EDNRA Gene

HGNC Family	G protein-coupled receptors
Name	endothelin receptor type A
Description	This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Endothelin receptor type A (EDNRA) is a pivotal mediator of endothelin‐1 (ET‐1) signaling with diverse roles spanning from normal physiology to complex pathophysiological states. In vascular tissues, activation of EDNRA by ET‐1 controls vasoconstriction and myofibroblast contractility, thereby contributing to tissue repair and matrix remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n During development, EDNRA signaling in neural crest–derived cells is essential for proper craniofacial patterning. Studies in mutant models have demonstrated that loss or disruption of EDNRA leads to homeotic transformations of jaw structures and other craniofacial defects, underscoring its critical role in establishing mandibular versus maxillary identity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In adults, dysregulation of EDNRA contributes to multiple vascular and organ dysfunctions. Increased EDNRA expression in glomerular endothelial cells has been linked to mitochondrial oxidative stress and diabetic kidney injury, while augmented receptor activity is observed in pulmonary vasculature in association with elevated pulmonary pressures."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, genetic variants affecting EDNRA function have been associated with intracranial aneurysm susceptibility and with migraine risk, reflecting its influence on vascular wall tone and remodeling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In oncology, EDNRA signaling is co‐opted to promote tumor aggressiveness. In both bladder and ovarian carcinomas, ET‐1 acting via EDNRA enhances cell proliferation, invasiveness, angiogenesis, and even chemoresistance through β‐arrestin–dependent pathways and interactions with the Wnt/β‐catenin axis. These mechanisms not only facilitate epithelial–mesenchymal transition but also disrupt gap junctional communication, thereby fostering a microenvironment conducive to metastatic dissemination."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "15"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, in the ocular system, EDNRA has been implicated in the modulation of trabecular meshwork contractility and intraocular pressure. MicroRNA‐mediated regulation of EDNRA activity (for example, by miR‐200c) alters cell contractility, suggesting that selective targeting of EDNRA may have therapeutic potential in glaucoma management."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight EDNRA as a central node in ET‐1–mediated signaling. Its actions govern diverse processes including vascular tone regulation, tissue remodeling, neural crest–derived craniofacial morphogenesis, and tumor progression. The broad functional spectrum of EDNRA underscores its potential as a promising therapeutic target across vascular, developmental, renal, cardiac, oncologic, and ocular disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xu Shi-Wen, Yunliang Chen, Christopher P Denton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e03-12-0902"}], "href": "https://doi.org/10.1091/mbc.e03-12-0902"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15047866"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15047866"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Angelika Horstmeyer, Christoph Licht, Gabriele Scherr, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Signalling and regulation of collagen I synthesis by ET-1 and TGF-beta1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1742-4658.2005.05016.x"}], "href": "https://doi.org/10.1111/j.1742-4658.2005.05016.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16336267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16336267"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "J Charité, D G McFadden, G Merlo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.931701"}], "href": "https://doi.org/10.1101/gad.931701"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11711438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11711438"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Louis-Bruno Ruest, Xilin Xiang, Kim-Chew Lim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.01291"}], "href": "https://doi.org/10.1242/dev.01291"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15306564"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15306564"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Takahiro Sato, Yukiko Kurihara, Rieko Asai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An endothelin-1 switch specifies maxillomandibular identity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0807345105"}], "href": "https://doi.org/10.1073/pnas.0807345105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19017795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19017795"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xu Shi-Wen, Fernando Rodríguez-Pascual, Santiago Lamas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00625-06"}], "href": "https://doi.org/10.1128/MCB.00625-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16809784"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16809784"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Haiying Qi, Gabriella Casalena, Shaolin Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db16-0695"}], "href": "https://doi.org/10.2337/db16-0695"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27899487"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27899487"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Vladimir I Bushuev, Galina Y Miasnikova, Adelina I Sergueeva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endothelin-1, vascular endothelial growth factor and systolic pulmonary artery pressure in patients with Chuvash polycythemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2006)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16769575"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16769575"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Matthew J Grimshaw, Julia L Wilson, Frances R Balkwill "}, {"type": "b", "children": [{"type": "t", "text": "Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1521-4141(200209)32:9"}, {"type": "a", "children": [{"type": "t", "text": "2393::AID-IMMU2393"}], "href": "2393::AID-IMMU2393"}, {"type": "t", "text": "3.0.CO;2-4"}], "href": "https://doi.org/10.1002/1521-4141(200209"}, {"type": "t", "text": "32:9"}, {"type": "a", "children": [{"type": "t", "text": "2393::AID-IMMU2393"}], "href": "2393::AID-IMMU2393"}, {"type": "t", "text": "3.0.CO;2-4) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12207323"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12207323"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Tatiana Foroud, Daniel L Koller, Dongbing Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stroke (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/STROKEAHA.112.656397"}], "href": "https://doi.org/10.1161/STROKEAHA.112.656397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22961961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22961961"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Siew-Kee Low, Atsushi Takahashi, Pei-Chieng Cha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/dds020"}], "href": "https://doi.org/10.1093/hmg/dds020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22286173"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22286173"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Neveen Said, Steven Smith, Marta Sanchez-Carbayo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor endothelin-1 enhances metastatic colonization of the lung in mouse xenograft models of bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI42912"}], "href": "https://doi.org/10.1172/JCI42912"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21183790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21183790"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Francesca Spinella, Laura Rosanò, Valeriana Di Castro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endothelin-1-induced prostaglandin E2-EP2, EP4 signaling regulates vascular endothelial growth factor production and ovarian carcinoma cell invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M408584200"}], "href": "https://doi.org/10.1074/jbc.M408584200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15347673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15347673"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Laura Rosanò, Roberta Cianfrocca, Piera Tocci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endothelin A receptor/β-arrestin signaling to the Wnt pathway renders ovarian cancer cells resistant to chemotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-13-3133"}], "href": "https://doi.org/10.1158/0008-5472.CAN-13-3133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25377471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25377471"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Francesca Spinella, Laura Rosanò, Valeriana Di Castro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M304785200"}], "href": "https://doi.org/10.1074/jbc.M304785200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12907686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12907686"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Coralia Luna, Guorong Li, Jianyong Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of trabecular meshwork cell contraction and intraocular pressure by miR-200c."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0051688"}], "href": "https://doi.org/10.1371/journal.pone.0051688"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23272142"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23272142"}]}]}]}
Synonyms	ETA, HET-AR, ETAR, MFDA, ETA-R, ET-A, ETRA
Proteins	EDNRA_HUMAN
NCBI Gene ID	1909
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

EDNRA has 9,409 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 121 datasets.

Click the + buttons to view associations for EDNRA from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

EDNRA Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of EDNRA gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of EDNRA gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of EDNRA gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of EDNRA gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of EDNRA gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving EDNRA protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of EDNRA gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of EDNRA gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of EDNRA gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of EDNRA gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with EDNRA gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with EDNRA gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of EDNRA gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of EDNRA gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of EDNRA gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of EDNRA gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing EDNRA protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing EDNRA protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing EDNRA protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with EDNRA protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with EDNRA protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of EDNRA gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with EDNRA gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with EDNRA gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with EDNRA gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with EDNRA gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by EDNRA gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving EDNRA gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with EDNRA gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with EDNRA gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with EDNRA gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with EDNRA gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with EDNRA gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with EDNRA gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for EDNRA protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at EDNRA gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of EDNRA gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of EDNRA gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing EDNRA from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with EDNRA gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.