EI24 Gene

Name	etoposide induced 2.4
Description	This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n EI24 (etoposide‐induced protein 2.4), a p53‐responsive gene, has emerged as a multifunctional regulator that links cell death, autophagy, and protein homeostasis with tumor suppression. Multiple studies have shown that EI24 is essential for maintaining basal autophagic flux by promoting the maturation of autophagosomes into autolysosomes, thereby preventing the accumulation of deleterious protein aggregates and ensuring cellular proteostasis—a function that is critical in neural, hepatic, and secretory cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of cancer, EI24 acts as a tumor suppressor by inhibiting several malignant phenotypes. Its downregulation, often driven by oncogenic microRNAs (such as miR‐455–3p and miR‐483–3p), has been linked to enhanced cell proliferation, invasion, epithelial–mesenchymal transition, and drug resistance in various tumor types including triple‐negative breast cancer, cervical carcinoma, colorectal cancer, and non‐small cell lung cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "5"}]}, {"type": "t", "text": " Restoration of EI24 expression or its functions often reverts these aggressive traits, underscoring its potential as a prognostic marker and therapeutic target.\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in autophagy and apoptosis, EI24 contributes to the crosstalk between the ubiquitin–proteasome system and autophagy by mediating the lysosome‐dependent degradation of specific RING E3 ubiquitin ligases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In addition, EI24 can interact with nuclear transport proteins—such as importin β1 and importin α2—to inhibit proper nuclear import, thereby influencing the localization and activity of key regulatory factors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in non‐tumor contexts, overexpression of EI24 has been shown to alleviate pathological signaling—such as NF‑κB activation via the targeted degradation of TRAF2—and to protect against fibrosis in organs like the kidney."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Collectively, these findings highlight EI24 as a central node that integrates stress signaling, inflammation, and proteolysis to maintain cellular homeostasis and suppress tumor progression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yan G Zhao, Hongyu Zhao, Lin Miao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The p53-induced gene Ei24 is an essential component of the basal autophagy pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.415968"}], "href": "https://doi.org/10.1074/jbc.M112.415968"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23074225"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23074225"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jung-Min Choi, Sushil Devkota, Young Hoon Sung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-κB activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.1434"}], "href": "https://doi.org/10.18632/oncotarget.1434"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24280371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24280371"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhishuang Li, Qingyong Meng, Aifeng Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-455-3p promotes invasion and migration in triple negative breast cancer by targeting tumor suppressor EI24."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.14307"}], "href": "https://doi.org/10.18632/oncotarget.14307"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28038450"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28038450"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jung-Min Choi, Ji-Young Jang, Yu-Ra Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced expression of EI24 confers resistance to gefitinib through IGF-1R signaling in PC9 NSCLC cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lung Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lungcan.2015.08.019"}], "href": "https://doi.org/10.1016/j.lungcan.2015.08.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26342551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26342551"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Wei Zhou, Wanli Yang, Jing Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR‑483 promotes the development of colorectal cancer by inhibiting the expression level of EI24."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2021.12206"}], "href": "https://doi.org/10.3892/mmr.2021.12206"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34109432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34109432"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sushil Devkota, Hyobin Jeong, Yunmi Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional characterization of EI24-induced autophagy in the degradation of RING-domain E3 ligases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2016.1217371"}], "href": "https://doi.org/10.1080/15548627.2016.1217371"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27541728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27541728"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Kim G Lieu, Eun-Hee Shim, Jinling Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The p53-induced factor Ei24 inhibits nuclear import through an importin β-binding-like domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201304055"}], "href": "https://doi.org/10.1083/jcb.201304055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24821838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24821838"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Feng Zhao, Menglin Yuan, Liying Lei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced production of mono-rhamnolipid in Pseudomonas aeruginosa and application potential in agriculture and petroleum industry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioresour Technol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biortech.2020.124605"}], "href": "https://doi.org/10.1016/j.biortech.2020.124605"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33388600"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33388600"}]}]}]}
Synonyms	TP53I8, PIG8, EPG4
Proteins	EI24_HUMAN
NCBI Gene ID	9538
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

EI24 has 6,465 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 113 datasets.

Click the + buttons to view associations for EI24 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

EI24 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of EI24 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of EI24 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of EI24 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of EI24 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of EI24 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of EI24 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of EI24 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of EI24 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of EI24 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of EI24 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of EI24 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of EI24 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with EI24 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with EI24 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of EI24 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of EI24 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of EI24 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing EI24 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of EI24 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing EI24 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing EI24 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing EI24 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with EI24 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with EI24 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of EI24 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with EI24 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with EI24 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of EI24 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with EI24 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with EI24 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with EI24 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with EI24 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at EI24 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of EI24 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of EI24 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing EI24 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of EI24 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with EI24 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing EI24 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of EI24 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.