{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In the context of cervical squamous cell carcinoma, the antisense transcript of ERICH6 (designated ERICH6.AS1) emerges as a component of an immune‐related long non‐coding RNA signature that is significantly associated with patient prognosis (6). Specifically, differential expression of ERICH6.AS1 contributed to a risk model wherein high‐risk patients—characterized by reduced CD8⁺ T cell and macrophage infiltration along with lower levels of key immune checkpoint proteins—displayed poorer survival outcomes as well as decreased sensitivity to cisplatin. These findings suggest that ERICH6.AS1 may function by modulating the tumor immune microenvironment, thereby affecting inflammatory responses and potentially serving as a prognostic biomarker and therapeutic target in cervical squamous cell carcinoma. \n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although the other abstracts in this series address diverse molecular mechanisms (e.g., ubiquitin ligase regulation in breast cancer (1), adipose tissue inflammation (2), host response genomic variations in viral infections (3), neural proteomic changes following brain stimulation (4), and oncogenic histone mutations (5)), only the study focused on cervical squamous cell carcinoma identified ERICH6.AS1 as part of a multi‐lncRNA risk signature. This highlights a novel role for ERICH6 in linking tumor biology with immune regulatory pathways."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Peter Chan, Andreas Möller, Mira C P Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/bcr2828"}], "href": "https://doi.org/10.1186/bcr2828"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21306611"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21306611"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sujoy Ghosh, Jessica L Taylor, Tamra M Mendoza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Siah2 modulates sex-dependent metabolic and inflammatory responses in adipose tissue to a high-fat diet challenge."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Sex Differ (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13293-019-0233-y"}], "href": "https://doi.org/10.1186/s13293-019-0233-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30987673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30987673"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "El Hamidi A Hay, Igseo Choi, Lingyang Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CNV Analysis of Host Responses to Porcine Reproductive and Respiratory Syndrome Virus Infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Genomics (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/jgen.20358"}], "href": "https://doi.org/10.7150/jgen.20358"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28611852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28611852"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Seung Ho Jung, Candice Hatcher-Solis, Raquel Moore, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Noninvasive Brain Stimulation Enhances Memory Acquisition and Is Associated with Synaptoneurosome Modification in the Rat Hippocampus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "eNeuro (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/ENEURO.0311-19.2019"}], "href": "https://doi.org/10.1523/ENEURO.0311-19.2019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31699891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31699891"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Matija Snuderl, Igor Dolgalev, Adriana Heguy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone H3K36I mutation in a metastatic histiocytic tumor of the skull and response to sarcoma chemotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cold Spring Harb Mol Case Stud (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/mcs.a004606"}], "href": "https://doi.org/10.1101/mcs.a004606"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31645348"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31645348"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xuefeng Lv, Lu Liu, Pengxiang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Constructing a Novel Signature Based on Immune-Related lncRNA to Improve Prognosis Prediction of Cervical Squamous Cell Carcinoma Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s43032-022-00851-z"}], "href": "https://doi.org/10.1007/s43032-022-00851-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35075611"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35075611"}]}]}]}