{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nFAM197Y3, corresponding to the novel member SLC10A7 (previously known as C4orf13) of the solute carrier family, encodes a protein of 340–343 amino acids that is structurally distinct from other SLC10 family proteins. Unlike its relatives that typically have seven-transmembrane domains, FAM197Y3 exhibits a unique topology comprising 10 transmembrane domains with both the N‐ and C‐termini located intracellularly. Functional expression studies in Xenopus laevis oocytes and HEK293 cells revealed that although the protein is targeted to the plasma membrane, it does not mediate the transport of bile acids or steroid sulfates, suggesting that it may perform a non‐canonical role in cellular physiology. In addition, the broad tissue expression pattern and the remarkable evolutionary conservation of FAM197Y3—from bacteria and plants to vertebrates—imply that this protein could be involved in fundamental cellular processes such as membrane organization or signaling rather than classical solute transport. Further research is needed to fully elucidate the biological mechanisms and physiological impact of this widespread carrier."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "José R Godoy, Carla Fernandes, Barbara Döring, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular and phylogenetic characterization of a novel putative membrane transporter (SLC10A7), conserved in vertebrates and bacteria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejcb.2007.06.001"}], "href": "https://doi.org/10.1016/j.ejcb.2007.06.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17628207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17628207"}]}]}]}