{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n EEF1D, the δ‐subunit of the eukaryotic translation elongation factor 1 complex, is best known for its canonical role in delivering aminoacyl‐tRNAs to the ribosome during protein synthesis. In addition to this central function, multiple studies indicate that EEF1D is “moonlighting” in diverse regulatory pathways. Its aberrant expression has been linked to tumorigenesis: increased levels correlate with poor clinical outcome in medulloblastoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and contribute to the promotion of cell proliferation, cyclin D1 activation, and epithelial‐to‐mesenchymal transition in oral squamous cell carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, upregulation of EEF1D accompanies cadmium‐induced malignant transformation in bronchial epithelial cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In the context of host–virus interactions, EEF1D is targeted by viral kinases during herpes simplex virus type 1 infection, resulting in hyperphosphorylation that may modulate its translational activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, EEF1D engages in protein–protein interactions that extend its functional repertoire; for instance, it physically associates with SIAH‐1 and inhibits SIAH‐1 auto‐ubiquitination, thereby affecting protein stability networks"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", and it interacts with the translationally controlled tumor protein (TCTP), suggesting a role in coordinating protein synthesis within cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Genetic studies further implicate EEF1D in neuronal function, as mutations in this gene have been associated with neurodevelopmental disorders"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", with additional evidence from a consanguineous family linking loss‐of‐function variants of the long EEF1D isoform to intellectual disability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Finally, expression correlation analyses have identified that EEF1D is co‐regulated with other members of the EEF1 complex in various cancers, underscoring its potential contribution to oncogenic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Massimiliano De Bortoli, Robert C Castellino, Xin-Yan Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-6-223"}], "href": "https://doi.org/10.1186/1471-2407-6-223"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16968546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16968546"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Isadora L Flores, Rebeca Kawahara, Márcia C C Miguel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EEF1D modulates proliferation and epithelial-mesenchymal transition in oral squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Sci (Lond) (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/CS20150646"}], "href": "https://doi.org/10.1042/CS20150646"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26823560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26823560"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yi-Xiong Lei, Min Wang, Lian Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alternative expression and sequence of human elongation factor-1 delta during malignant transformation of human bronchial epithelial cells induced by cadmium chloride."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Environ Sci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0895-3988(10)60045-1"}], "href": "https://doi.org/10.1016/s0895-3988(10"}, {"type": "t", "text": "60045-1) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20514991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20514991"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Y Kawaguchi, C Van Sant, B Roizman "}, {"type": "b", "children": [{"type": "t", "text": "Eukaryotic elongation factor 1delta is hyperphosphorylated by the protein kinase encoded by the U(L)13 gene of herpes simplex virus 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (1998)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.72.3.1731-1736.1998"}], "href": "https://doi.org/10.1128/JVI.72.3.1731-1736.1998"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "9499021"}], "href": "https://pubmed.ncbi.nlm.nih.gov/9499021"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Huiling Wu, Yan Shi, Ying Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Eukaryotic translation elongation factor 1 delta inhibits the ubiquitin ligase activity of SIAH-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-011-0891-5"}], "href": "https://doi.org/10.1007/s11010-011-0891-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21633900"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21633900"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jacqueline M Langdon, Becky M Vonakis, Susan M MacDonald "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the interaction between the human recombinant histamine releasing factor/translationally controlled tumor protein and elongation factor-1 delta (also known as eElongation factor-1B beta)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2003.12.007"}], "href": "https://doi.org/10.1016/j.bbadis.2003.12.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15062873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15062873"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Fiona McLachlan, Anna Martinez Sires, Catherine M Abbott "}, {"type": "b", "children": [{"type": "t", "text": "The role of translation elongation factor eEF1 subunits in neurodevelopmental disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.23677"}], "href": "https://doi.org/10.1002/humu.23677"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30370994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30370994"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sibel Aylin Ugur Iseri, Emrah Yucesan, Feyza Nur Tuncer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biallelic loss of EEF1D function links heat shock response pathway to autosomal recessive intellectual disability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s10038-019-0570-z"}], "href": "https://doi.org/10.1038/s10038-019-0570-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30787422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30787422"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Burcu Biterge Süt "}, {"type": "b", "children": [{"type": "t", "text": "Data article on genes that share similar expression patterns with EEF1 complex proteins in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Data Brief (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dib.2020.105162"}], "href": "https://doi.org/10.1016/j.dib.2020.105162"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32025546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32025546"}]}]}]}