EGFL7 Gene

Name	EGF-like-domain, multiple 7
Description	This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Epidermal growth factor‐like domain 7 (EGFL7) is a secreted protein predominantly expressed by activated endothelial cells that plays multifaceted roles during vascular development and remodeling. EGFL7 is released into the extracellular space where it modulates the spatial organization and collective migration of endothelial cells during tubulogenesis, acting in part as a chemoattractant and guiding cell–cell interactions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, EGFL7 is unique among angiogenic factors because its expression is almost exclusively restricted to the endothelium, and it influences vessel patterning and integrity by interfacing with extracellular matrix components and integrin receptors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In addition, EGFL7 can directly interact with Notch receptors, thereby antagonizing Notch signaling and modulating cell differentiation and proliferation in both neural stem cells and vascular endothelial cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Beyond its developmental roles, EGFL7 (also known as VE‐statin) acts as an inhibitor of smooth muscle cell migration and suppresses vascular elastogenesis through interactions with lysyl oxidases, indicating a regulatory function in vessel stabilization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Aberrant expression of EGFL7 is also observed in several cancers, where it contributes to tumor progression. In hepatocellular carcinoma, for example, elevated EGFL7 levels promote metastasis by enhancing cell motility via epidermal growth factor receptor–dependent focal adhesion kinase activation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", while in breast and lung carcinomas, EGFL7 expression in tumor cells is associated with diminished endothelial adhesion molecule expression, reduced immune cell infiltration, and accelerated tumor dissemination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Similarly, in gastric cancer, overexpression of EGFL7 facilitates epithelial–mesenchymal transition through activation of the EGFR–AKT–Snail signaling pathway, thereby enhancing invasive and migratory capacities"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", and in malignant gliomas, EGFL7 upregulation correlates with increased tumor grade, proliferation, and angiogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Notably, the genomic locus encoding EGFL7 also harbors microRNA‐126, which is coexpressed with its host gene and contributes to the regulation of vascular integrity and angiogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " In addition, regulatory mechanisms involving long noncoding RNAs, such as MALAT1, have been shown to modulate EGFL7 expression via epigenetic modifications, linking its deregulation to enhanced invasion and metastasis in cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, EGFL7 serves as a key extracellular regulator in both physiological vasculogenesis and pathological angiogenesis. It orchestrates endothelial cell behavior through modulation of the extracellular matrix, integrin and Notch signaling, and by influencing smooth muscle cell dynamics, while its dysregulation in tumor cells promotes metastasis and immune evasion.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Leon H Parker, Maike Schmidt, Suk-Won Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature02416"}], "href": "https://doi.org/10.1038/nature02416"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15085134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15085134"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Maike Schmidt, Kim Paes, Ann De Mazière, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.002576"}], "href": "https://doi.org/10.1242/dev.002576"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17626061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17626061"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Donna Nichol, Heidi Stuhlmann "}, {"type": "b", "children": [{"type": "t", "text": "EGFL7: a unique angiogenic signaling factor in vascular development and disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-10-322446"}], "href": "https://doi.org/10.1182/blood-2011-10-322446"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22160377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22160377"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mirko H H Schmidt, Frank Bicker, Iva Nikolic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1896"}], "href": "https://doi.org/10.1038/ncb1896"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19503073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19503073"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Fabrice Soncin, Virginie Mattot, Frédéric Lionneton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VE-statin, an endothelial repressor of smooth muscle cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/emboj/cdg549"}], "href": "https://doi.org/10.1093/emboj/cdg549"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14592969"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14592969"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Etienne Lelièvre, Aleksander Hinek, Florea Lupu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VE-statin/egfl7 regulates vascular elastogenesis by interacting with lysyl oxidases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2008.103"}], "href": "https://doi.org/10.1038/emboj.2008.103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18497746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18497746"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Fan Wu, Lian-Yue Yang, Yun-Feng Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel role for epidermal growth factor-like domain 7 in metastasis of human hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.23197"}], "href": "https://doi.org/10.1002/hep.23197"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19824075"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19824075"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Suzanne Delfortrie, Sébastien Pinte, Virginie Mattot, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Egfl7 promotes tumor escape from immunity by repressing endothelial cell activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-11-1301"}], "href": "https://doi.org/10.1158/0008-5472.CAN-11-1301"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22037871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22037871"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Bai-Hua Luo, Feng Xiong, Jun-Pu Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epidermal growth factor-like domain-containing protein 7 (EGFL7) enhances EGF receptor-AKT signaling, epithelial-mesenchymal transition, and metastasis of gastric cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0099922"}], "href": "https://doi.org/10.1371/journal.pone.0099922"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24945379"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24945379"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Chun-hai Huang, Xue-jun Li, Yi-zeng Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and clinical significance of EGFL7 in malignant glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-010-0832-9"}], "href": "https://doi.org/10.1007/s00432-010-0832-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20213100"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20213100"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Frank Kuhnert, Michael R Mancuso, Jessica Hampton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.029736"}], "href": "https://doi.org/10.1242/dev.029736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18987025"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18987025"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Quan-Jun Deng, Li-Qun Xie, Hua Li "}, {"type": "b", "children": [{"type": "t", "text": "Overexpressed MALAT1 promotes invasion and metastasis of gastric cancer cells via increasing EGFL7 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2016.05.041"}], "href": "https://doi.org/10.1016/j.lfs.2016.05.041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27259812"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27259812"}]}]}]}
Synonyms	VE-STATIN, NEU1, ZNEU1
Proteins	EGFL7_HUMAN
NCBI Gene ID	51162
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

EGFL7 has 7,654 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.

Click the + buttons to view associations for EGFL7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

EGFL7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by EGFL7 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of EGFL7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of EGFL7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of EGFL7 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of EGFL7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of EGFL7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of EGFL7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of EGFL7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of EGFL7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of EGFL7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of EGFL7 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of EGFL7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of EGFL7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with EGFL7 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with EGFL7 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of EGFL7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of EGFL7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of EGFL7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with EGFL7 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of EGFL7 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of EGFL7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing EGFL7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing EGFL7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with EGFL7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with EGFL7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of EGFL7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with EGFL7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with EGFL7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of EGFL7 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by EGFL7 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for EGFL7 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with EGFL7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with EGFL7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with EGFL7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with EGFL7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at EGFL7 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of EGFL7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of EGFL7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing EGFL7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with EGFL7 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.