{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DRICH1 has been implicated in a variety of cellular processes across different model systems. In Drosophila, the homolog dRich acts as a Cdc42‐selective GTPase-activating protein that inhibits the Cdc42-Wsp pathway to promote postsynaptic release of the Gbb ligand at the neuromuscular junction, thereby coordinating synaptic growth and neurotransmission."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In mammals, DRICH1 has emerged from multiple studies as a multifunctional protein with diverse roles. It has been identified as one of several hub genes associated with abnormal coronary endothelial function, where its expression correlates with immune response, coagulation, hypoxia, and angiogenesis pathways, suggesting a possible role in the early stages of coronary atherosclerosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In the context of cancer, DRICH1 was found to exhibit high enrichment for the transcription factor TCF4 in cutaneous squamous cell carcinoma cells, implicating it in tumorigenesis through a Wnt/β-catenin–independent mechanism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, a genome-scale CRISPR loss-of-function screen in human pluripotent stem cells identified DRICH1 (alias C22orf43) as an essential gene for cell fitness, highlighting its importance in fundamental processes of stem cell biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Finally, proteomic analyses have confirmed that DRICH1 is a bona fide human N-myristoylated protein, suggesting that its post-translational modification might be critical for its proper intracellular localization and function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that DRICH1 is a multifunctional protein involved in the regulation of synaptogenesis, endothelial function, cellular fitness in stem cells, and tumorigenesis. Its activity appears to be modulated by post-translational modifications and context-dependent interactions, reflecting its diverse roles in cellular physiology.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Minyeop Nahm, A Ashleigh Long, Sang Kyoo Paik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Cdc42-selective GAP rich regulates postsynaptic development and retrograde BMP transsynaptic signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201007086"}], "href": "https://doi.org/10.1083/jcb.201007086"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21041451"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21041451"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xue Qiu, Jinyan Lin, Yanbing Chen, et al. 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