{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FAM110A is a member of a newly characterized family of proteins that localizes to centrosomes and spindle poles, exhibiting cell cycle–regulated expression and playing a critical role in mitotic progression. Initial studies demonstrated that FAM110A, along with its family members, accumulates at the microtubule‐organizing center during interphase and at the spindle poles during mitosis, suggesting important functions in spindle organization and cell division."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " More detailed functional analyses revealed that FAM110A is highly expressed in the G2 phase and that its proper phosphorylation by casein kinase I is essential for efficient chromosomal alignment, timely metaphase‐to‐anaphase transition, and accurate spindle positioning during mitosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its established role in cell cycle regulation, FAM110A has emerged in a number of genomic studies as a candidate gene associated with diverse clinical conditions. Genome‐wide analyses have identified FAM110A as significantly linked to depressive symptom burden in older adults, suggesting that alterations in this gene may contribute to neuropsychiatric phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, differential expression studies in hypertension models have found FAM110A to be among the genes whose altered expression may relate to inflammatory and metabolic processes, further implicating it in cardiovascular pathology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the oncologic setting, FAM110A—formerly designated as C20orf55—has been incorporated into multi‐gene methylation panels for outcome prediction in breast cancer. Aberrant DNA methylation of this gene, in combination with other markers, has been associated with clinical outcome in anthracycline‐treated, estrogen receptor–positive, lymph node–positive breast cancer patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Together, these findings highlight FAM110A as a multifunctional protein involved in the regulation of mitosis and as a potential biomarker in diverse disease contexts, ranging from neuropsychiatric and cardiovascular disorders to cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Helena Hauge, Sebastian Patzke, Hans-Christian Aasheim "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of the FAM110 gene family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygeno.2007.03.002"}], "href": "https://doi.org/10.1016/j.ygeno.2007.03.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17499476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17499476"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Cecilia Aquino Perez, Monika Burocziova, Gabriela Jenikova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CK1-mediated phosphorylation of FAM110A promotes its interaction with mitotic spindle and controls chromosomal alignment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.202051847"}], "href": "https://doi.org/10.15252/embr.202051847"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34080749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34080749"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kwangsik Nho, Vijay K Ramanan, Emrin Horgusluoglu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive gene- and pathway-based analysis of depressive symptoms in older adults."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Alzheimers Dis (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/JAD-148009"}], "href": "https://doi.org/10.3233/JAD-148009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25690665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25690665"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kuang-Mao Chiang, Hsin-Chou Yang, Wen-Harn Pan "}, {"type": "b", "children": [{"type": "t", "text": "A Two-Stage Whole-Genome Gene Expression Association Study of Young-Onset Hypertension in Han Chinese Population of Taiwan."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-19520-w"}], "href": "https://doi.org/10.1038/s41598-018-19520-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29379041"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29379041"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Oliver Hartmann, Frédérique Spyratos, Nadia Harbeck, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA methylation markers predict outcome in node-positive, estrogen receptor-positive breast cancer with adjuvant anthracycline-based chemotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-08-0166"}], "href": "https://doi.org/10.1158/1078-0432.CCR-08-0166"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19118060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19118060"}]}]}]}