DUSP14 Gene

HGNC Family	Phosphatases
Name	dual specificity phosphatase 14
Description	Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Dual‐specificity phosphatase 14 (DUSP14) is an atypical MAPK phosphatase that controls signaling cascades by dephosphorylating key intermediates, thereby modulating diverse cellular responses. In T cells, DUSP14 negatively regulates antigen‐receptor signaling by dephosphorylating TAB1, which in turn attenuates TAK1, JNK, and NF‐κB activation and limits immune responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In pulmonary tuberculosis, genetic studies have implicated DUSP14 as a susceptibility gene, with low‐expression alleles correlating with enhanced Th1 responses and protection against active disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In pancreatic beta‐cells, DUSP14 is rapidly induced by glucagon‐like peptide‐1 and functions as a negative regulator of cell proliferation, such that its suppression augments beta‐cell expansion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Conversely, in breast cancer, exosomal delivery of miRNAs that target DUSP14 contributes to tumorigenic processes by downregulating this putative tumor suppressor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In the cardiovascular system, DUSP14 protects against pressure overload–induced cardiac hypertrophy by deactivating the TAK1–p38MAPK/JNK signaling axis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", while in the liver it maintains metabolic homeostasis and suppresses inflammation in nonalcoholic fatty liver disease through similar mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In the nervous system, deletion of DUSP14 enhances ERK1/2 activation and promotes retinal ganglion cell survival following ischemic injury"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", and in the heart, elevated DUSP14 levels reduce oxidative stress and inflammatory signaling during ischemia–reperfusion injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Finally, pharmacological upregulation of DUSP14 by eriocitrin ameliorates renal ischemia–reperfusion injury by dampening both oxidative stress and inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight DUSP14 as a critical negative regulator of MAPK signaling with multifaceted roles in modulating immune responses, cell proliferation and survival, as well as in protecting tissues from metabolic and ischemic stresses.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chia-Yu Yang, Ju-Pi Li, Li-Li Chiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1300989"}], "href": "https://doi.org/10.4049/jimmunol.1300989"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24403530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24403530"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chia-Yu Yang, Li-Li Chiu, Tse-Hua Tan "}, {"type": "b", "children": [{"type": "t", "text": "TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2015.10.017"}], "href": "https://doi.org/10.1016/j.cellsig.2015.10.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26521044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26521044"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Luis B Barreiro, Ludovic Tailleux, Athma A Pai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1115761109"}], "href": "https://doi.org/10.1073/pnas.1115761109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22233810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22233810"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "M Hijikata, I Matsushita, N T Le Hang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Influence of the polymorphism of the DUSP14 gene on the expression of immune-related genes and development of pulmonary tuberculosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Immun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/gene.2016.11"}], "href": "https://doi.org/10.1038/gene.2016.11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26938665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26938665"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sonia Klinger, Carine Poussin, Marie-Bernard Debril, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db07-1414"}], "href": "https://doi.org/10.2337/db07-1414"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18025410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18025410"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Vahid Kia, Mahdi Paryan, Yousef Mortazavi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evaluation of exosomal miR-9 and miR-155 targeting PTEN and DUSP14 in highly metastatic breast cancer and their effect on low metastatic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27850"}], "href": "https://doi.org/10.1002/jcb.27850"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30335891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30335891"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chang-Yi Li, Qing Zhou, Ling-Chao Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Basic Res Cardiol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00395-016-0536-7"}], "href": "https://doi.org/10.1007/s00395-016-0536-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26891723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26891723"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Siyuan Wang, Zhen-Zhen Yan, Xia Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatocyte DUSP14 maintains metabolic homeostasis and suppresses inflammation in the liver."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.29616"}], "href": "https://doi.org/10.1002/hep.29616"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29077210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29077210"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Varun Kumar, Mohammad Ali Shariati, Louise Mesentier-Louro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dual Specific Phosphatase 14 Deletion Rescues Retinal Ganglion Cells and Optic Nerve Axons after Experimental Anterior Ischemic Optic Neuropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Eye Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/02713683.2020.1826976"}], "href": "https://doi.org/10.1080/02713683.2020.1826976"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33107352"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33107352"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Song Jianrong, Zhao Yanjun, Yu Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DUSP14 rescues cerebral ischemia/reperfusion (IR) injury by reducing inflammation and apoptosis via the activation of Nrf-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.12.170"}], "href": "https://doi.org/10.1016/j.bbrc.2018.12.170"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30638656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30638656"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jun Xu, Liang Ma, Ping Fu "}, {"type": "b", "children": [{"type": "t", "text": "Eriocitrin attenuates ischemia reperfusion-induced oxidative stress and inflammation in rats with acute kidney injury by regulating the dual-specificity phosphatase 14 (DUSP14)-mediated Nrf2 and nuclear factor-κB (NF-κB) pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Transl Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21037/atm-21-337"}], "href": "https://doi.org/10.21037/atm-21-337"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33708977"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33708977"}]}]}]}
Synonyms	MKP-L, MKP6
Proteins	DUS14_HUMAN
NCBI Gene ID	11072
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DUSP14 has 7,384 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 113 datasets.

Click the + buttons to view associations for DUSP14 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DUSP14 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DUSP14 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DUSP14 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DUSP14 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DUSP14 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DUSP14 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DUSP14 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DUSP14 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DUSP14 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DUSP14 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of DUSP14 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DUSP14 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DUSP14 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DUSP14 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DUSP14 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DUSP14 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DUSP14 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing DUSP14 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DUSP14 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing DUSP14 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing DUSP14 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DUSP14 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DUSP14 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DUSP14 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DUSP14 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with DUSP14 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with DUSP14 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with DUSP14 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of DUSP14 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by DUSP14 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with DUSP14 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DUSP14 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DUSP14 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DUSP14 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with DUSP14 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DUSP14 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DUSP14 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DUSP14 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing DUSP14 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with DUSP14 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with DUSP14 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.