DYNLT1 Gene

HGNC Family	Dyneins
Name	dynein, light chain, Tctex-type 1
Description	This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n DYNLT1 (also known as Tctex‐1) is a multifunctional light‐chain subunit of cytoplasmic dynein that plays diverse roles in both motor‐dependent and motor‐independent processes. As an integral part of the dynein complex, DYNLT1 mediates the retrograde transport of specific cargoes such as membrane proteins and viral particles. For example, its direct binding to receptor cytoplasmic domains—including the poliovirus receptor CD155 and the human voltage‐dependent anion channel VDAC1—facilitates the microtubule‐dependent delivery of virus‐containing endocytic vesicles to the cell body (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " Similarly, during human papillomavirus infection, DYNLT1 interacts with the viral L2 capsid protein to promote transport toward the nucleus"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", and a comparable mechanism is used by Chlamydia trachomatis proteins to ensure proper inclusion positioning at the microtubule organizing center."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in pathogen trafficking, DYNLT1 is critical for regulating cellular dynamics. Phosphorylated Tctex‐1 is recruited to the ciliary transition zone where it triggers cilium disassembly and couples this event to S‐phase entry."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In vascular smooth muscle, DYNLT1 interacts with the cytoplasmic domain of BMPR‐II and is phosphorylated by this receptor, indicating a role in modulating signaling pathways relevant to cell proliferation and motility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In neural cells, DYNLT1 exerts noncanonical functions that impact cell fate. By antagonizing the activity of the Rho guanine nucleotide exchange factor Lfc, Tctex‐1 helps govern spindle orientation during mitosis and influences the timing of neuronal differentiation in cortical progenitors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Further, interactions between DYNLT1 and Gβγ subunits regulate neurite outgrowth in a dynein‐independent manner, highlighting its role in cytoskeletal remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, DYNLT1 serves as a docking partner for several regulatory proteins involved in microtubule organization and signaling. Its binding to tastin helps target membrane‐associated complexes to microtubules and contributes to proper spindle assembly during mitosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In G protein–coupled receptor signaling, displacement of GEF‐H1 from its association with Tctex‐1 is a key step in activating Rho signaling"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", and structural studies of the dynein–2 complex indicate that DYNLT1 (together with its homologs) contributes to the proper assembly and function of retrograde intraflagellar transport."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies demonstrate that DYNLT1/Tctex‐1 is a key determinant in linking dynein to distinct cargos and regulatory pathways, thereby orchestrating a wide range of cellular events—from virus and protein trafficking to ciliary dynamics, spindle organization, and cytoskeletal remodeling.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Steffen Mueller, Xuemei Cao, Reinhold Welker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111937200"}], "href": "https://doi.org/10.1074/jbc.M111937200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11751937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11751937"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Christian Schwarzer, Shitsu Barnikol-Watanabe, Friedrich P Thinnes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1357-2725(02)00026-2"}], "href": "https://doi.org/10.1016/s1357-2725(02"}, {"type": "t", "text": "00026-2) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12009301"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12009301"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Seii Ohka, Norie Matsuda, Koujiro Tohyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.78.13.7186-7198.2004"}], "href": "https://doi.org/10.1128/JVI.78.13.7186-7198.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15194795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15194795"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Marc A Schneider, Gilles A Spoden, Luise Florin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the dynein light chains required for human papillomavirus infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Microbiol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1462-5822.2010.01515.x"}], "href": "https://doi.org/10.1111/j.1462-5822.2010.01515.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21166973"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21166973"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jeffrey Mital, Erika I Lutter, Alexandra C Barger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chlamydia trachomatis inclusion membrane protein CT850 interacts with the dynein light chain DYNLT1 (Tctex1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.04.116"}], "href": "https://doi.org/10.1016/j.bbrc.2015.04.116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25944661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25944661"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Aiqun Li, Masaki Saito, Jen-Zen Chuang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2218"}], "href": "https://doi.org/10.1038/ncb2218"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21394082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21394082"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Rajiv D Machado, Nung Rudarakanchana, Carl Atkinson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddg365"}], "href": "https://doi.org/10.1093/hmg/ddg365"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14583445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14583445"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Andrée Gauthier-Fisher, Dan C Lin, Melissa Greeve, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Neurosci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nn.2339"}], "href": "https://doi.org/10.1038/nn.2339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19448628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19448628"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Pallavi Sachdev, Santosh Menon, David B Kastner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "G protein beta gamma subunit interaction with the dynein light-chain component Tctex-1 regulates neurite outgrowth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601716"}], "href": "https://doi.org/10.1038/sj.emboj.7601716"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17491591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17491591"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Daita Nadano, Jun Nakayama, Shu-Ichi Matsuzawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human tastin, a proline-rich cytoplasmic protein, associates with the microtubular cytoskeleton."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20011836"}], "href": "https://doi.org/10.1042/BJ20011836"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12049630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12049630"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Shuo Yang, Xuan Liu, Yanqing Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tastin is required for bipolar spindle assembly and centrosome integrity during mitosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.07-081463"}], "href": "https://doi.org/10.1096/fj.07-081463"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18218922"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18218922"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "David Meiri, Christopher B Marshall, Daphna Mokady, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanistic insight into GPCR-mediated activation of the microtubule-associated RhoA exchange factor GEF-H1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms5857"}], "href": "https://doi.org/10.1038/ncomms5857"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25209408"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25209408"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yuki Hamada, Yuta Tsurumi, Shohei Nozaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of WDR60 intermediate chain with TCTEX1D2 light chain of the dynein-2 complex is crucial for ciliary protein trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E18-03-0173"}], "href": "https://doi.org/10.1091/mbc.E18-03-0173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29742051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29742051"}]}]}]}
Synonyms	CW-1, TCTEL1, TCTEX-1
Proteins	DYLT1_HUMAN
NCBI Gene ID	6993
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

DYNLT1 has 6,466 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 111 datasets.

Click the + buttons to view associations for DYNLT1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

DYNLT1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DYNLT1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of DYNLT1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of DYNLT1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of DYNLT1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of DYNLT1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of DYNLT1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of DYNLT1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of DYNLT1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of DYNLT1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of DYNLT1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of DYNLT1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with DYNLT1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with DYNLT1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DYNLT1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of DYNLT1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of DYNLT1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of DYNLT1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing DYNLT1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing DYNLT1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with DYNLT1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with DYNLT1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of DYNLT1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with DYNLT1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with DYNLT1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of DYNLT1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by DYNLT1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with DYNLT1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with DYNLT1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with DYNLT1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with DYNLT1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with DYNLT1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at DYNLT1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of DYNLT1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of DYNLT1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing DYNLT1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of DYNLT1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with DYNLT1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing DYNLT1 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of DYNLT1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of DYNLT1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.