EIF3D Gene

Name	eukaryotic translation initiation factor 3, subunit D
Description	Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n EIF3D, a subunit of the eukaryotic initiation factor 3 (eIF3) complex, has emerged as a multifunctional protein with diverse roles in mRNA translation and cellular regulation. Structural and biochemical studies have revealed that EIF3D directly binds the 5′ cap of mRNAs, thereby mediating an alternative form of cap‐dependent translation initiation that operates independently of the classical eIF4E pathway. This specialized mechanism ensures efficient translation of a subset of mRNAs—often those involved in cell proliferation and stress responses—even when canonical translation is compromised."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its central role in translation initiation, EIF3D has been implicated in oncogenesis across multiple cancer types. Aberrant overexpression of EIF3D contributes to enhanced cell proliferation, invasion, and resistance to apoptosis in malignancies such as gallbladder"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", renal cell"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", breast"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", melanoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", cervix"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", hepatocellular carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "and acute myeloid leukemia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " In these contexts, EIF3D not only facilitates translation but also exerts non‐canonical functions—for example, by stabilizing key regulatory proteins such as GRK2 and GRP78—to activate oncogenic signaling cascades (e.g., the PI3K/Akt pathway)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "6"}, {"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Moreover, translational regulation of specific splicing factors through an EIF3D‐dependent mechanism further underscores its broad impact on gene expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n EIF3D also contributes to viral and immune functions. It has been identified as a proviral host factor that facilitates efficient replication of viral RNAs"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", and its expression in CD8+ T cells is critical for maintaining proper immune responses; reduced EIF3D levels compromise T cell proliferation and cytokine production, thereby favoring viral infection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " In mesothelioma cells, EIF3D is among several anti‐apoptotic factors required to sustain cell viability"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": ", further highlighting its role in cell survival.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings establish EIF3D as a critical mediator of both canonical translation initiation—as a direct cap‐binding and 40S–ribosome bridging factor"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "—and as a multifunctional regulator of oncogenic and immune processes in diverse cellular contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "7"}, {"type": "fg_f", "ref": "10"}, {"type": "fg_f", "ref": "16"}, {"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Consequently, EIF3D represents an attractive target for therapeutic intervention in cancer and viral diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Amy S Lee, Philip J Kranzusch, Jennifer A Doudna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature18954"}], "href": "https://doi.org/10.1038/nature18954"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27462815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27462815"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Columba de la Parra, Amanda Ernlund, Amandine Alard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A widespread alternate form of cap-dependent mRNA translation initiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-05539-0"}], "href": "https://doi.org/10.1038/s41467-018-05539-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30076308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30076308"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Anna Herrmannová, Terezie Prilepskaja, Susan Wagner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkz1185"}], "href": "https://doi.org/10.1093/nar/gkz1185"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31863585"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31863585"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Fei Zhang, Shanshan Xiang, Yang Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EIF3D promotes gallbladder cancer development by stabilizing GRK2 kinase and activating PI3K-AKT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2017.263"}], "href": "https://doi.org/10.1038/cddis.2017.263"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28594409"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28594409"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiu-Wu Pan, Lu Chen, Yi Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EIF3D silencing suppresses renal cell carcinoma tumorigenesis via inducing G2/M arrest through downregulation of Cyclin B1/CDK1 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2016.3459"}], "href": "https://doi.org/10.3892/ijo.2016.3459"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27035563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27035563"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hai Huang, Yi Gao, Ao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EIF3D promotes sunitinib resistance of renal cell carcinoma by interacting with GRP78 and inhibiting its degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2019.10.030"}], "href": "https://doi.org/10.1016/j.ebiom.2019.10.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31669222"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31669222"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yan Fan, Yufei Guo "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of eIF3D inhibits breast cancer cell proliferation and invasion through suppressing the Wnt/β-catenin signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26617750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26617750"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hui Li, Fusheng Zhou, Hongyan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of EIF3D suppresses proliferation of human melanoma cells through G2/M phase arrest."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biotechnol Appl Biochem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/bab.1305"}], "href": "https://doi.org/10.1002/bab.1305"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25322666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25322666"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yan Zhong, Jian Lan "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of Eukaryotic translation initiation factor 3D induces stem cell-like properties and metastasis in cervix cancer by activating FAK through inhibiting degradation of GRP78."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2024336"}], "href": "https://doi.org/10.1080/21655979.2021.2024336"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35104170"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35104170"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Masashi Maekawa, Hiromi Hiyoshi, Jun Nakayama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cullin-3/KCTD10 complex is essential for K27-polyubiquitination of EIF3D in human hepatocellular carcinoma HepG2 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.07.010"}], "href": "https://doi.org/10.1016/j.bbrc.2019.07.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31280863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31280863"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Guo-Zhen Liu, Ji-Zhu Liu, Xiao-Qing Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-017-3127-5"}], "href": "https://doi.org/10.1007/s11010-017-3127-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28801778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28801778"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Maciej Cieśla, Phuong Cao Thi Ngoc, Eugenia Cordero, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2021.01.034"}], "href": "https://doi.org/10.1016/j.molcel.2021.01.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33662273"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33662273"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Sungyul Lee, Young-Suk Lee, Yeon Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The SARS-CoV-2 RNA interactome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2021.04.022"}], "href": "https://doi.org/10.1016/j.molcel.2021.04.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33989516"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33989516"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ying Pan, Zi-Ning Zhang, Lin-Bo Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced eIF3d accelerates HIV disease progression by attenuating CD8+ T cell function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-019-1925-0"}], "href": "https://doi.org/10.1186/s12967-019-1925-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31118081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31118081"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Fernando Valiente-Echeverría, Luca Melnychuk, Kishanda Vyboh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "eEF2 and Ras-GAP SH3 domain-binding protein (G3BP1) modulate stress granule assembly during HIV-1 infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms5819"}], "href": "https://doi.org/10.1038/ncomms5819"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25229650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25229650"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Wenfeng Du, Honggang Cheng, Lipan Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hmiR-34c-3p upregulation inhibits the proliferation of colon cancer cells by targeting EIF3D."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Drugs (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CAD.0000000000000674"}], "href": "https://doi.org/10.1097/CAD.0000000000000674"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30096129"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30096129"}]}]}]}
Synonyms	EIF3S7, EIF3-ZETA, EIF3-P66
Proteins	EIF3D_HUMAN
NCBI Gene ID	8664
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

EIF3D has 8,124 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 114 datasets.

Click the + buttons to view associations for EIF3D from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

EIF3D Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of EIF3D gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of EIF3D gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of EIF3D gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of EIF3D gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of EIF3D gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of EIF3D gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of EIF3D gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of EIF3D gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of EIF3D gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of EIF3D gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of EIF3D gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of EIF3D gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with EIF3D protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of EIF3D gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of EIF3D gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of EIF3D gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing EIF3D protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing EIF3D protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing EIF3D protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing EIF3D protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with EIF3D protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing EIF3D protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of EIF3D gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with EIF3D gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with EIF3D gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with EIF3D gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with EIF3D gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with EIF3D gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at EIF3D gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of EIF3D gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of EIF3D gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing EIF3D from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with EIF3D gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of EIF3D gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with EIF3D gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing EIF3D from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of EIF3D gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of EIF3D gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of EIF3D gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of EIF3D gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.