ELAVL1 Gene

HGNC Family	RNA binding motif containing (RBM)
Name	ELAV like RNA binding protein 1
Description	The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ELAVL1 (also known as HuR) is a ubiquitously expressed RNA‐binding protein that plays a central role in post‐transcriptional gene regulation. It primarily recognizes AU‐rich elements within the 3′ untranslated regions of its target mRNAs to enhance their stability and modulate translation, thereby influencing diverse cellular processes such as stress response, cell proliferation, and differentiation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " In response to cellular stress, HuR can bind to key transcripts such as those encoding SIRT1 and p53—stabilizing them and enhancing translation—as seen after oxidative challenges and UV‐irradiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Its actions extend to modulating oncogene expression; for example, HuR participates in recruiting components of the microRNA machinery (e.g. let-7) to repress targets such as c-Myc"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", and it is itself subject to microRNA-mediated downregulation in settings of inflammation (as with miR-146 in endothelial cells, thereby influencing inflammatory signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additionally, HuR functions as a scaffold that directs the subcellular localization of nascent proteins by bridging mRNAs with specific regulatory complexes; a notable example is its role in promoting the cell surface expression of membrane proteins through 3′ UTR-dependent mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Emerging studies have also revealed that HuR interfaces with epitranscriptomic modifications: m6A methylation can alter HuR binding to target pre-mRNAs, thereby impacting processes such as alternative splicing and mRNA stability in cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In liver fibrosis, for instance, HuR upregulation enhances the stability of mRNAs that promote autophagic flux, thus facilitating ferroptosis—a regulated form of cell death."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, interactions between HuR and long noncoding RNAs add an extra layer of regulation in oncogenesis. One study demonstrated that the nuclear lncRNA LINC00336 binds HuR, with the ensuing complex modulating ferroptosis, while HuR in turn stabilizes LINC00336 transcripts to support tumorigenic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Collectively, these reports highlight a multifaceted role for ELAVL1/HuR in orchestrating mRNA fate—from splicing and stability to translation and localization—thereby impacting cell survival, stress adaptation, inflammation, and tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "6"}, {"type": "fg_f", "ref": "9"}, {"type": "fg_f", "ref": "12"}, {"type": "fg_f", "ref": "8"}, {"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Svetlana Lebedeva, Marvin Jens, Kathrin Theil, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2011.06.008"}], "href": "https://doi.org/10.1016/j.molcel.2011.06.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21723171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21723171"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Neelanjan Mukherjee, David L Corcoran, Jeffrey D Nusbaum, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2011.06.007"}], "href": "https://doi.org/10.1016/j.molcel.2011.06.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21723170"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21723170"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Isabel López de Silanes, Ming Zhan, Ashish Lal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a target RNA motif for RNA-binding protein HuR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0306453101"}], "href": "https://doi.org/10.1073/pnas.0306453101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14981256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14981256"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ashish Lal, Krystyna Mazan-Mamczarz, Tomoko Kawai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7600305"}], "href": "https://doi.org/10.1038/sj.emboj.7600305"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15257295"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15257295"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kotb Abdelmohsen, Rudolf Pullmann, Ashish Lal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of HuR by Chk2 regulates SIRT1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2007.01.011"}], "href": "https://doi.org/10.1016/j.molcel.2007.01.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17317627"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17317627"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Krystyna Mazan-Mamczarz, Stefanie Galbán, Isabel López de Silanes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1432104100"}], "href": "https://doi.org/10.1073/pnas.1432104100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12821781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12821781"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hyeon Ho Kim, Yuki Kuwano, Subramanya Srikantan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HuR recruits let-7/RISC to repress c-Myc expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1812509"}], "href": "https://doi.org/10.1101/gad.1812509"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19574298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19574298"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Henry S Cheng, Nirojini Sivachandran, Andrew Lau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/emmm.201202318"}], "href": "https://doi.org/10.1002/emmm.201202318"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23733368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23733368"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Binyamin D Berkovits, Christine Mayr "}, {"type": "b", "children": [{"type": "t", "text": "Alternative 3' UTRs act as scaffolds to regulate membrane protein localization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature14321"}], "href": "https://doi.org/10.1038/nature14321"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25896326"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25896326"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yunhao Chen, Chuanhui Peng, Junru Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-019-1053-8"}], "href": "https://doi.org/10.1186/s12943-019-1053-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31438961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31438961"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Tian Lan, Hui Li, Delin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-019-1106-z"}], "href": "https://doi.org/10.1186/s12943-019-1106-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31856849"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31856849"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Zili Zhang, Zhen Yao, Ling Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2018.1503146"}], "href": "https://doi.org/10.1080/15548627.2018.1503146"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30081711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30081711"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yuanchao Xue, Kunfu Ouyang, Jie Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2012.11.045"}], "href": "https://doi.org/10.1016/j.cell.2012.11.045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23313552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23313552"}]}]}]}
Synonyms	ELAV1, HUA, HUR, MELG
Proteins	ELAV1_HUMAN
NCBI Gene ID	1994
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ELAVL1 has 15,145 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 123 datasets.

Click the + buttons to view associations for ELAVL1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ELAVL1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by ELAVL1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ELAVL1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ELAVL1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ELAVL1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ELAVL1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ELAVL1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ELAVL1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ELAVL1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ELAVL1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ELAVL1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ELAVL1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ELAVL1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ELAVL1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with ELAVL1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ELAVL1 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ELAVL1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ELAVL1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ELAVL1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ELAVL1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ELAVL1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ELAVL1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ELAVL1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ELAVL1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ELAVL1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ELAVL1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ELAVL1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ELAVL1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ELAVL1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ELAVL1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ELAVL1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ELAVL1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ELAVL1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ELAVL1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ELAVL1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ELAVL1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ELAVL1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ELAVL1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with ELAVL1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ELAVL1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with ELAVL1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.