DNAJB6 Gene

HGNC Family	Heat shock proteins
Name	DnaJ (Hsp40) homolog, subfamily B, member 6
Description	This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DNAJB6, a member of the Hsp40 (DNAJ) co‐chaperone family, is emerging as a multifunctional protein that protects cells against toxic protein aggregation and modulates key signaling pathways in a range of diseases. It is expressed as at least two major isoforms with distinct subcellular localizations: a predominantly nuclear form (DNAJB6a) and a cytoplasmic variant (DNAJB6b). DNAJB6’s potent anti‐aggregation function is evidenced by its ability to directly interact with aggregation‐prone proteins—including polyglutamine‐ and amyloid‐β peptides—to prevent amyloid fibril formation, a property that is underpinned by its oligomeric structure and a conserved serine/threonine‐rich region essential for its activity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Mutations in the conserved glycine/phenylalanine (G/F) domain of DNAJB6 have been causally linked to limb‐girdle muscular dystrophy type 1D (LGMD1D), a disorder characterized by protein inclusions, rimmed vacuoles, and disruption of myofibrillar organization. In patient families and corresponding animal models, these dominant missense and splicing mutations compromise the chaperone’s normal function, leading to the aberrant accumulation of misfolded substrates such as TDP‐43, desmin, and keratins, as well as the misregulation of stress granule dynamics at the Z‐disc."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In parallel, DNAJB6 exerts tumor‐suppressive functions. Its nuclear isoform contributes to the inhibition of oncogenic signaling by up‐regulating inhibitors such as DKK1 and by suppressing Wnt/β‐catenin and AKT pathways—mechanisms that reduce cell invasion, migration, and metastatic potential in breast and esophageal cancers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its roles in maintaining proteostasis and tumor suppression, DNAJB6 also facilitates the nuclear import of regulatory proteins. Its interaction with proteins involved in cell cycle control and transcription—illustrated by its binding to factors such as Slfn1 in T‐cells—underscores a critical function in promoting cell‐cycle arrest and preserving cellular quiescence."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, DNAJB6 has been implicated in viral pathogenesis; by interacting with the HIV‐2 accessory protein Vpx, it enhances the nuclear import of the viral preintegration complex, thereby facilitating efficient infection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, studies employing both biochemical and cell‐based approaches, including those using chimeric constructs and alternative splicing analyses, have begun to reveal how DNAJB6’s conformational dynamics and client‐binding specificity underpin its diverse regulatory roles in proteostasis, muscle integrity, cell signaling, and pathogen interactions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings position DNAJB6 as a critical, multifaceted co‐chaperone that not only inhibits amyloid and aggregate formation but also fine‐tunes cellular signaling and protein trafficking—mechanisms that together have profound implications for neuromuscular, neurodegenerative, oncogenic, and infectious diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cecilia Månsson, Paolo Arosio, Rasha Hussein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.595124"}], "href": "https://doi.org/10.1074/jbc.M114.595124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25217638"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25217638"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Judith Gillis, Sabine Schipper-Krom, Katrin Juenemann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The DNAJB6 and DNAJB8 protein chaperones prevent intracellular aggregation of polyglutamine peptides."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.421685"}], "href": "https://doi.org/10.1074/jbc.M112.421685"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23612975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23612975"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Arun Thiruvalluvan, Eduardo P de Mattos, Jeanette F Brunsting, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2020.02.022"}], "href": "https://doi.org/10.1016/j.molcel.2020.02.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32268123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32268123"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Christopher A G Söderberg, Cecilia Månsson, Katja Bernfur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural modelling of the DNAJB6 oligomeric chaperone shows a peptide-binding cleft lined with conserved S/T-residues at the dimer interface."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-23035-9"}], "href": "https://doi.org/10.1038/s41598-018-23035-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29581438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29581438"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jaakko Sarparanta, Per Harald Jonson, Christelle Golzio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.1103"}], "href": "https://doi.org/10.1038/ng.1103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22366786"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22366786"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Matthew B Harms, R Brian Sommerville, Peggy Allred, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exome sequencing reveals DNAJB6 mutations in dominantly-inherited myopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Neurol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ana.22683"}], "href": "https://doi.org/10.1002/ana.22683"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22334415"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22334415"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Kevin C Stein, Rocio Bengoechea, Matthew B Harms, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myopathy-causing mutations in an HSP40 chaperone disrupt processing of specific client conformers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.572461"}], "href": "https://doi.org/10.1074/jbc.M114.572461"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24920671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24920671"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Takatoshi Sato, Yukiko K Hayashi, Yasushi Oya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNAJB6 myopathy in an Asian cohort and cytoplasmic/nuclear inclusions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuromuscul Disord (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nmd.2012.12.010"}], "href": "https://doi.org/10.1016/j.nmd.2012.12.