{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although none of the provided abstracts discusses DRC3 explicitly, several studies examining related components of the nexin‐dynein regulatory complex (N‐DRC) provide insights into how DRC3 may function. For example, one study showed that mutations in DRC1—a key N‐DRC subunit—severely disrupt the assembly of this regulatory complex and lead to defective ciliary movement, underscoring the importance of N‐DRC integrity for proper dynein arm coordination and ciliary beating."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a related investigation, disruption of another N‐DRC component, DRC7, resulted in disorganized axonemal structures and immotile flagella, demonstrating that individual DRC subunits are critical for stabilizing the axoneme and ensuring normal motile cilia function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, studies on dynein axonemal assembly factors (such as DYX1C1, re‐designated DNAAF4) further reinforce that the proper assembly of dynein arms is essential for ciliary motility"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", a concept supported by recent comprehensive reviews of ciliary macro‐complex composition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In light of these findings, it is reasonable to infer that DRC3, as another constituent of the N‐DRC, likely plays a similar role in coordinating the assembly and regulatory functions of dynein motors. Its activity may contribute to maintaining axonemal integrity and ensuring the proper interaction of dynein arms with microtubule doublets, thereby facilitating effective ciliary and flagellar motility. Loss or dysfunction of DRC3 would be expected to perturb these processes, much like mutations in other DRC subunits, potentially leading to conditions such as primary ciliary dyskinesia.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Maureen Wirschell, Heike Olbrich, Claudius Werner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.2533"}], "href": "https://doi.org/10.1038/ng.2533"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23354437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23354437"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Akane Morohoshi, Haruhiko Miyata, Keisuke Shimada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1008585"}], "href": "https://doi.org/10.1371/journal.pgen.1008585"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31961863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31961863"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Aarti Tarkar, Niki T Loges, Christopher E Slagle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DYX1C1 is required for axonemal dynein assembly and ciliary motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.2707"}], "href": "https://doi.org/10.1038/ng.2707"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23872636"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23872636"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Anna Osinka, Martyna Poprzeczko, Magdalena M Zielinska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ciliary Proteins: Filling the Gaps. Recent Advances in Deciphering the Protein Composition of Motile Ciliary Complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells8070730"}], "href": "https://doi.org/10.3390/cells8070730"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31319499"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31319499"}]}]}]}