DOCK5 Gene

Name	dedicator of cytokinesis 5
Description	This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DOCK5 is an atypical guanine nucleotide exchange factor that plays multifaceted roles in regulating cytoskeletal dynamics and cell adhesion in diverse cell types. In osteoclasts, DOCK5 is essential for proper podosome organization and the formation and stabilization of sealing zones, thereby facilitating bone resorption. Its activity in these cells is coordinated through interactions with adaptor proteins such as tensin‐3 and p130Cas, and it modulates microtubule dynamics through both Rac1‐dependent and –independent mechanisms to control the adhesive and resorptive functions of osteoclasts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " In addition, DOCK5 contributes to the regulation of actin-driven membrane dynamics in other cell types; for instance, it functions alongside DOCK1 to mediate peripheral ruffle formation during Rac1 activation in response to growth factors"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "and promotes lamellipodial protrusion and focal adhesion turnover that underlie epithelial cell motility and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Genetic studies have also identified variants within the DOCK5 locus that are associated with obesity, suggesting a role in metabolic regulation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", while selective inhibition of DOCK5 using a small‐molecule inhibitor has provided insights into its unique regulatory mechanisms and therapeutic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In the context of development, although DOCK1 is critical for embryonic myoblast fusion, DOCK5 has been shown to contribute to myofiber development, thereby underscoring its auxiliary function in muscle formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Moreover, alternative transcripts derived from the DOCK5 gene, such as circ‐DOCK5, have been implicated in tumor metastasis by modulating microRNA stability and downstream signaling pathways in esophageal squamous cell carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Finally, decreased expression or homozygous deletion of DOCK5 has been observed in osteosarcoma and primary central nervous system lymphoma, implicating its loss in tumorigenesis and underscoring its potential role in maintaining normal cellular function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Virginie Vives, Mélanie Laurin, Gaelle Cres, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbmr.282"}], "href": "https://doi.org/10.1002/jbmr.282"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21542010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21542010"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Heiani Touaitahuata, Anne Morel, Serge Urbach, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.184622"}], "href": "https://doi.org/10.1242/jcs.184622"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27505886"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27505886"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sudipto Mukherjee, George A Pantelopulos, Vincent A Voelz "}, {"type": "b", "children": [{"type": "t", "text": "Markov models of the apo-MDM2 lid region reveal diffuse yet two-state binding dynamics and receptor poses for computational docking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep31631"}], "href": "https://doi.org/10.1038/srep31631"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27538695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27538695"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sarah Guimbal, Anne Morel, David Guérit, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dock5 is a new regulator of microtubule dynamic instability in osteoclasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Cell (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/boc.201900014"}], "href": "https://doi.org/10.1111/boc.201900014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31461543"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31461543"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Fumiyuki Sanematsu, Akihiko Nishikimi, Mayuki Watanabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.410423"}], "href": "https://doi.org/10.1074/jbc.M112.410423"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23362269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23362269"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "S R Frank, C P Köllmann, J F van Lidth de Jeude, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2016.345"}], "href": "https://doi.org/10.1038/onc.2016.345"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27669437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27669437"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Julia S El-Sayed Moustafa, Hariklia Eleftherohorinou, Adam J de Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/dds187"}], "href": "https://doi.org/10.1093/hmg/dds187"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22595969"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22595969"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yann Ferrandez, Wenhua Zhang, François Peurois, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-13619-2"}], "href": "https://doi.org/10.1038/s41598-017-13619-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29089502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29089502"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Mélanie Laurin, Nadine Fradet, Anne Blangy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0805546105"}], "href": "https://doi.org/10.1073/pnas.0805546105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18820033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18820033"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Lingjiao Meng, Yang Zheng, Sihua Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZEB1 represses biogenesis of circ-DOCK5 to facilitate metastasis in esophageal squamous cell carcinoma via a positive feedback loop with TGF-β."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2021.06.026"}], "href": "https://doi.org/10.1016/j.canlet.2021.06.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34216686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34216686"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Bekim Sadikovic, Paul Thorner, Susan Chilton-Macneill, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-10-202"}], "href": "https://doi.org/10.1186/1471-2407-10-202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20465837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20465837"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Alberto Gonzalez-Aguilar, Ahmed Idbaih, Blandine Boisselier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recurrent mutations of MYD88 and TBL1XR1 in primary central nervous system lymphomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-12-0845"}], "href": "https://doi.org/10.1158/1078-0432.CCR-12-0845"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22837180"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22837180"}]}]}]}
Proteins	DOCK5_HUMAN
NCBI Gene ID	80005
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DOCK5 has 12,241 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 122 datasets.

Click the + buttons to view associations for DOCK5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DOCK5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by DOCK5 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DOCK5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DOCK5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DOCK5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DOCK5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DOCK5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DOCK5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DOCK5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DOCK5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of DOCK5 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DOCK5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DOCK5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with DOCK5 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DOCK5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DOCK5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DOCK5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DOCK5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing DOCK5 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DOCK5 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DOCK5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing DOCK5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing DOCK5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DOCK5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DOCK5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DOCK5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DOCK5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with DOCK5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with DOCK5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with DOCK5 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of DOCK5 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by DOCK5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with DOCK5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DOCK5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DOCK5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DOCK5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with DOCK5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DOCK5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DOCK5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DOCK5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing DOCK5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.