{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPseudogene‐derived long noncoding RNA DUXAP8 is emerging as a potent oncogenic regulator in several human malignancies. In esophageal, bladder, pancreatic cancers and neuroblastoma, DUXAP8 is frequently upregulated, where it promotes cell proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, DUXAP8 functions chiefly as a competing endogenous RNA that “sponges” tumor‐suppressive microRNAs, thereby relieving repression of oncogenic targets and facilitating aggressive growth and poor patient outcomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn additional cancer types, including studies in renal cell carcinoma models and colorectal cancer, as well as in hepatocellular carcinoma, upregulation of DUXAP8 contributes to malignant transformation by interacting with specific microRNAs and epigenetic modifiers. In these contexts, DUXAP8 has been associated with the dysregulation of pathways involved in cell cycle progression and differentiation, further underscoring its role in tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDUXAP8’s oncogenic influence extends to cancers of the thyroid, ovary, breast and lung, and even to non-malignant inflammatory conditions such as pulpitis. In papillary thyroid and ovarian cancers, for instance, DUXAP8 appears to drive cell cycle progression and metastatic behavior through microRNA-mediated derepression of targets like SOS1, YAP1 and TOP2A, while in luminal breast cancer and non‐small cell lung cancer its elevated expression correlates with advanced disease and reduced survival. These studies collectively support DUXAP8 as a promising biomarker and potential therapeutic target across a spectrum of human disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "12"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "L-J Xu, X-J Yu, B Wei, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "ACC1 (Acetyl Coenzyme A Carboxylase 1) Is a Potential Immune Modulatory Target of Cerebral Ischemic Stroke."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stroke (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/STROKEAHA.119.024564"}], "href": "https://doi.org/10.1161/STROKEAHA.119.024564"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31177975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31177975"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jing Chen, Weiyang Lou, Bisha Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpressed pseudogenes, DUXAP8 and DUXAP9, promote growth of renal cell carcinoma and serve as unfavorable prognostic biomarkers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.102152"}], "href": "https://doi.org/10.18632/aging.102152"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31409759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31409759"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Aifeng Gong, Ziming Huang, Hengfa Ge, et al. 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