EIF3E Gene

Name	eukaryotic translation initiation factor 3, subunit E
Description	Enables RNA binding activity and cadherin binding activity. Contributes to translation initiation factor activity. Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; positive regulation of translation; and translational initiation. Located in PML body and cytosol. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n EIF3E (also known as Int6) is a multifunctional subunit of the eukaryotic translation initiation factor 3 (eIF3) complex that plays several critical roles in translation and mRNA metabolism. As a non‐conserved component of the functional core of eIF3, EIF3E facilitates the recruitment of the 40S ribosomal subunit to mRNA and contributes to cap‐dependent translation initiation through its direct interaction with eIF4G, which in turn promotes phosphorylation of the cap binding protein eIF4E via recruitment of Mnk1."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, EIF3E is implicated in mRNA quality control; its interaction with factors such as CBP80 and UPF2 links the translation initiation machinery to the nonsense-mediated mRNA decay (NMD) pathway, ensuring the efficient elimination of aberrant transcripts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Aberrant expression or structural alteration of EIF3E has been associated with tumorigenesis. Expression of a truncated form of EIF3E can induce malignant transformation and render cells more resistant to apoptotic signals"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", while reduced levels of EIF3E have been linked to the induction of epithelial-to-mesenchymal transition in breast epithelial cells, thereby promoting invasion and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, in models of glioblastoma, suppression of EIF3E leads to decreased proliferation and increased apoptosis, in part through modulation of hypoxia-inducible factor levels."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In sum, these studies collectively reveal that EIF3E acts as a key regulator at the crossroads of translation initiation, mRNA surveillance, and oncogenic signaling. Its ability to coordinate the assembly and function of the translation initiation complex and to interface with mRNA decay pathways underscores its importance not only in normal cellular protein synthesis but also in the dysregulation of these processes during tumor development.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mamiko Masutani, Nahum Sonenberg, Shigeyuki Yokoyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reconstitution reveals the functional core of mammalian eIF3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601765"}], "href": "https://doi.org/10.1038/sj.emboj.7601765"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17581632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17581632"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Aaron K LeFebvre, Nadejda L Korneeva, Marjan Trutschl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M605418200"}], "href": "https://doi.org/10.1074/jbc.M605418200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16766523"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16766523"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Derek Walsh, Ian Mohr "}, {"type": "b", "children": [{"type": "t", "text": "Coupling 40S ribosome recruitment to modification of a cap-binding initiation factor by eIF3 subunit e."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.236752.113"}], "href": "https://doi.org/10.1101/gad.236752.113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24736843"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24736843"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Vincent Mocquet, Julia Neusiedler, Francesca Rende, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.07021-11"}], "href": "https://doi.org/10.1128/JVI.07021-11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22553336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22553336"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Christelle Morris, Jürgen Wittmann, Hans-Martin Jäck, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human INT6/eIF3e is required for nonsense-mediated mRNA decay."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.embor.7400955"}], "href": "https://doi.org/10.1038/sj.embor.7400955"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17468741"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17468741"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Greg L Mayeur, John W B Hershey "}, {"type": "b", "children": [{"type": "t", "text": "Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0014-5793(02)02307-4"}], "href": "https://doi.org/10.1016/s0014-5793(02"}, {"type": "t", "text": "02307-4) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11904180"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11904180"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "L D Gillis, S M Lewis "}, {"type": "b", "children": [{"type": "t", "text": "Decreased eIF3e/Int6 expression causes epithelial-to-mesenchymal transition in breast epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.371"}], "href": "https://doi.org/10.1038/onc.2012.371"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22907435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22907435"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Julie Sesen, Anne Cammas, Sarah J Scotland, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Int6/eIF3e is essential for proliferation and survival of human glioblastoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms15022172"}], "href": "https://doi.org/10.3390/ijms15022172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24481065"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24481065"}]}]}]}
Synonyms	EIF3-P46, INT6, EIF3S6, EIF3-P48
Proteins	EIF3E_HUMAN
NCBI Gene ID	3646
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

EIF3E has 9,335 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 125 datasets.

Click the + buttons to view associations for EIF3E from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

EIF3E Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by EIF3E gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of EIF3E gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of EIF3E gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of EIF3E gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of EIF3E gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of EIF3E gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of EIF3E gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of EIF3E gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of EIF3E gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of EIF3E gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of EIF3E gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of EIF3E gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of EIF3E gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with EIF3E protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with EIF3E gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of EIF3E gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of EIF3E gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of EIF3E gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing EIF3E protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing EIF3E protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing EIF3E protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing EIF3E protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with EIF3E protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with EIF3E protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing EIF3E protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of EIF3E gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with EIF3E gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with EIF3E gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with EIF3E gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with EIF3E gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with EIF3E gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with EIF3E gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with EIF3E gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with EIF3E gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with EIF3E gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with EIF3E gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at EIF3E gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of EIF3E gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of EIF3E gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing EIF3E from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.