{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Family with sequence similarity 107, member A (FAM107A)—also known as DRR1 or TU3A—is a multifunctional protein whose activities appear to be highly context dependent. In the central nervous system, FAM107A plays important roles in neurodevelopment and stress responses. It binds to and bundles actin filaments, thereby stabilizing the cytoskeleton to influence neurite outgrowth, synapse formation, and neural stem cell differentiation. In addition, its stress‐ and glucocorticoid‐induced upregulation has been linked to adaptive changes that may contribute to stress resilience as well as to the progression of neurodegenerative processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a variety of human cancers—including renal cell carcinoma, glioblastoma, lung, bladder, laryngeal, colorectal, and prostate carcinomas—FAM107A expression is frequently reduced, often through mechanisms such as promoter hypermethylation or chromosomal loss. This downregulation is associated with enhanced tumor cell invasion, epithelial‐to‐mesenchymal transition, aggressive disease progression, and poor clinical outcome, suggesting that FAM107A normally acts as a tumor suppressor."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, recent evidence in metabolic studies indicates that FAM107A can negatively regulate the browning of white adipocytes, thereby influencing mitochondrial biogenesis and the expression of key thermogenic markers. This function points to a potential role in maintaining metabolic homeostasis and suggests that FAM107A may be an attractive target for therapeutic intervention in obesity‐related disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, the studies indicate that FAM107A supports neuronal cell survival and appropriate differentiation by modulating actin dynamics in response to stress, while its loss in various cancers removes an important restraint on proliferation and invasion. These multifaceted roles underscore its potential value both as a diagnostic biomarker and as a therapeutic target across neurological and oncological disease contexts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mathias V Schmidt, Jan-Philip Schülke, Claudia Liebl, et al. 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