{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FAM181B is a member of the Fam181 gene family that encodes conserved nuclear proteins and appears to play diverse roles during development and in adult physiology. In murine embryos, FAM181B displays a cyclic expression pattern in the presomitic mesoderm that is in phase with Notch‐regulated targets, suggesting a role in the regulation of somitogenesis, even though its loss‐of‐function did not result in an obvious phenotype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, structural and binding analyses have revealed that FAM181B interacts directly with TEAD transcription factors through an Ω‐loop and a conserved LxxLF motif, a binding mode reminiscent of co-regulators such as YAP and TAZ. This interaction implicates FAM181B in Hippo pathway signaling and suggests that it could influence transcriptional programs required for tissue development, including that of the nervous system."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its developmental roles, FAM181B has also emerged in genome-wide association studies as a candidate gene near significant single-nucleotide polymorphism markers associated with growth traits in chickens, indicating a potential connection between FAM181B and organismal growth or metabolic regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Furthermore, investigations into the Fam181 gene family, including its closely related paralog FAM181A, help to contextualize FAM181B’s conserved function and underline possible overlapping roles in diverse tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings suggest that FAM181B is involved in the modulation of developmental oscillatory processes and transcriptional regulation via the TEAD family, while also potentially impacting growth-related traits. Although certain loss-of-function studies indicate that its role may be compensated by paralogous family members under some conditions, the conservation of key motifs and binding interactions supports an important, albeit context-dependent, function for FAM181B.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Matthias Marks, Tracie Pennimpede, Lisette Lange, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of the Fam181 gene family during mouse development reveals distinct strain-specific expression patterns, suggesting a role in nervous system development and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2015.09.035"}], "href": "https://doi.org/10.1016/j.gene.2015.09.035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26407640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26407640"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fedir Bokhovchuk, Yannick Mesrouze, Clara Delaunay, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pro.3775"}], "href": "https://doi.org/10.1002/pro.3775"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31697419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31697419"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Fuwei Li, Haixia Han, Qiuxia Lei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of body weight in Wenshang Barred chicken based on the SLAF-seq technology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Appl Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13353-018-0452-7"}], "href": "https://doi.org/10.1007/s13353-018-0452-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29946990"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29946990"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wasim Shah, Ranjha Khan, Basit Shah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockout of the family with sequence similarity 181, member A ("}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Fam181a"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": ") gene does not impair spermatogenesis or male fertility in the mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Fertil Dev (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1071/RD21150"}], "href": "https://doi.org/10.1071/RD21150"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34253288"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34253288"}]}]}]}