ETS1 Gene

HGNC Family	Helix-turn-helix ETS type domain containing
Name	v-ets avian erythroblastosis virus E26 oncogene homolog 1
Description	This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ETS1 is a multifunctional transcription factor whose activity is highly context‐dependent, contributing to diverse cellular processes including senescence, immune regulation, cancer progression, epithelial‐mesenchymal transition (EMT) and angiogenesis. In aged tissues, ETS1 can function as a transcriptional activator of the p16INK4a gene, thereby promoting cellular senescence ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "]. In the immune system, ETS1 plays key roles in lymphocyte differentiation; it is targeted by specific microRNAs (for example, miR-326) that normally restrain TH17 cell differentiation, and genetic studies have linked lower ETS1 expression to aberrant immune responses in systemic lupus erythematosus ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "]. In cancer biology, ETS1 appears to have dual roles. In colorectal cancer, for example, its expression is suppressed by miR-200c—correlating with changes in EMT markers such as E-cadherin and vimentin—suggesting that ETS1 is a key regulator in maintaining epithelial characteristics ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "]. In triple-negative breast cancer, ETS1 is implicated in an ERK-dependent pathway that downregulates BRCA1/2, potentially contributing to homologous recombination deficiency and therapeutic sensitivity ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "]. In hepatocellular carcinoma, ETS1 has been identified as a downstream effector of WTAP-mediated m6A methylation, where its post-transcriptional suppression influences cell-cycle progression via the p21/p27 axis—consistent with a tumor-suppressive role in this context ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "]. Moreover, during TGF-β-induced EMT, ETS1 acts upstream by activating the ΔEF1 (deltaEF1) promoter, thereby contributing to the repression of epithelial markers ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "]. In invasive breast cancer, ETS1 is a direct target of miR-125b; its overexpression correlates with enhanced tumor aggressiveness and poor prognosis ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "]. Finally, ETS1 cooperates with HIF-2α to stimulate transcription of key angiogenic genes such as the vascular endothelial growth factor receptor 2 (VEGFR2), underscoring its contribution to angiogenesis ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "].\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Janakiraman Krishnamurthy, Chad Torrice, Matthew R Ramsey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ink4a/Arf expression is a biomarker of aging."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI22475"}], "href": "https://doi.org/10.1172/JCI22475"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15520862"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15520862"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Changsheng Du, Chang Liu, Jiuhong Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.1798"}], "href": "https://doi.org/10.1038/ni.1798"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19838199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19838199"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wanling Yang, Nan Shen, Dong-Qing Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1000841"}], "href": "https://doi.org/10.1371/journal.pgen.1000841"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20169177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20169177"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Keun Hur, Yuji Toiyama, Masanobu Takahashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gut (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/gutjnl-2011-301846"}], "href": "https://doi.org/10.1136/gutjnl-2011-301846"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22735571"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22735571"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yasir H Ibrahim, Celina García-García, Violeta Serra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Discov (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/2159-8290.CD-11-0348"}], "href": "https://doi.org/10.1158/2159-8290.CD-11-0348"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22915752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22915752"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yunhao Chen, Chuanhui Peng, Junru Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-019-1053-8"}], "href": "https://doi.org/10.1186/s12943-019-1053-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31438961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31438961"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Takuya Shirakihara, Masao Saitoh, Kohei Miyazono "}, {"type": "b", "children": [{"type": "t", "text": "Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-beta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e07-03-0249"}], "href": "https://doi.org/10.1091/mbc.e07-03-0249"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17615296"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17615296"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yan Zhang, Li-Xu Yan, Qi-Nian Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-10-2435"}], "href": "https://doi.org/10.1158/0008-5472.CAN-10-2435"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21444677"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21444677"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Gerd Elvert, Andreas Kappel, Regina Heidenreich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M211298200"}], "href": "https://doi.org/10.1074/jbc.M211298200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12464608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12464608"}]}]}]}
Synonyms	EWSR2, ETS-1, C-ETS-1
Proteins	ETS1_HUMAN
NCBI Gene ID	2113
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ETS1 has 11,510 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 133 datasets.

Click the + buttons to view associations for ETS1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ETS1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ETS1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ETS1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ETS1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ETS1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ETS1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving ETS1 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ETS1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ETS1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ETS1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ETS1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ETS1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ETS1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ETS1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ETS1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ETS1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ETS1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ETS1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ETS1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ETS1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ETS1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ETS1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ETS1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ETS1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing ETS1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ETS1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ETS1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ETS1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ETS1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ETS1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ETS1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ETS1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving ETS1 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving ETS1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ETS1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ETS1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ETS1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ETS1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ETS1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ETS1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ETS1 gene from the ENCODE Histone Modification Site Profiles dataset.