor DMP1 locus, induces proliferation and progression of breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pathol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/path.4504"}], "href": "https://doi.org/10.1002/path.4504"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25537728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25537728"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "D Maglic, S Zhu, E A Fry, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic value of the hDMP1-ARF-Hdm2-p53 pathway in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.423"}], "href": "https://doi.org/10.1038/onc.2012.423"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23045280"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23045280"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Michihiro Kobayashi, Edward F Srour "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of murine hematopoietic stem cell quiescence by Dmtf1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-05-349084"}], "href": "https://doi.org/10.1182/blood-2011-05-349084"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22039255"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22039255"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Mario P Tschan, Elena A Federzoni, Aladin Haimovici, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human DMTF1β antagonizes DMTF1α regulation of the p14(ARF) tumor suppressor and promotes cellular proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagrm.2015.07.009"}], "href": "https://doi.org/10.1016/j.bbagrm.2015.07.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26187004"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26187004"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Elizabeth A Fry, Kazushi Inoue "}, {"type": "b", "children": [{"type": "t", "text": "c-MYB and DMTF1 in Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Invest (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/07357907.2018.1550090"}], "href": "https://doi.org/10.1080/07357907.2018.1550090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30599775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30599775"}]}]}]}
Synonyms	DMTF, DMP1, HDMP1, MRUL
Proteins	DMTF1_HUMAN
NCBI Gene ID	9988
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DMTF1 has 8,146 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 125 datasets.

Click the + buttons to view associations for DMTF1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DMTF1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by DMTF1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DMTF1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DMTF1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DMTF1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DMTF1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DMTF1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DMTF1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DMTF1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DMTF1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DMTF1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of DMTF1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DMTF1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DMTF1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DMTF1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DMTF1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DMTF1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DMTF1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with DMTF1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of DMTF1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DMTF1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DMTF1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing DMTF1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing DMTF1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing DMTF1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DMTF1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DMTF1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DMTF1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DMTF1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with DMTF1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with DMTF1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with DMTF1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of DMTF1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by DMTF1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with DMTF1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with DMTF1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DMTF1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DMTF1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DMTF1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with DMTF1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DMTF1 gene from the ENCODE Histone Modification Site Profiles dataset.