{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FAM25C, a member of the FAM25 gene family, has recently been identified as a promising salivary extracellular RNA biomarker for gingival inflammation. In studies focused on non‐invasive diagnostics for periodontal disease, FAM25C was included (along with markers such as SPRR1A, lnc‐TET3-2:1, and CRCT1) in a panel that demonstrated robust performance for gingivitis detection and monitoring, with an area under the curve of 0.91, 71% sensitivity, and 100% specificity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although its diagnostic utility is evident through consistent expression changes correlating with disease regression, the underlying biological function of FAM25C remains poorly defined. In contrast to other investigations that elucidate mechanistic pathways in contexts such as cancer spheroid formation and drug‐induced toxicity"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "9"}]}, {"type": "t", "text": ", the current evidence suggests that FAM25C primarily serves as a biomarker rather than an active effector in disease pathogenesis. Further studies are warranted to determine whether FAM25C plays additional roles in cellular processes or might participate in regulatory networks that contribute to the pathophysiology of periodontal disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Karolina E Kaczor-Urbanowicz, Harsh M Trivedi, Patricia O Lima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Salivary exRNA biomarkers to detect gingivitis and monitor disease regression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Periodontol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcpe.12930"}], "href": "https://doi.org/10.1111/jcpe.12930"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29779262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29779262"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Erin Faulkner, Adelaide Mensah, Aoife M Rodgers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Role of Epigenetic and Biological Biomarkers in the Diagnosis of Periodontal Disease: A Systematic Review Approach."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diagnostics (Basel) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/diagnostics12040919"}], "href": "https://doi.org/10.3390/diagnostics12040919"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35453967"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35453967"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "S Condello, C A Morgan, S Nagdas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2014.178"}], "href": "https://doi.org/10.1038/onc.2014.178"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24954508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24954508"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaoqin He, Yongfa Zheng, Yuefeng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA AK058003, as a precursor of miR-15a, interacts with HuR to inhibit the expression of γ-synuclein in hepatocellular carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.14276"}], "href": "https://doi.org/10.18632/oncotarget.14276"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28035067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28035067"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Rong Qiu, Chao Chen, Hong Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Large genomic region free of GWAS-based common variants contains fertility-related genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0061917"}], "href": "https://doi.org/10.1371/journal.pone.0061917"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23613972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23613972"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Martin Otava, Ziv Shkedy, Willem Talloen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of in vitro and in vivo disconnects using transcriptomic data."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-015-1726-7"}], "href": "https://doi.org/10.1186/s12864-015-1726-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26282683"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26282683"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Mandana Arbab, Sharanya Srinivasan, Tatsunori Hashimoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cloning-free CRISPR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cell Reports (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stemcr.2015.09.022"}], "href": "https://doi.org/10.1016/j.stemcr.2015.09.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26527385"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26527385"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Felicita F Jusof, Supun M Bakmiwewa, Silvia Weiser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Investigation of the Tissue Distribution and Physiological Roles of Indoleamine 2,3-Dioxygenase-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Tryptophan Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1178646917735098"}], "href": "https://doi.org/10.1177/1178646917735098"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29051706"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29051706"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Tiantian Zhang, Zhuqiang Zhang, Qiang Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone H3K27 acetylation is dispensable for enhancer activity in mouse embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13059-020-01957-w"}], "href": "https://doi.org/10.1186/s13059-020-01957-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32085783"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32085783"}]}]}]}