| Name | FA core complex associated protein 20 |
| Description | Enables K63-linked polyubiquitin modification-dependent protein binding activity and ubiquitin-modified protein reader activity. Involved in interstrand cross-link repair and translesion synthesis. Located in cell junction; chromosome; and nuclear body. Part of Fanconi anaemia nuclear complex and chromatin. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FAAP20 is a critical component of the Fanconi anemia (FA) core complex that ensures effective repair of DNA interstrand crosslinks and the maintenance of genomic stability. FAAP20 directly interacts with FANCA, thereby promoting the stability of the entire core complex and facilitating the monoubiquitination of FANCD2—a pivotal activation step in the FA pathway."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " Central to its function, FAAP20 contains a conserved ubiquitin‐binding zinc finger (UBZ) domain that recognizes K63‐linked ubiquitin chains as well as monoubiquitinated proteins such as Rev1. This binding not only stabilizes Rev1 nuclear foci but also promotes interactions between the FA core complex and PCNA–Rev1 DNA damage bypass assemblies, thereby linking the FA pathway to translesion synthesis (TLS) activities."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Notably, recent structural and functional analyses have revealed that efficient ubiquitin recognition by FAAP20 extends beyond its canonical UBZ module to include a structured C‐terminal tail that reinforces binding affinity and specificity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, in vivo studies demonstrate that loss of FAAP20 leads to hallmark FA defects—including impaired FANCD2 monoubiquitination, hypersensitivity to DNA crosslinking agents, and compromised hematopoietic as well as reproductive functions—thereby underscoring its indispensable role in genome maintenance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Collectively, these findings position FAAP20 as a central mediator in coordinating ubiquitin-dependent signaling within the FA pathway and in linking DNA repair with TLS mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hyungjin Kim, Kailin Yang, Donniphat Dejsuphong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of Rev1 by the Fanconi anemia core complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.2222"}], "href": "https://doi.org/10.1038/nsmb.2222"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22266823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22266823"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Abdullah Mahmood Ali, Arun Pradhan, Thiyam Ramsingh Singh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-10-385963"}], "href": "https://doi.org/10.1182/blood-2011-10-385963"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22343915"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22343915"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Justin Wai Chung Leung, Yucai Wang, Ka Wing Fong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1118720109"}], "href": "https://doi.org/10.1073/pnas.1118720109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22396592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22396592"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jessica L Wojtaszek, Su Wang, Hyungjin Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin recognition by FAAP20 expands the complex interface beyond the canonical UBZ domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gku1153"}], "href": "https://doi.org/10.1093/nar/gku1153"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25414354"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25414354"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kyungeun Lim, Mi-Kyung Lee, Phuong T M Duong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biophysical characterization of the interaction between FAAP20-UBZ4 domain and Rev1-BRCT domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2015.08.021"}], "href": "https://doi.org/10.1016/j.febslet.2015.08.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26318859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26318859"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Tingting Zhang, Andrew F Wilson, Abdullah Mahmood Ali, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of Faap20 Causes Hematopoietic Stem and Progenitor Cell Depletion in Mice Under Genotoxic Stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.2048"}], "href": "https://doi.org/10.1002/stem.2048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25917546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25917546"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Zhijiang Yan, Rong Guo, Manikandan Paramasivam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2012.05.026"}], "href": "https://doi.org/10.1016/j.molcel.2012.05.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22705371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22705371"}]}]}]}
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| NCBI Gene ID | 199990 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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FAAP20 has 1,698 functional associations with biological entities spanning 6 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 26 datasets.
Click the + buttons to view associations for FAAP20 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of FAAP20 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of FAAP20 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing FAAP20 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with FAAP20 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with FAAP20 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving FAAP20 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing FAAP20 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by FAAP20 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of FAAP20 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of FAAP20 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of FAAP20 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with FAAP20 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of FAAP20 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of FAAP20 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of FAAP20 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving FAAP20 protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2024 | pathways involving FAAP20 protein from the Reactome Pathways 2024 dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of FAAP20 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of FAAP20 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of FAAP20 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of FAAP20 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of FAAP20 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sci-Plex Drug Perturbation Signatures | drug perturbations changing expression of FAAP20 gene from the Sci-Plex Drug Perturbation Signatures dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of FAAP20 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with FAAP20 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2024 | pathways involving FAAP20 protein from the WikiPathways Pathways 2024 dataset. | |
