HGNC Family | G protein-coupled receptors |
Name | endothelin receptor type A |
Description | This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Endothelin receptor type A (EDNRA) is a pivotal mediator of endothelin‐1 (ET‐1) signaling with diverse roles spanning from normal physiology to complex pathophysiological states. In vascular tissues, activation of EDNRA by ET‐1 controls vasoconstriction and myofibroblast contractility, thereby contributing to tissue repair and matrix remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n During development, EDNRA signaling in neural crest–derived cells is essential for proper craniofacial patterning. Studies in mutant models have demonstrated that loss or disruption of EDNRA leads to homeotic transformations of jaw structures and other craniofacial defects, underscoring its critical role in establishing mandibular versus maxillary identity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In adults, dysregulation of EDNRA contributes to multiple vascular and organ dysfunctions. Increased EDNRA expression in glomerular endothelial cells has been linked to mitochondrial oxidative stress and diabetic kidney injury, while augmented receptor activity is observed in pulmonary vasculature in association with elevated pulmonary pressures."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, genetic variants affecting EDNRA function have been associated with intracranial aneurysm susceptibility and with migraine risk, reflecting its influence on vascular wall tone and remodeling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In oncology, EDNRA signaling is co‐opted to promote tumor aggressiveness. In both bladder and ovarian carcinomas, ET‐1 acting via EDNRA enhances cell proliferation, invasiveness, angiogenesis, and even chemoresistance through β‐arrestin–dependent pathways and interactions with the Wnt/β‐catenin axis. These mechanisms not only facilitate epithelial–mesenchymal transition but also disrupt gap junctional communication, thereby fostering a microenvironment conducive to metastatic dissemination."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "15"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, in the ocular system, EDNRA has been implicated in the modulation of trabecular meshwork contractility and intraocular pressure. MicroRNA‐mediated regulation of EDNRA activity (for example, by miR‐200c) alters cell contractility, suggesting that selective targeting of EDNRA may have therapeutic potential in glaucoma management."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight EDNRA as a central node in ET‐1–mediated signaling. Its actions govern diverse processes including vascular tone regulation, tissue remodeling, neural crest–derived craniofacial morphogenesis, and tumor progression. The broad functional spectrum of EDNRA underscores its potential as a promising therapeutic target across vascular, developmental, renal, cardiac, oncologic, and ocular disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xu Shi-Wen, Yunliang Chen, Christopher P Denton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e03-12-0902"}], "href": "https://doi.org/10.1091/mbc.e03-12-0902"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15047866"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15047866"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Angelika Horstmeyer, Christoph Licht, Gabriele Scherr, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Signalling and regulation of collagen I synthesis by ET-1 and TGF-beta1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1742-4658.2005.05016.x"}], "href": "https://doi.org/10.1111/j.1742-4658.2005.05016.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16336267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16336267"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "J Charité, D G McFadden, G Merlo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.931701"}], "href": "https://doi.org/10.1101/gad.931701"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11711438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11711438"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Louis-Bruno Ruest, Xilin Xiang, Kim-Chew Lim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.01291"}], "href": "https://doi.org/10.1242/dev.01291"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15306564"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15306564"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Takahiro Sato, Yukiko Kurihara, Rieko Asai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An endothelin-1 switch specifies maxillomandibular identity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0807345105"}], "href": "https://doi.org/10.1073/pnas.0807345105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19017795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19017795"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xu Shi-Wen, Fernando Rodríguez-Pascual, Santiago Lamas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00625-06"}], "href": "https://doi.org/10.1128/MCB.00625-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16809784"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16809784"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Haiying Qi, Gabriella Casalena, Shaolin Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db16-0695"}], "href": "https://doi.org/10.2337/db16-0695"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27899487"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27899487"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Vladimir I Bushuev, Galina Y Miasnikova, Adelina I Sergueeva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endothelin-1, vascular endothelial growth factor and systolic pulmonary artery pressure in patients with Chuvash polycythemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2006)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16769575"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16769575"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Matthew J Grimshaw, Julia L Wilson, Frances R Balkwill "}, {"type": "b", "children": [{"type": "t", "text": "Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1521-4141(200209)32:9"}, {"type": "a", "children": [{"type": "t", "text": "2393::AID-IMMU2393"}], "href": "2393::AID-IMMU2393"}, {"type": "t", "text": "3.0.CO;2-4"}], "href": "https://doi.org/10.1002/1521-4141(200209"}, {"type": "t", "text": "32:9"}, {"type": "a", "children": [{"type": "t", "text": "2393::AID-IMMU2393"}], "href": "2393::AID-IMMU2393"}, {"type": "t", "text": "3.0.CO;2-4) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12207323"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12207323"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Tatiana