ESRP1 Gene

HGNC Family	RNA binding motif containing (RBM)
Name	epithelial splicing regulatory protein 1
Description	ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ESRP1 (Epithelial Splicing Regulatory Protein 1) is a master regulator of epithelial‐specific alternative splicing that plays a critical role in maintaining epithelial cell identity and suppressing epithelial–mesenchymal transition (EMT) during both development and tumor progression. ESRP1 promotes the inclusion of epithelial exons in key transcripts—for example, it favors generation of the CD44 variant isoforms (CD44v) and the FGFR2‐IIIb isoform—thereby enhancing cell–cell adhesion and limiting migratory or invasive properties ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "]."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, downregulation or transcriptional repression of ESRP1 by EMT‐inducing factors such as Snail, ZEB1, and δEF1 shifts alternative splicing toward mesenchymal isoforms—for instance, switching from CD44v to the standard isoform CD44s—which activates signaling cascades (e.g., Akt and PDGFRβ/Stat3) that enhance cell motility, invasive behavior, and cancer stem cell characteristics ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "]."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, ESRP1 plays a role in the biogenesis of circular RNAs and in regulating additional targets (such as hMENA and Exo70) that impact actin dynamics and cell morphology. In cancer contexts, ESRP1‐mediated splicing not only governs the epithelial–mesenchymal balance in primary tumors (for example, in breast, oral, pancreatic, and ovarian cancers) but also serves as a key component of feedback loops that can influence metastasis and chemoresistance ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "10"}]}, {"type": "t", "text": "]."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, comprehensive genome‐wide analyses have mapped ESRP1 binding motifs and established its broad regulatory network, underscoring its essential function in assembling an epithelial posttranscriptional gene expression program that safeguards tissue integrity and suppresses tumor progression ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "13"}]}, {"type": "t", "text": "]."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings indicate that ESRP1 is pivotal in regulating alternative splicing decisions that define epithelial versus mesenchymal phenotypes. Loss or repression of ESRP1 acts as a molecular switch that contributes to EMT, increased invasiveness, and metastasis in diverse cancers.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rhonda L Brown, Lauren M Reinke, Marin S Damerow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI44540"}], "href": "https://doi.org/10.1172/JCI44540"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21393860"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21393860"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Claude C Warzecha, Trey K Sato, Behnam Nabet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2009.01.025"}], "href": "https://doi.org/10.1016/j.molcel.2009.01.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19285943"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19285943"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Irina M Shapiro, Albert W Cheng, Nicholas C Flytzanis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1002218"}], "href": "https://doi.org/10.1371/journal.pgen.1002218"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21876675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21876675"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Claude C Warzecha, Peng Jiang, Karine Amirikian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2010.195"}], "href": "https://doi.org/10.1038/emboj.2010.195"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20711167"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20711167"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Bogdan-Tiberius Preca, Karolina Bajdak, Kerstin Mock, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.29642"}], "href": "https://doi.org/10.1002/ijc.29642"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26077342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26077342"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lauren M Reinke, Yilin Xu, Chonghui Cheng "}, {"type": "b", "children": [{"type": "t", "text": "Snail represses the splicing regulator epithelial splicing regulatory protein 1 to promote epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.397125"}], "href": "https://doi.org/10.1074/jbc.M112.397125"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22961986"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22961986"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Toshifumi Yae, Kenji Tsuchihashi, Takatsugu Ishimoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms1892"}], "href": "https://doi.org/10.1038/ncomms1892"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22673910"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22673910"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Wei Zhao, Yameng Cui, Lina Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Splicing factor derived circular RNA circUHRF1 accelerates oral squamous cell carcinoma tumorigenesis via feedback loop."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41418-019-0423-5"}], "href": "https://doi.org/10.1038/s41418-019-0423-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31570856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31570856"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Francesca Di Modugno, Pierluigi Iapicca, Aaron Boudreau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1214394109"}], "href": "https://doi.org/10.1073/pnas.1214394109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23129656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23129656"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Rahul Bhattacharya, Tulika Mitra, Susri Ray Chaudhuri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mesenchymal splice isoform of CD44 (CD44s) promotes EMT/invasion and imparts stem-like properties to ovarian cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.26504"}], "href": "https://doi.org/10.1002/jcb.26504"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29130517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29130517"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hiroki Ishii, Masao Saitoh, Kei Sakamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.589432"}], "href": "https://doi.org/10.1074/jbc.M114.589432"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25143390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25143390"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Kimberly A Dittmar, Peng Jiang, Juw Won Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide determination of a broad ESRP-regulated posttranscriptional network by high-throughput sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.06536-11"}], "href": "https://doi.org/10.1128/MCB.06536-11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22354987"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22354987"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Thomas W Bebee, Juw Won Park, Katherine I Sheridan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.08954"}], "href": "https://doi.org/10.7554/eLife.08954"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26371508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26371508"}]}]}]}
Synonyms	RMB35A, DFNB109, RBM35A
Proteins	ESRP1_HUMAN
NCBI Gene ID	54845
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ESRP1 has 7,485 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 113 datasets.

Click the + buttons to view associations for ESRP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ESRP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ESRP1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ESRP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ESRP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ESRP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ESRP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ESRP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ESRP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ESRP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ESRP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ESRP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ESRP1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ESRP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ESRP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ESRP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ESRP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with ESRP1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of ESRP1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ESRP1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ESRP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ESRP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ESRP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ESRP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ESRP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ESRP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ESRP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ESRP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ESRP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ESRP1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ESRP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving ESRP1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ESRP1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ESRP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ESRP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ESRP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ESRP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ESRP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ESRP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ESRP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ESRP1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with ESRP1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.