EXOC5 Gene

Name	exocyst complex component 5
Description	The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n EXOC5 (also known as Sec10) is a central component of the exocyst complex that functions as a key regulator of targeted vesicle docking and exocytosis. Its activity is critical for numerous cellular processes including the assembly and maintenance of primary cilia, which are essential sensory organelles that mediate signal transduction and cellular homeostasis. In epithelial cells, EXOC5 facilitates proper ciliogenesis and cyst formation, and its depletion leads to the formation of cilia‐deficient cells and perturbed tissue architecture."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n EXOC5 also interacts with small GTPases such as ARF6, thereby coordinating membrane remodeling events and ensuring the targeted delivery of vesicles carrying critical cargo. This interaction underpins functions ranging from cell surface remodeling to exocytosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In addition, EXOC5 modulates extracellular vesicle (EV) biogenesis and alters the protein composition of EVs, linking ciliary function with intercellular communication."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in ciliated epithelia, tissue‐specific studies have underscored the importance of EXOC5 in development and metabolism. In the inner ear, for example, EXOC5 is essential for cochlear morphogenesis, with its loss leading to impaired development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Similarly, in skeletal muscle, conditional deletion of EXOC5 compromises insulin‐stimulated GLUT4 exocytosis and glucose uptake, thereby disturbing overall metabolic homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Furthermore, rare functional variants in EXOC5 have been implicated as risk factors for neurodegenerative disorders, suggesting that EXOC5’s role in vesicle trafficking and cellular polarity may have broad implications in human disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies highlight EXOC5 as a pivotal player in the exocyst machinery—integral for establishing and maintaining cellular polarity, directing vesicle trafficking, and ensuring proper signal transduction in diverse tissues. Its dysfunction contributes to defects in ciliogenesis, altered intercellular communication, aberrant development, and impaired metabolic regulation.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaofeng Zuo, Wei Guo, Joshua H Lipschutz "}, {"type": "b", "children": [{"type": "t", "text": "The exocyst protein Sec10 is necessary for primary ciliogenesis and cystogenesis in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e08-07-0772"}], "href": "https://doi.org/10.1091/mbc.e08-07-0772"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19297529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19297529"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Noemi Polgar, Amanda J Lee, Vanessa H Lui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The exocyst gene Sec10 regulates renal epithelial monolayer homeostasis and apoptotic sensitivity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00011.2015"}], "href": "https://doi.org/10.1152/ajpcell.00011.2015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26040895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26040895"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Magali Prigent, Thierry Dubois, Graça Raposo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ARF6 controls post-endocytic recycling through its downstream exocyst complex effector."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200305029"}], "href": "https://doi.org/10.1083/jcb.200305029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14662749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14662749"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaofeng Zuo, Sang-Ho Kwon, Michael G Janech, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Primary cilia and the exocyst are linked to urinary extracellular vesicle production and content."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA119.009297"}], "href": "https://doi.org/10.1074/jbc.RA119.009297"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31694916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31694916"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Byeonghyeon Lee, Jeong-In Baek, Hyehyun Min, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Neurobiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12035-017-0857-z"}], "href": "https://doi.org/10.1007/s12035-017-0857-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29327200"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29327200"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Brent A Fujimoto, Madison Young, Nicole Nakamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disrupted glucose homeostasis and skeletal-muscle-specific glucose uptake in an exocyst knockout mouse model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2021.100482"}], "href": "https://doi.org/10.1016/j.jbc.2021.100482"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33647317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33647317"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "David Curtis, Kaushiki Bakaya, Leona Sharma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Weighted burden analysis of exome-sequenced late-onset Alzheimer's cases and controls provides further evidence for a role for PSEN1 and suggests involvement of the PI3K/Akt/GSK-3β and WNT signalling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hum Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/ahg.12375"}], "href": "https://doi.org/10.1111/ahg.12375"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32020597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32020597"}]}]}]}
Synonyms	SEC10, SEC10L1, SEC10P, PRO1912, HSEC10
Proteins	EXOC5_HUMAN
NCBI Gene ID	10640
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

EXOC5 has 8,457 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 117 datasets.

Click the + buttons to view associations for EXOC5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

EXOC5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of EXOC5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of EXOC5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of EXOC5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of EXOC5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of EXOC5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of EXOC5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of EXOC5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of EXOC5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of EXOC5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of EXOC5 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of EXOC5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of EXOC5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with EXOC5 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with EXOC5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of EXOC5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of EXOC5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of EXOC5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of EXOC5 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing EXOC5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing EXOC5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with EXOC5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with EXOC5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing EXOC5 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of EXOC5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with EXOC5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with EXOC5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with EXOC5 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with EXOC5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with EXOC5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with EXOC5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with EXOC5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with EXOC5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at EXOC5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of EXOC5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of EXOC5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing EXOC5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with EXOC5 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with EXOC5 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of EXOC5 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with EXOC5 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.