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23394708"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23394708"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Alessandra Ruggieri, Francesco Brancati, Simona Zanotti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Complete loss of the DNAJB6 G/F domain and novel missense mutations cause distal-onset DNAJB6 myopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neuropathol Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40478-015-0224-0"}], "href": "https://doi.org/10.1186/s40478-015-0224-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26205529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26205529"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Rocio Bengoechea, Sara K Pittman, Elizabeth P Tuck, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myofibrillar disruption and RNA-binding protein aggregation in a mouse model of limb-girdle muscular dystrophy 1D."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddv363"}], "href": "https://doi.org/10.1093/hmg/ddv363"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26362252"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26362252"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jerry F Tien, Alborz Mazloomian, S-W Grace Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkx187"}], "href": "https://doi.org/10.1093/nar/gkx187"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28334900"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28334900"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Aparna Mitra, Mitchell E Menezes, Lalita A Shevde, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNAJB6 induces degradation of beta-catenin and causes partial reversal of mesenchymal phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.094847"}], "href": "https://doi.org/10.1074/jbc.M109.094847"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20522561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20522561"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Mitchell E Menezes, Aparna Mitra, Lalita A Shevde, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNAJB6 governs a novel regulatory loop determining Wnt/β-catenin signalling activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20120205"}], "href": "https://doi.org/10.1042/BJ20120205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22455953"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22455953"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Bin Jiang, YongQiang Zhao, Mo Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNAJB6 Promotes Ferroptosis in Esophageal Squamous Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-019-05929-4"}], "href": "https://doi.org/10.1007/s10620-019-05929-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31701262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31701262"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yan-Shan Dai, Jian Xu, Jeffery D Molkentin "}, {"type": "b", "children": [{"type": "t", "text": "The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.22.9936-9948.2005"}], "href": "https://doi.org/10.1128/MCB.25.22.9936-9948.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16260608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16260608"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yafeng Zhang, Zhengmin Yang, Yonghao Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Hsp40 family chaperone protein DnaJB6 enhances Schlafen1 nuclear localization which is critical for promotion of cell-cycle arrest in T-cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20071510"}], "href": "https://doi.org/10.1042/BJ20071510"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18373498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18373498"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Xiaogang Cheng, Michael Belshan, Lee Ratner "}, {"type": "b", "children": [{"type": "t", "text": "Hsp40 facilitates nuclear import of the human immunodeficiency virus type 2 Vpx-mediated preintegration complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00540-07"}], "href": "https://doi.org/10.1128/JVI.00540-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18032501"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18032501"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Valen Zhuoyou Yu, Victor Chun-Lam Wong, Wei Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear Localization of DNAJB6 Is Associated With Survival of Patients With Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2015.08.025"}], "href": "https://doi.org/10.1053/j.gastro.2015.08.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26302489"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26302489"}]}]}]}
Synonyms	HSJ-2, MRJ, LGMDD1, DnaJ, MSJ-1, HHDJ1, DJ4
Proteins	DNJB6_HUMAN
NCBI Gene ID	10049
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DNAJB6 has 9,363 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 128 datasets.

Click the + buttons to view associations for DNAJB6 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DNAJB6 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DNAJB6 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DNAJB6 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DNAJB6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DNAJB6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DNAJB6 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving DNAJB6 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DNAJB6 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DNAJB6 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DNAJB6 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of DNAJB6 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DNAJB6 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DNAJB6 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with DNAJB6 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DNAJB6 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DNAJB6 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DNAJB6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DNAJB6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with DNAJB6 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with DNAJB6 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing DNAJB6 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DNAJB6 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DNAJB6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing DNAJB6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing DNAJB6 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing DNAJB6 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DNAJB6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DNAJB6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DNAJB6 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DNAJB6 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with DNAJB6 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with DNAJB6 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of DNAJB6 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by DNAJB6 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving DNAJB6 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving DNAJB6 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DNAJB6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DNAJB6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DNAJB6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with DNAJB6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DNAJB6 gene from the ENCODE Histone Modification Site Profiles dataset.