| Name | erythroferrone |
| Description | Predicted to enable hormone activity. Predicted to be involved in several processes, including negative regulation of metabolic process; negative regulation of osteoblast differentiation; and positive regulation of signal transduction. Predicted to act upstream of or within positive regulation of fatty acid transport and regulation of fatty acid metabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Erythroferrone (ERFE) is emerging as a central erythroid regulator that coordinates iron availability with red blood cell production. In response to erythropoietin stimulation, ERFE is secreted by maturing erythroblasts and acts on the liver to suppress the synthesis of hepcidin, the key hormone governing systemic iron homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " By antagonizing the bone morphogenetic protein (BMP)–SMAD signaling pathway—particularly interfering with signals mediated by BMP5, BMP6, and BMP7—ERFE reduces hepcidin transcription, thereby increasing dietary iron absorption and promoting the mobilization of stored iron to satisfy the demands of erythropoiesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " This mechanism is essential for effective recovery from anemia and for sustaining iron flux during stress erythropoiesis, as evidenced by elevated ERFE levels following administration of erythropoiesis‐stimulating agents in various clinical settings."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Conversely, in conditions characterized by ineffective erythropoiesis such as β‑thalassemia, pathologically high production of ERFE leads to inappropriately low hepcidin levels and consequent iron overload."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Collectively, these findings underscore ERFE’s pivotal role as the link between enhanced erythropoietic activity and iron mobilization, making it a promising target for therapeutic intervention in iron‐related disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Léon Kautz, Grace Jung, Xin Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2015-07-658419"}], "href": "https://doi.org/10.1182/blood-2015-07-658419"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26276665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26276665"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "João Arezes, Niall Foy, Kirsty McHugh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Erythroferrone inhibits the induction of hepcidin by BMP6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2018-06-857995"}], "href": "https://doi.org/10.1182/blood-2018-06-857995"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30097509"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30097509"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Léon Kautz, Grace Jung, Elizabeta Nemeth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Erythroferrone contributes to recovery from anemia of inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2014-06-584607"}], "href": "https://doi.org/10.1182/blood-2014-06-584607"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25193872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25193872"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Antonella Nai, Aude Rubio, Alessandro Campanella, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2015-11-681494"}], "href": "https://doi.org/10.1182/blood-2015-11-681494"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26755707"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26755707"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Daniel N Srole, Tomas Ganz "}, {"type": "b", "children": [{"type": "t", "text": "Erythroferrone structure, function, and physiology: Iron homeostasis and beyond."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.30247"}], "href": "https://doi.org/10.1002/jcp.30247"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33372284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33372284"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hirokazu Honda, Yasuna Kobayashi, Shoko Onuma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Associations among Erythroferrone and Biomarkers of Erythropoiesis and Iron Metabolism, and Treatment with Long-Term Erythropoiesis-Stimulating Agents in Patients on Hemodialysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0151601"}], "href": "https://doi.org/10.1371/journal.pone.0151601"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26978524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26978524"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xingkang Jiang, Ming Gao, Yue Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EPO-dependent induction of erythroferrone drives hepcidin suppression and systematic iron absorption under phenylhydrazine-induced hemolytic anemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Cells Mol Dis (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bcmd.2016.02.005"}], "href": "https://doi.org/10.1016/j.bcmd.2016.02.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27067488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27067488"}]}]}]}
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| NCBI Gene ID | 151176 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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ERFE has 1,705 functional associations with biological entities spanning 6 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 24 datasets.
Click the + buttons to view associations for ERFE from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ERFE gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of ERFE gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing ERFE protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with ERFE protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with ERFE gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| GlyGen Glycosylated Proteins | ligands (chemical) binding ERFE protein from the GlyGen Glycosylated Proteins dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving ERFE gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by ERFE gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of ERFE gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of ERFE gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with ERFE gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by ERFE gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of ERFE gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of ERFE gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of ERFE gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of ERFE gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving ERFE protein from the Wikipathways PFOCR 2024 dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of ERFE gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of ERFE gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of ERFE gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ERFE protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ERFE protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with ERFE protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2024 | pathways involving ERFE protein from the WikiPathways Pathways 2024 dataset. | |