Foroud, Daniel L Koller, Dongbing Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stroke (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/STROKEAHA.112.656397"}], "href": "https://doi.org/10.1161/STROKEAHA.112.656397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22961961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22961961"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Siew-Kee Low, Atsushi Takahashi, Pei-Chieng Cha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/dds020"}], "href": "https://doi.org/10.1093/hmg/dds020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22286173"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22286173"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Neveen Said, Steven Smith, Marta Sanchez-Carbayo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor endothelin-1 enhances metastatic colonization of the lung in mouse xenograft models of bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI42912"}], "href": "https://doi.org/10.1172/JCI42912"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21183790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21183790"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Francesca Spinella, Laura Rosanò, Valeriana Di Castro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endothelin-1-induced prostaglandin E2-EP2, EP4 signaling regulates vascular endothelial growth factor production and ovarian carcinoma cell invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M408584200"}], "href": "https://doi.org/10.1074/jbc.M408584200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15347673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15347673"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Laura Rosanò, Roberta Cianfrocca, Piera Tocci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endothelin A receptor/β-arrestin signaling to the Wnt pathway renders ovarian cancer cells resistant to chemotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-13-3133"}], "href": "https://doi.org/10.1158/0008-5472.CAN-13-3133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25377471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25377471"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Francesca Spinella, Laura Rosanò, Valeriana Di Castro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M304785200"}], "href": "https://doi.org/10.1074/jbc.M304785200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12907686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12907686"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Coralia Luna, Guorong Li, Jianyong Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of trabecular meshwork cell contraction and intraocular pressure by miR-200c."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0051688"}], "href": "https://doi.org/10.1371/journal.pone.0051688"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23272142"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23272142"}]}]}]}
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Synonyms | ETA, HET-AR, ETAR, MFDA, ETA-R, ET-A, ETRA |
Proteins | EDNRA_HUMAN |
NCBI Gene ID | 1909 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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EDNRA has 9,409 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 121 datasets.
Click the + buttons to view associations for EDNRA from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of EDNRA gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of EDNRA gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of EDNRA gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of EDNRA gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of EDNRA gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
Biocarta Pathways | pathways involving EDNRA protein from the Biocarta Pathways dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of EDNRA gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of EDNRA gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of EDNRA gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of EDNRA gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CCLE Cell Line Gene Mutation Profiles | cell lines with EDNRA gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with EDNRA gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of EDNRA gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of EDNRA gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of EDNRA gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of EDNRA gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing EDNRA protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Experimental Protein Localization Evidence Scores | cellular components containing EDNRA protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing EDNRA protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with EDNRA protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with EDNRA protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of EDNRA gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with EDNRA gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with EDNRA gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with EDNRA gene/protein from the curated CTD Gene-Disease Associations dataset. | |
dbGAP Gene-Trait Associations | traits associated with EDNRA gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by EDNRA gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Curated Gene-Disease Association Evidence Scores 2025 | diseases involving EDNRA gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores | diseases associated with EDNRA gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with EDNRA gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with EDNRA gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with EDNRA gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with EDNRA gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with EDNRA gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
