{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Endogenized bornavirus‐like nucleoprotein 1 (EBLN1) appears to have evolved beyond its viral origin to acquire novel cellular roles. In a genome‐wide association study of abdominal fat traits, a locus encompassing EBLN1 together with MLLT10 and DNAJC1 was associated with subcutaneous adipose tissue in women, suggesting a potential link with metabolic regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Functional studies in human oligodendroglial cells have demonstrated that silencing EBLN1 expression markedly reduces cell proliferation, induces a G2/M cell cycle arrest, and promotes apoptosis. These changes are accompanied by widespread alterations in gene expression, particularly affecting cell cycle, MAP kinase, p53, and apoptotic pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Complementary experiments further reveal that depletion of EBLN1 leads to the accumulation of DNA damage, cell cycle abnormalities, disorganized microtubule structure, and premature centrosome splitting – defects that appear to stem in part from mislocalization of key nuclear envelope proteins, thereby implicating EBLN1 as a novel regulator of genome stability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n At the evolutionary level, however, investigations into primate EBLN elements indicate that clear signatures of natural selection have not been observed since the divergence of Old World and New World monkeys. This suggests that while EBLN1’s cellular roles in proliferation, apoptosis, and genomic maintenance are supported by experimental evidence, its evolutionary conservation as a functional protein remains a subject for further study."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Y J Sung, L Pérusse, M A Sarzynski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association studies suggest sex-specific loci associated with abdominal and visceral fat."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Obes (Lond) (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ijo.2015.217"}], "href": "https://doi.org/10.1038/ijo.2015.217"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26480920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26480920"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Peng He, Lin Sun, Dan Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knock-Down of Endogenous Bornavirus-Like Nucleoprotein 1 Inhibits Cell Growth and Induces Apoptosis in Human Oligodendroglia Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms17040435"}], "href": "https://doi.org/10.3390/ijms17040435"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27023521"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27023521"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Katie N Myers, Giancarlo Barone, Anil Ganesh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The bornavirus-derived human protein EBLN1 promotes efficient cell cycle transit, microtubule organisation and genome stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep35548"}], "href": "https://doi.org/10.1038/srep35548"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27739501"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27739501"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yuki Kobayashi, Masayuki Horie, Keizo Tomonaga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "No evidence for natural selection on endogenous borna-like nucleoprotein elements after the divergence of Old World and New World monkeys."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0024403"}], "href": "https://doi.org/10.1371/journal.pone.0024403"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21912690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21912690"}]}]}]}