DRAM1 Gene

Name	DNA-damage regulated autophagy modulator 1
Description	This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DRAM1 (damage‐regulated autophagy modulator 1) is emerging as a critical mediator linking stress signals to both autophagy and apoptosis. Many studies have shown that DRAM1 is a p53‐inducible lysosomal protein that enhances macroautophagy and is essential for p53‐mediated programmed cell death."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition to its key function in facilitating autophagy‐dependent cell death, DRAM1 also contributes to selective autophagic defense against intracellular pathogens in a p53‐independent manner."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " DRAM1 further cooperates with other pro‐apoptotic regulators—for example, by working together with ASPP2 to promote autophagic apoptosis—and has been reported to modulate the turnover of proteins such as BAX by preventing its autophagic degradation, thereby prolonging its half‐life and recruiting it to lysosomes where it triggers cell death cascades."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, DRAM1 expression is subjected to regulation by microRNAs—as exemplified by miR‑199a‑5p—in a context‐dependent fashion that alters its impact on autophagy in cancer cells"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and in certain sarcoma models, DRAM1 is upregulated via signaling pathways involving p53 and JNK, thereby enhancing both apoptotic and autophagic responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " DRAM1 is also implicated in the cellular response to environmental stressors such as particulate matter, where its p53‐dependent induction is necessary for autophagy‐mediated modulation of proinflammatory signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Its role in facilitating autophagy flux is linked to promoting lysosomal acidification and the efficient clearance of autophagosomes following mitochondrial dysfunction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Evolutionary comparisons have highlighted that DRAM1 possesses distinct functional properties compared to its homologues, with a specific and conserved connection to autophagy regulation in higher eukaryotes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In disease contexts, altered DRAM1 expression is linked to pathological conditions such as corneal dystrophy, where upregulation is associated with endoplasmic reticulum stress and increased autophagy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Furthermore, DRAM1 has been shown to modulate intracellular signaling pathways—specifically affecting PI3K–Akt–mTOR activity via regulation of growth factor receptor phosphorylation—thus connecting autophagy with cell viability and tumor suppressive processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Finally, alternative splicing generates DRAM1 isoforms with distinct subcellular distributions (for instance, lysosomal versus peroxisomal or autophagosomal localizations), suggesting that DRAM1 variants may fine‐tune autophagic responses under different cellular conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore DRAM1 as a multifaceted regulator that integrates stress responses by modulating autophagic flux, lysosomal function, and apoptotic signaling. Through its roles downstream of p53 and other signaling pathways, DRAM1 impacts tumor suppression, innate immunity, and cellular homeostasis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Diane Crighton, Simon Wilkinson, Jim O'Prey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DRAM, a p53-induced modulator of autophagy, is critical for apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2006.05.034"}], "href": "https://doi.org/10.1016/j.cell.2006.05.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16839881"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16839881"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Diane Crighton, Simon Wilkinson, Kevin M Ryan "}, {"type": "b", "children": [{"type": "t", "text": "DRAM links autophagy to p53 and programmed cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/auto.3438"}], "href": "https://doi.org/10.4161/auto.3438"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17102582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17102582"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Michiel van der Vaart, Cornelis J Korbee, Gerda E M Lamers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The DNA damage-regulated autophagy modulator DRAM1 links mycobacterial recognition via TLR-MYD88 to autophagic defense [corrected]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Host Microbe (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.chom.2014.05.005"}], "href": "https://doi.org/10.1016/j.chom.2014.05.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24922577"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24922577"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "K Liu, Y Shi, X Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CHOP mediates ASPP2-induced autophagic apoptosis in hepatoma cells by releasing Beclin-1 from Bcl-2 and inducing nuclear translocation of Bcl-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2014.276"}], "href": "https://doi.org/10.1038/cddis.2014.276"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25032846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25032846"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "J-J Guan, X-D Zhang, W Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2014.546"}], "href": "https://doi.org/10.1038/cddis.2014.546"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25633293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25633293"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Heqing Yi, Bing Liang, Jie Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential roles of miR-199a-5p in radiation-induced autophagy in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2012.12.027"}], "href": "https://doi.org/10.1016/j.febslet.2012.12.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23337876"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23337876"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Séverine Lorin, Amélie Borges, Lisandra Ribeiro Dos Santos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "c-Jun NH2-terminal kinase activation is essential for DRAM-dependent induction of autophagy and apoptosis in 2-methoxyestradiol-treated Ewing sarcoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-1270"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-1270"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19706754"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19706754"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xiuduan Xu, Hongli Wang, Shasha Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TP53-dependent autophagy links the ATR-CHEK1 axis activation to proinflammatory VEGFA production in human bronchial epithelial cells exposed to fine particulate matter (PM2.5)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2016.1204496"}], "href": "https://doi.org/10.1080/15548627.2016.1204496"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27463284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27463284"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xing-Ding Zhang, Lin Qi, Jun-Chao Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DRAM1 regulates autophagy flux through lysosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0063245"}], "href": "https://doi.org/10.1371/journal.pone.0063245"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23696801"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23696801"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jim O'Prey, Joanna Skommer, Simon Wilkinson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.8.14.9050"}], "href": "https://doi.org/10.4161/cc.8.14.9050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19556885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19556885"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Huan Meng, Mario Matthaei, Narendrakumar Ramanan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "L450W and Q455K Col8a2 knock-in mouse models of Fuchs endothelial corneal dystrophy show distinct phenotypes and evidence for altered autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Invest Ophthalmol Vis Sci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1167/iovs.12-11021"}], "href": "https://doi.org/10.1167/iovs.12-11021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23422828"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23422828"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Mireille Laforge, Sophie Limou, Francis Harper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DRAM triggers lysosomal membrane permeabilization and cell death in CD4(+) T cells infected with HIV."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1003328"}], "href": "https://doi.org/10.1371/journal.ppat.1003328"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23658518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23658518"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ting Lu, Zhou Zhu, Junchao Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DRAM1 regulates autophagy and cell proliferation via inhibition of the phosphoinositide 3-kinase-Akt-mTOR-ribosomal protein S6 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Commun Signal (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12964-019-0341-7"}], "href": "https://doi.org/10.1186/s12964-019-0341-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30902093"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30902093"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Li Yen Mah, Jim O'Prey, Alice D Baudot, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DRAM-1 encodes multiple isoforms that regulate autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/auto.8.1.18077"}], "href": "https://doi.org/10.4161/auto.8.1.18077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22082963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22082963"}]}]}]}
Synonyms	DRAM
Proteins	DRAM1_HUMAN
NCBI Gene ID	55332
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DRAM1 has 7,811 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 106 datasets.

Click the + buttons to view associations for DRAM1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DRAM1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DRAM1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DRAM1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DRAM1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DRAM1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DRAM1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DRAM1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DRAM1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DRAM1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DRAM1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DRAM1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DRAM1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DRAM1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DRAM1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DRAM1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DRAM1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DRAM1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DRAM1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing DRAM1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DRAM1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DRAM1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DRAM1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DRAM1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with DRAM1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with DRAM1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by DRAM1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with DRAM1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with DRAM1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DRAM1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DRAM1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DRAM1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with DRAM1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DRAM1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DRAM1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DRAM1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing DRAM1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of DRAM1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with DRAM1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing DRAM1 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of DRAM1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of DRAM1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.