ENDOD1 Gene

Name	endonuclease domain containing 1
Description	Predicted to enable endonuclease activity; metal ion binding activity; and nucleic acid binding activity. Predicted to be involved in innate immune response. Located in extracellular exosome and membrane. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ENDOD1, which encodes a protein containing an endonuclease domain, has emerged in diverse biological contexts that implicate it in both tumor biology and immune regulation. In studies on antidepressant response, differential basal expression of ENDOD1 was observed in lymphoblastoid cell lines with varying sensitivity to selective serotonin reuptake inhibitors, suggesting a potential link to mechanisms regulating synaptogenesis and neuronal circuitry."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In pancreatic ductal adenocarcinoma, ENDOD1 was identified as a predicted target of miR-148a‐3p, with its high expression correlating with poor prognosis, thereby suggesting that aberrant ENDOD1 levels may contribute to tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Increased expression of ENDOD1 in the cerebral cortex following acute injury in an interleukin‐6–driven neuroinflammatory model further supports a role in the response to tissue damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, ENDOD1 functions as part of a multiprotein complex with the ER‐resident E3 ubiquitin ligase RNF26—interacting with TMEM43, TMEM33, and TMED1—to modulate innate immune signaling via the cGAS–STING pathway, thus contributing to antiviral responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In an immunological context, analyses in red deer challenged with Mycobacterium avium subsp. paratuberculosis revealed upregulation of ENDOD1 in susceptible animals, where it was associated with antigen presentation and gut immune pathology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Differential expression of ENDOD1 has also been observed in soft tissue tumors, where it is part of a gene panel linked to alterations in cell–cell and cell–extracellular matrix interactions that may underlie aggressive tumor behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Finally, in studies of Japanese flounder immunity, ENDOD1 mRNA was markedly induced after bacterial challenge, and the recombinant protein exhibited DNase activity, indicating a direct role in host defense mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Collectively, these findings portray ENDOD1 as a multifaceted protein that may influence neuronal responses, tumor progression, and immune signaling, warranting further mechanistic exploration in both health and disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ayelet Morag, Metsada Pasmanik-Chor, Varda Oron-Karni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide expression profiling of human lymphoblastoid cell lines identifies CHL1 as a putative SSRI antidepressant response biomarker."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenomics (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/pgs.10.185"}], "href": "https://doi.org/10.2217/pgs.10.185"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21332311"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21332311"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tetsuya Idichi, Naohiko Seki, Hiroshi Kurahara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular pathogenesis of pancreatic ductal adenocarcinoma: Impact of passenger strand of pre-miR-148a on gene regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.13610"}], "href": "https://doi.org/10.1111/cas.13610"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29660218"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29660218"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Albert Quintana, Amalia Molinero, Rehannah Borup, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of astrocyte-targeted production of IL-6 on traumatic brain injury and its impact on the cortical transcriptome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Neurobiol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dneu.20584"}], "href": "https://doi.org/10.1002/dneu.20584"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18000830"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18000830"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Emma J Fenech, Federica Lari, Philip D Charles, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.57306"}], "href": "https://doi.org/10.7554/eLife.57306"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32614325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32614325"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Adaikkalam Vellaichamy, Arun Sreekumar, John R Strahler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteomic interrogation of androgen action in prostate cancer cells reveals roles of aminoacyl tRNA synthetases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0007075"}], "href": "https://doi.org/10.1371/journal.pone.0007075"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19763266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19763266"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "C G Mackintosh, J F T Griffin, I C Scott, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SOLiD SAGE sequencing shows differential gene expression in jejunal lymph node samples of resistant and susceptible red deer (Cervus elaphus) challenged with Mycobacterium avium subsp. paratuberculosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Vet Immunol Immunopathol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.vetimm.2015.10.009"}], "href": "https://doi.org/10.1016/j.vetimm.2015.10.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26620077"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26620077"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Isabela Werneck Cunha, Katia Candido Carvalho, Waleska Keller Martins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of genes associated with local aggressiveness and metastatic behavior in soft tissue tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Oncol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1593/tlo.09166"}], "href": "https://doi.org/10.1593/tlo.09166"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20165692"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20165692"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Zhe-Zhe Lyu, Bei-Bei Zhao, Keiichiro Koiwai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of endonuclease domain-containing 1 gene in Japanese flounder Paralichthys olivaceus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Fish Shellfish Immunol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.fsi.2016.01.017"}], "href": "https://doi.org/10.1016/j.fsi.2016.01.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26784919"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26784919"}]}]}]}
Proteins	ENDD1_HUMAN
NCBI Gene ID	23052
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ENDOD1 has 6,362 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 104 datasets.

Click the + buttons to view associations for ENDOD1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ENDOD1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ENDOD1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ENDOD1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ENDOD1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ENDOD1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ENDOD1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ENDOD1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ENDOD1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ENDOD1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ENDOD1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ENDOD1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ENDOD1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ENDOD1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ENDOD1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ENDOD1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ENDOD1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ENDOD1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ENDOD1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ENDOD1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ENDOD1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ENDOD1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ENDOD1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ENDOD1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ENDOD1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ENDOD1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ENDOD1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ENDOD1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ENDOD1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ENDOD1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ENDOD1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ENDOD1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ENDOD1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ENDOD1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ENDOD1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ENDOD1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ENDOD1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ENDOD1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ENDOD1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ENDOD1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ENDOD1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing ENDOD1 from the GeneSigDB Published Gene Signatures dataset.