FAM157A Gene

Name family with sequence similarity 157, member A
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although the precise molecular function of FAM157A remains to be fully elucidated, recent studies provide early evidence that points to its potential involvement in pathological processes. In one study focused on carotid paragangliomas, whole‐exome sequencing of tumor samples identified FAM157A among a set of genes with a high mutation rate, suggesting that alterations in FAM157A may be implicated in tumor initiation and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a separate investigation profiling plasma proteins in patients infected with the 2011 H1N1 influenza virus, FAM157A was found to be significantly differentially expressed compared to healthy controls. This altered expression pattern indicates that FAM157A could serve as a potential biomarker for H1N1 infection, hinting at a role in the host response to viral challenge."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these observations implicate FAM157A in both oncogenic and infectious contexts. Given the current data, further investigation into its molecular mechanisms is warranted to determine whether FAM157A may contribute to disease pathogenesis and be harnessed for diagnostic or therapeutic applications.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "A V Snezhkina, E N Lukyanova, M S Fedorova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Novel Genes Associated with the Development of Carotid Paragangliomas]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol (Mosk) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1134/S0026898419040141"}], "href": "https://doi.org/10.1134/S0026898419040141"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31397435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31397435"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Seonyoung Choi, Ji-youn Lim, Yoonjin Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plasma proteomic analysis of patients infected with H1N1 influenza virus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proteomics (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pmic.201400030"}], "href": "https://doi.org/10.1002/pmic.201400030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24888898"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24888898"}]}]}]}
Synonyms GTF2IP18
Proteins F157A_HUMAN
NCBI Gene ID 728262
API
Download Associations
Predicted Functions View FAM157A's ARCHS4 Predicted Functions.
Co-expressed Genes View FAM157A's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View FAM157A's ARCHS4 Predicted Functions.

Functional Associations

FAM157A has 1,170 functional associations with biological entities spanning 4 categories (molecular profile, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 20 datasets.

Click the + buttons to view associations for FAM157A from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of FAM157A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of FAM157A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of FAM157A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of FAM157A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of FAM157A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of FAM157A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with FAM157A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with FAM157A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at FAM157A gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of FAM157A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of FAM157A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of FAM157A gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of FAM157A gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of FAM157A gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of FAM157A gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of FAM157A gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of FAM157A gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of FAM157A gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of FAM157A gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of FAM157A protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.