DrugBank Drug Targets | interacting drugs for EDNRA protein from the curated DrugBank Drug Targets dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at EDNRA gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of EDNRA gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of EDNRA gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing EDNRA from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with EDNRA gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GAD High Level Gene-Disease Associations | diseases associated with EDNRA gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of EDNRA gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with EDNRA gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing EDNRA from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of EDNRA gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of EDNRA gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of EDNRA gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of EDNRA gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of EDNRA gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of EDNRA gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GlyGen Glycosylated Proteins | ligands (chemical) binding EDNRA protein from the GlyGen Glycosylated Proteins dataset. | |
GO Biological Process Annotations 2015 | biological processes involving EDNRA gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving EDNRA gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving EDNRA gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing EDNRA protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by EDNRA gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by EDNRA gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by EDNRA gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx eQTL 2025 | SNPs regulating expression of EDNRA gene from the GTEx eQTL 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of EDNRA gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of EDNRA gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of EDNRA gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of EDNRA gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
Guide to Pharmacology Chemical Ligands of Receptors | ligands (chemical) binding EDNRA receptor from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. | |
Guide to Pharmacology Protein Ligands of Receptors | ligands (protein) binding EDNRA receptor from the curated Guide to Pharmacology Protein Ligands of Receptors dataset. | |
GWAS Catalog SNP-Phenotype Associations | phenotypes associated with EDNRA gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset. | |
GWASdb SNP-Disease Associations | diseases associated with EDNRA gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
GWASdb SNP-Phenotype Associations | phenotypes associated with EDNRA gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of EDNRA gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HMDB Metabolites of Enzymes | interacting metabolites for EDNRA protein from the curated HMDB Metabolites of Enzymes dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of EDNRA gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of EDNRA gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of EDNRA protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of EDNRA gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
HPO Gene-Disease Associations | phenotypes associated with EDNRA gene by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for EDNRA from the curated Hub Proteins Protein-Protein Interactions dataset. | |
HuBMAP ASCT+B Annotations | cell types associated with EDNRA gene from the HuBMAP ASCT+B dataset. | |
HuBMAP ASCT+B Augmented with RNA-seq Coexpression | cell types associated with EDNRA gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset. | |
HuBMAP Azimuth Cell Type Annotations | cell types associated with EDNRA gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with EDNRA gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by EDNRA gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for EDNRA protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of EDNRA gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
KEGG Pathways | pathways involving EDNRA protein from the KEGG Pathways dataset. | |
Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate EDNRA protein from the Kinase Library Serine Threonine Atlas dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of EDNRA gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of EDNRA gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of EDNRA gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of EDNRA gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of EDNRA gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain EDNRA protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by EDNRA gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting EDNRA gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of EDNRA gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of EDNRA gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by EDNRA gene mutations from the MPO Gene-Phenotype Associations dataset. | |
MSigDB Cancer Gene Co-expression Modules | co-expressed genes for EDNRA from the MSigDB Cancer Gene Co-expression Modules dataset. | |
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of EDNRA gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
OMIM Gene-Disease Associations | phenotypes associated with EDNRA gene from the curated OMIM Gene-Disease Associations dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for EDNRA from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of EDNRA gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of EDNRA gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving EDNRA protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving EDNRA protein from the Wikipathways PFOCR 2024 dataset. | |
PID Pathways | pathways involving EDNRA protein from the PID Pathways dataset. | |
Reactome Pathways 2014 | pathways involving EDNRA protein from the Reactome Pathways dataset. | |
Reactome Pathways 2024 | pathways involving EDNRA protein from the Reactome Pathways 2024 dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of EDNRA gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at EDNRA gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of EDNRA gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of EDNRA gene from the RummaGEO Gene Perturbation Signatures dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of EDNRA gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of EDNRA gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of EDNRA gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of EDNRA protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of EDNRA protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of EDNRA protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with EDNRA protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with EDNRA protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
WikiPathways Pathways 2014 | pathways involving EDNRA protein from the Wikipathways Pathways 2014 dataset. | |
WikiPathways Pathways 2024 | pathways involving EDNRA protein from the WikiPathways Pathways 2024 dataset. | |