{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FAM102A, which is also known as early estrogen‐induced gene 1 (EEIG1), has emerged as a multifunctional protein implicated in diverse cellular processes. In estrogen‐responsive contexts, FAM102A/EEIG1 is rapidly induced in estrogen receptor–positive cells and appears to play a role in mediating estrogen signaling (for instance, in MCF‑7 breast cancer cells)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, FAM102A/EEIG1 has been shown to participate in receptor activator of NF‑κB ligand (RANKL)–stimulated signaling cascades that regulate osteoclast formation; it interacts with key signaling mediators such as Gab2, PLCγ2, and kinases (including Tec/Btk) to promote the phosphorylation events that lead to NFATc1 induction and osteoclastogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In parallel, genetic association studies have repeatedly implicated a locus spanning DPM2–FAM102A in ocular disorders. Multiple genome‐wide analyses have associated single nucleotide polymorphisms in this region with primary angle closure suspect (PACS) and primary angle closure glaucoma (PACG), suggesting that FAM102A may contribute to the anatomical or developmental pathways that underlie narrow angle configurations in the eye."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additional data indicate that FAM102A might play a role beyond estrogen and bone biology. For example, in a genome‐wide association study of sex determination in fish, FAM102A was identified among candidate genes in a sex‐associated genomic region, implying a potential involvement in gonadal differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Furthermore, proteomic mapping of the SKAP2 interactome uncovered FAM102A as a novel binding partner, linking it to SRC family kinase–mediated signaling and suggesting that it could influence actin polymerization, cell migration, and possibly oncogenic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, FAM102A/EEIG1 is emerging as a versatile protein that integrates estrogen signaling and bone remodeling via modulation of RANKL-induced osteoclastogenesis, contributes to genetic susceptibility in ocular angle-closure diseases, and may also have roles in sex determination and cytoskeletal regulation through its interaction with key adaptor proteins. \n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dong-Yu Wang, Roberta Fulthorpe, Steven N Liss, et al. 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