DYNLRB1 Gene

HGNC Family	Dyneins
Name	dynein, light chain, roadblock-type 1
Description	This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DYNLRB1, a dynein light chain of the roadblock/LC7 family, has emerged as a multifunctional regulatory subunit integral to diverse dynein motor complexes. Acting in both the cytoplasmic and ciliary dynein systems, DYNLRB1 directly contributes to the regulation of intracellular trafficking and organelle positioning. For example, it interacts with Rab6 GTPases at the Golgi, thereby facilitating retrograde vesicular transport between the Golgi and endoplasmic reticulum."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the context of ciliary function, DYNLRB1 is incorporated into the dynein‐2 complex through its association with the WDR34 intermediate chain, a relationship that is critical for retrograde protein trafficking within cilia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its structural role in motor assembly, recent studies have underscored the broader physiological significance of DYNLRB1 in neuronal systems. It is essential for general dynein-mediated transport that underpins axonal trafficking of lysosomes and retrograde signaling endosomes, thereby supporting sensory neuron survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, interactions between DYNLRB1 and N-acetylglucosamine kinase (NAGK) reveal additional functions in promoting axo-dendritic growth and in facilitating the clearance of toxic protein aggregates associated with neurodegenerative disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, DYNLRB1 has been identified as an interacting partner of the reduced folate carrier (RFC), where its coexpression enhances folate uptake, suggesting a contributory role in nutrient transport and cellular metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Collectively, these observations position DYNLRB1 as a pivotal adapter within dynein complexes that ensures proper intracellular and ciliary transport, supports neuronal integrity, and even influences metabolic processes. Its diverse interactions and essential functions in retrograde trafficking thus have significant implications for understanding both normal cellular homeostasis and the pathogenesis of neurodegenerative diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bas Wanschers, Rinske van de Vorstenbosch, Mietske Wijers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab6 family proteins interact with the dynein light chain protein DYNLRB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Motil Cytoskeleton (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cm.20254"}], "href": "https://doi.org/10.1002/cm.20254"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18044744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18044744"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuki Hamada, Yuta Tsurumi, Shohei Nozaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of WDR60 intermediate chain with TCTEX1D2 light chain of the dynein-2 complex is crucial for ciliary protein trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E18-03-0173"}], "href": "https://doi.org/10.1091/mbc.E18-03-0173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29742051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29742051"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yuta Tsurumi, Yuki Hamada, Yohei Katoh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interactions of the dynein-2 intermediate chain WDR34 with the light chains are required for ciliary retrograde protein trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E18-10-0678"}], "href": "https://doi.org/10.1091/mbc.E18-10-0678"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30649997"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30649997"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Marco Terenzio, Agostina Di Pizio, Ida Rishal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DYNLRB1 is essential for dynein mediated transport and neuronal survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nbd.2020.104816"}], "href": "https://doi.org/10.1016/j.nbd.2020.104816"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32088381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32088381"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Md Kamal Hossain Ripon, HyunSook Lee, Raju Dash, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-02862-7"}], "href": "https://doi.org/10.1038/s41419-020-02862-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32796833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32796833"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Syeda Ridita Sharif, Ariful Islam, Il Soo Moon "}, {"type": "b", "children": [{"type": "t", "text": "N-Acetyl-D-Glucosamine Kinase Interacts with Dynein-Lis1-NudE1 Complex and Regulates Cell Division."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cells (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14348/molcells.2016.0119"}], "href": "https://doi.org/10.14348/molcells.2016.0119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27646688"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27646688"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Balasubramaniem Ashokkumar, Svetlana M Nabokina, Thomas Y Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of dynein light chain road block-1 as a novel interaction partner with the human reduced folate carrier."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Gastrointest Liver Physiol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpgi.00154.2009"}], "href": "https://doi.org/10.1152/ajpgi.00154.2009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19571232"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19571232"}]}]}]}
Synonyms	BLP, BITH, DNCL2A, ROBLD1, DNLC2A
Proteins	DLRB1_HUMAN
NCBI Gene ID	83658
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DYNLRB1 has 7,498 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 118 datasets.

Click the + buttons to view associations for DYNLRB1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DYNLRB1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DYNLRB1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DYNLRB1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DYNLRB1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DYNLRB1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DYNLRB1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DYNLRB1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DYNLRB1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DYNLRB1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DYNLRB1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of DYNLRB1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DYNLRB1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DYNLRB1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with DYNLRB1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DYNLRB1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DYNLRB1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DYNLRB1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DYNLRB1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of DYNLRB1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DYNLRB1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DYNLRB1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing DYNLRB1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing DYNLRB1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DYNLRB1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DYNLRB1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DYNLRB1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DYNLRB1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with DYNLRB1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with DYNLRB1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of DYNLRB1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with DYNLRB1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DYNLRB1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DYNLRB1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DYNLRB1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with DYNLRB1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DYNLRB1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DYNLRB1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DYNLRB1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing DYNLRB1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of DYNLRB1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with DYNLRB1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.