{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n EFCAB8 has emerged as a gene of interest in diverse studies even though its function is not the primary focus in each report. In one study investigating the genetic causes of acephalic spermatozoa syndrome, a large deletion encompassing complete SUN5 together with partial EFCAB8 was identified. While the phenotype was mainly attributed to SUN5 disruption, the involvement of EFCAB8 in this deletion hints that alterations in its integrity may co‐occur in the complex genetic rearrangements associated with abnormal sperm morphology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In another investigation into oxaliplatin‐induced peripheral neuropathy, transcriptomic analysis revealed that EFCAB8 was among several genes that were transcriptionally turned off after chemotherapy, suggesting that a loss or suppression of EFCAB8 expression might be linked to the onset of neuropathic side effects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Additionally, genome‐wide association analyses in Nellore cattle demonstrated that variation near the EFCAB8 locus was associated with carcass traits such as hot carcass weight, implying a potential role for EFCAB8 in processes that influence growth or metabolic characteristics in livestock."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Together, these findings suggest that EFCAB8, likely encoding a protein with calcium‐binding domains, may play context‐dependent roles in reproductive biology, neural response to chemotherapeutic stress, and metabolic or developmental pathways that affect economically important traits.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mingfei Xiang, Yu Wang, Ke Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel Mutation and Deletion in SUN5 Cause Male Infertility with Acephalic Spermatozoa Syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s43032-021-00665-5"}], "href": "https://doi.org/10.1007/s43032-021-00665-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34159570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34159570"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Manuel Morales, Julio Ávila, Rebeca González-Fernández, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential transcriptome profile of peripheral white cells to identify biomarkers involved in oxaliplatin induced neuropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pers Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/jpm4020282"}], "href": "https://doi.org/10.3390/jpm4020282"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25563226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25563226"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "R Espigolan, F Baldi, A A Boligon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Associations between single nucleotide polymorphisms and carcass traits in Nellore cattle using high-density panels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Mol Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4238/2015.September.22.7"}], "href": "https://doi.org/10.4238/2015.September.22.7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26400344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26400344"}]}]}]}