FAM234B Gene

Name family with sequence similarity 234 member B
Description Predicted to be located in Golgi apparatus; membrane; and microtubule organizing center. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent investigations into FAM234B, a member of the “family with sequence similarity 234,” have highlighted its potential involvement in neurodevelopment. Bioinformatics as well as experimental analyses of its expression pattern have indicated that FAM234B is enriched in the nervous system, implying that it may contribute to the regulation of neural development and function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, exome‐sequencing studies in consanguineous families with neurodevelopmental disorders and intellectual disability have identified homozygous truncating variants in FAM234B among several candidate genes, suggesting that loss‐of-function in FAM234B could underlie some neurodevelopmental deficits."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Although the precise molecular mechanisms remain to be fully elucidated, these findings collectively point to a role for FAM234B in maintaining proper neurodevelopment; disruption of its normal function may contribute to developmental pathologies. Further studies are warranted to explore its functional interactions and downstream signaling pathways in the developing brain.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lijuan Lyu, Meng Wang, Yi Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "FAM234B"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Predicts Poor Prognosis in Patients with Luminal Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S280009"}], "href": "https://doi.org/10.2147/CMAR.S280009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33299353"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33299353"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Miriam S Reuter, Hasan Tawamie, Rebecca Buchert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diagnostic Yield and Novel Candidate Genes by Exome Sequencing in 152 Consanguineous Families With Neurodevelopmental Disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JAMA Psychiatry (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1001/jamapsychiatry.2016.3798"}], "href": "https://doi.org/10.1001/jamapsychiatry.2016.3798"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28097321"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28097321"}]}]}]}
NCBI Gene ID 57613
API
Download Associations
Predicted Functions View FAM234B's ARCHS4 Predicted Functions.
Co-expressed Genes View FAM234B's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View FAM234B's ARCHS4 Predicted Functions.

Functional Associations

FAM234B has 2,096 functional associations with biological entities spanning 6 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 31 datasets.

Click the + buttons to view associations for FAM234B from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of FAM234B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
Carcinogenome Chemical Perturbation Carcinogenicity Signatures small molecule perturbations changing expression of FAM234B gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
CCLE Cell Line Proteomics Cell lines associated with FAM234B protein from the CCLE Cell Line Proteomics dataset.
CellMarker Gene-Cell Type Associations cell types associated with FAM234B gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of FAM234B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of FAM234B gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
CM4AI U2OS Cell Map Protein Localization Assemblies assemblies containing FAM234B protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 cellular components containing FAM234B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with FAM234B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
DeepCoverMOA Drug Mechanisms of Action small molecule perturbations with high or low expression of FAM234B protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by FAM234B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with FAM234B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with FAM234B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
GTEx eQTL 2025 SNPs regulating expression of FAM234B gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of FAM234B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue-Specific Aging Signatures tissue samples with high or low expression of FAM234B gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
GWAS Catalog SNP-Phenotype Associations 2025 phenotypes associated with FAM234B gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of FAM234B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of FAM234B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of FAM234B gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures gene perturbations changing expression of FAM234B gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by FAM234B gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MoTrPAC Rat Endurance Exercise Training tissue samples with high or low expression of FAM234B gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of FAM234B gene from the NIBR DRUG-seq U2OS MoA Box dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of FAM234B gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of FAM234B gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of FAM234B gene from the RummaGEO Gene Perturbation Signatures dataset.
Sci-Plex Drug Perturbation Signatures drug perturbations changing expression of FAM234B gene from the Sci-Plex Drug Perturbation Signatures dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of FAM234B protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of FAM234B protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with FAM234B protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.