{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although neither study was designed specifically to characterize FAM166A, clues about its potential role can be gleaned from the contexts in which it is mentioned. In one study, a detailed, manual re‐annotation of homeobox gene clusters uncovered a complex landscape of protein‐coding genes and associated antisense long non‐coding RNAs known to regulate key developmental processes such as pattern formation during embryogenesis. Within this framework, genes like FAM166A are situated in genomic regions that may be functionally intertwined with regulatory networks orchestrated by antisense RNAs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a separate investigation employing systems biology approaches to study spermatogenesis and male infertility, differential gene expression analyses highlighted various genes potentially implicated in the regulatory processes underlying germ cell development. Although FAM166A was not the primary focus, its inclusion among transcripts altered in infertility models suggests that it might contribute to the network of genes modulating cell differentiation and tissue-specific regulatory functions during spermatogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, while a definitive biochemical function for FAM166A remains to be established, the available data hint that it could play a regulatory role within gene expression networks that govern both embryonic patterning and reproductive processes.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Laurens G Wilming, Veronika Boychenko, Jennifer L Harrow "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive comparative homeobox gene annotation in human and mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Database (Oxford) (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/database/bav091"}], "href": "https://doi.org/10.1093/database/bav091"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26412852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26412852"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Seyed Morteza Razavi, Marjan Sabbaghian, Mahdi Jalili, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive functional enrichment analysis of male infertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-16005-0"}], "href": "https://doi.org/10.1038/s41598-017-16005-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29150651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29150651"}]}]}]}