{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The collection of abstracts provided spans a broad range of biomedical topics—including estrogen‐mediated cell proliferation and endocrine resistance in breast cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", metabolic and epigenetic differences in the colon mucosa in cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", gene coexpression networks in spinocerebellar ataxias"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", cell‐surface proteomics in human pluripotent stem cells"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", mechanisms of 3′ untranslated region diversification via Alu exonisation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", imaging genetics using latent factor regression models"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", exomic variation in Arab populations"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", and genetic influences on psychotic experiences"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", as well as investigations of human endogenous retroviral sequences."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n However, none of these abstracts specifically address or discuss the function of FAM216A. As such, no direct functional insights or mechanistic details regarding FAM216A can be gleaned from the provided studies. FAM216A, which belongs to a family of genes with sequence similarity, remains uncharacterized in the context of the investigations highlighted by these abstracts. Further targeted research would be necessary to determine its biological role, its regulation, and any potential contributions to the diverse cellular and molecular pathways reviewed, ranging from hormonal signaling to neuronal function and beyond.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Elizabeth A Musgrove, C Marcelo Sergio, Sherene Loi, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic differences in normal colon mucosa of cancer patients suggest altered dietary metabolic pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Prev Res (Phila) (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1940-6207.CAPR-11-0336"}], "href": "https://doi.org/10.1158/1940-6207.CAPR-11-0336"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22300984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22300984"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Conceição Bettencourt, Mina Ryten, Paola Forabosco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insights from cerebellar transcriptomic analysis into the pathogenesis of ataxia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JAMA Neurol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1001/jamaneurol.2014.756"}], "href": "https://doi.org/10.1001/jamaneurol.2014.756"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24862029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24862029"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kenneth R Boheler, Subarna Bhattacharya, Erin M Kropp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A human pluripotent stem cell surface N-glycoproteome resource reveals markers, extracellular epitopes, and drug targets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cell Reports (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stemcr.2014.05.002"}], "href": "https://doi.org/10.1016/j.stemcr.2014.05.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25068131"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25068131"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Mojca Tajnik, Alessandra Vigilante, Simon Braun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intergenic Alu exonisation facilitates the evolution of tissue-specific transcript ends."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkv956"}], "href": "https://doi.org/10.1093/nar/gkv956"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26400176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26400176"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Chenyang Tao, Thomas E Nichols, Xue Hua, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Generalized reduced rank latent factor regression for high dimensional tensor fields, and neuroimaging-genetic applications."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroimage (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroimage.2016.08.027"}], "href": "https://doi.org/10.1016/j.neuroimage.2016.08.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27666385"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27666385"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Sumi Elsa John, Dinu Antony, Muthukrishnan Eaaswarkhanth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Assessment of coding region variants in Kuwaiti population: implications for medical genetics and population genomics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-34815-8"}], "href": "https://doi.org/10.1038/s41598-018-34815-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30409984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30409984"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Wikus Barkhuizen, Oliver Pain, Frank Dudbridge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic overlap between psychotic experiences in the community across age and with psychiatric disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41398-020-0765-2"}], "href": "https://doi.org/10.1038/s41398-020-0765-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32152294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32152294"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "H S Kim, T J Crow "}, {"type": "b", "children": [{"type": "t", "text": "Presence and phylogenetic analysis of HERV-K LTR on human X and Y chromosomes: evidence for recent proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Genet Syst (1999)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1266/ggs.74.267"}], "href": "https://doi.org/10.1266/ggs.74.267"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "10734608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/10734608"}]}]}]}