DYNAP Gene

Name	dynactin associated protein
Description	Involved in several processes, including activation of protein kinase B activity; cellular response to ergosterol; and positive regulation of cell population proliferation. Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DynAP (dynactin‐associated protein) is a single‐pass transmembrane protein that has been implicated in oncogenic cell signaling and transformation. It localizes, in a microtubule‐dependent manner, to the Golgi apparatus and the plasma membrane, and its expression is frequently elevated in cancer cells compared to normal fibroblasts. Functional studies have shown that DynAP interacts with components of the dynactin complex and promotes Akt activation via enhanced Ser⁴⁷³ phosphorylation, which appears to sustain high proliferation rates in tumor cells. Inhibition of DynAP function using ergosterol‐related compounds not only abrogates Akt activation but also induces apoptosis, suggesting that DynAP contributes to cancer cell survival and could represent a promising therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, studies utilizing overexpression in NIH3T3 cells have demonstrated that the extracellular carboxy‐terminal region of DynAP, which undergoes specific N- and O-linked glycosylation, is essential both for its proper targeting to the plasma membrane and for its transforming activity. An additional layer of complexity is added by the existence of multiple isoforms arising from alternative splicing, which may have differential roles in DynAP’s cellular functions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tatsuki Kunoh, Takanori Noda, Koichi Koseki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Ther (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1535-7163.MCT-10-0730"}], "href": "https://doi.org/10.1158/1535-7163.MCT-10-0730"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20978158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20978158"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaobo Yin, Takayuki Konishi, Kazuo Horikawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure and Function of Potential Glycosylation Sites of Dynactin-Associated Protein dynAP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biotechnol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12033-021-00435-3"}], "href": "https://doi.org/10.1007/s12033-021-00435-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35022995"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35022995"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaobo Yin, Shota Yamada, Hiroaki Kobayashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and cell transformation activity of dynactin-associated protein isoforms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Open Bio (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/2211-5463.13202"}], "href": "https://doi.org/10.1002/2211-5463.13202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34043884"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34043884"}]}]}]}
Synonyms	C18ORF26
Proteins	DYNAP_HUMAN
NCBI Gene ID	284254
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DYNAP has 1,965 functional associations with biological entities spanning 7 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 53 datasets.

Click the + buttons to view associations for DYNAP from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DYNAP Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DYNAP gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DYNAP gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DYNAP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DYNAP gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DYNAP gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DYNAP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DYNAP gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DYNAP gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DYNAP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DYNAP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of DYNAP gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DYNAP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing DYNAP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DYNAP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DYNAP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DYNAP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by DYNAP gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DYNAP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DYNAP gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DYNAP gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DYNAP gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with DYNAP gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing DYNAP from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of DYNAP gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GO Biological Process Annotations 2015	biological processes involving DYNAP gene from the curated GO Biological Process Annotations 2015 dataset.
	GO Biological Process Annotations 2023	biological processes involving DYNAP gene from the curated GO Biological Process Annotations 2023 dataset.
	GO Biological Process Annotations 2025	biological processes involving DYNAP gene from the curated GO Biological Process Annotations2025 dataset.
	GO Cellular Component Annotations 2015	cellular components containing DYNAP protein from the curated GO Cellular Component Annotations 2015 dataset.
	GO Molecular Function Annotations 2015	molecular functions performed by DYNAP gene from the curated GO Molecular Function Annotations 2015 dataset.
	GTEx eQTL 2025	SNPs regulating expression of DYNAP gene from the GTEx eQTL 2025 dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of DYNAP gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	GTEx Tissue Gene Expression Profiles 2023	tissues with high or low expression of DYNAP gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
	GWAS Catalog SNP-Phenotype Associations 2025	phenotypes associated with DYNAP gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
	HPA Tissue Protein Expression Profiles	tissues with high or low expression of DYNAP protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
	HuBMAP Azimuth Cell Type Annotations	cell types associated with DYNAP gene from the HuBMAP Azimuth Cell Type Annotations dataset.
	JASPAR Predicted Human Transcription Factor Targets 2025	transcription factors regulating expression of DYNAP gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
	JASPAR Predicted Transcription Factor Targets	transcription factors regulating expression of DYNAP gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of DYNAP gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
	LOCATE Predicted Protein Localization Annotations	cellular components predicted to contain DYNAP protein from the LOCATE Predicted Protein Localization Annotations dataset.
	MotifMap Predicted Transcription Factor Targets	transcription factors regulating expression of DYNAP gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
	PFOCR Pathway Figure Associations 2024	pathways involving DYNAP protein from the Wikipathways PFOCR 2024 dataset.
	Roadmap Epigenomics Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DYNAP gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
	Rummagene Transcription Factor Associations 2026	transcription factors regulating expression of DYNAP gene from the Rummagene Transcription Factor Associations 2026 dataset.
	RummaGEO Drug Perturbation Signatures	drug perturbations changing expression of DYNAP gene from the RummaGEO Drug Perturbation Signatures dataset.
	RummaGEO Gene Perturbation Signatures	gene perturbations changing expression of DYNAP gene from the RummaGEO Gene Perturbation Signatures dataset.
	TargetScan Predicted Conserved microRNA Targets	microRNAs regulating expression of DYNAP gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
	TargetScan Predicted Nonconserved microRNA Targets	microRNAs regulating expression of DYNAP gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
	TCGA Signatures of Differentially Expressed Genes for Tumors	tissue samples with high or low expression of DYNAP gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
	TISSUES Curated Tissue Protein Expression Evidence Scores	tissues with high expression of DYNAP protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	tissues with high expression of DYNAP protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	tissues with high expression of DYNAP protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores	tissues co-occuring with DYNAP protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	tissues co-occuring with DYNAP protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.