| Name | FA core complex associated protein 24 |
| Description | FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FAAP24 is a key component of the Fanconi anemia (FA) DNA damage response pathway. It functions primarily as a binding partner of FANCM, helping to target and stabilize the FA core complex at sites of stalled replication forks and DNA interstrand crosslinks. Its intrinsic DNA‐binding activity enables FAAP24 to recognize and bind to DNA structures that mimic repair intermediates, thereby facilitating the proper recruitment of repair proteins. In particular, FAAP24 is essential for achieving normal FANCD2 monoubiquitination—a critical modification for FA pathway activation—and for the efficient assembly of repair factors, including the recruitment of replication protein A (RPA) at DNA damage sites. This role not only supports the assembly of a repair-competent complex but also promotes ATR/Chk1‐mediated checkpoint signaling. In the absence of FAAP24, FANCM becomes destabilized and mislocalized from chromatin, leading to defective checkpoint responses, hypersensitivity to DNA crosslinking agents, and consequent genomic instability."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alberto Ciccia, Chen Ling, Rachel Coulthard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2007.01.003"}], "href": "https://doi.org/10.1016/j.molcel.2007.01.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17289582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17289582"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Spencer J Collis, Alberto Ciccia, Andrew J Deans, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2008.10.014"}], "href": "https://doi.org/10.1016/j.molcel.2008.10.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18995830"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18995830"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Min Huang, Jung Min Kim, Bunsyo Shiotani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2010.07.005"}], "href": "https://doi.org/10.1016/j.molcel.2010.07.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20670894"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20670894"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jung Min Kim, Younghoon Kee, Allan Gurtan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-09-113092"}], "href": "https://doi.org/10.1182/blood-2007-09-113092"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18174376"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18174376"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yucai Wang, Justin W Leung, Yingjun Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2012.12.010"}], "href": "https://doi.org/10.1016/j.molcel.2012.12.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23333308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23333308"}]}]}]}
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| NCBI Gene ID | 91442 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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FAAP24 has 1,510 functional associations with biological entities spanning 5 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 35 datasets.
Click the + buttons to view associations for FAAP24 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of FAAP24 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of FAAP24 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with FAAP24 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of FAAP24 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI U2OS Cell Map Protein Localization Assemblies | assemblies containing FAAP24 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing FAAP24 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing FAAP24 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with FAAP24 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of FAAP24 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by FAAP24 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with FAAP24 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with FAAP24 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving FAAP24 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving FAAP24 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing FAAP24 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing FAAP24 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of FAAP24 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with FAAP24 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of FAAP24 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of FAAP24 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| KEGG Pathways 2026 | pathways involving FAAP24 protein from the KEGG Pathways 2026 dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of FAAP24 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of FAAP24 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving FAAP24 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving FAAP24 protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2024 | pathways involving FAAP24 protein from the Reactome Pathways 2024 dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of FAAP24 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of FAAP24 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of FAAP24 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of FAAP24 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sci-Plex Drug Perturbation Signatures | drug perturbations changing expression of FAAP24 gene from the Sci-Plex Drug Perturbation Signatures dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of FAAP24 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of FAAP24 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with FAAP24 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2024 | pathways involving FAAP24 protein from the WikiPathways Pathways 2024 dataset. | |
