{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FAM83H‐AS1 is an oncogenic long non‑coding RNA that has been found to be dysregulated across a wide range of human cancers – including cervical, ovarian, lung, gastric, colorectal, hepatocellular, esophageal, bladder, breast, and prostate cancers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "14"}]}, {"type": "t", "text": " In multiple studies, aberrant overexpression of FAM83H‐AS1 has been correlated with enhanced cellular proliferation, migration, invasion, and cell cycle progression; reduced apoptosis; and even the acquisition of chemoresistance. Its upregulation is further associated with advanced clinical stage and poorer overall patient survival."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Mechanistically, FAM83H‐AS1 has been shown to act through diverse molecular routes. It frequently functions as a competing endogenous RNA by “sponging” tumor‐suppressive microRNAs (for example, miR‑485‑5p, miR‑136‑5p, and miR‑10a‑5p), which in turn releases key oncogenic effectors. In other settings, FAM83H‐AS1 interacts with RNA–binding proteins such as HuR and HNRNPK – thereby stabilizing the expression of genes that drive tumor progression – or recruits chromatin‐modifying complexes (for instance, via EZH2) to silence tumor suppressor genes. These multifaceted actions modulate crucial signaling pathways including Wnt/β‑catenin, MET/EGFR, Notch, and TGF‑β signaling."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings suggest that FAM83H‐AS1 functions as a master regulator of oncogenesis and metastasis. Its consistent overexpression across multiple cancer types and its impact on pathways governing cell proliferation, survival, migration, and therapy resistance underscore its potential both as a prognostic biomarker and as a therapeutic target in cancer management (2, 4, 6, 8, 10, 11, 13, 14).\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n "}, {"type": "b", "children": [{"type": "t", "text": "References:"}]}, {"type": "t", "text": "<br>\n (1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "<br>\n (2)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "<br>\n (3)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "<br>\n (4)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "<br>\n (5)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "<br>\n (6)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "<br>\n (7)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "<br>\n (8)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "<br>\n (9)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "<br>\n (10)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "<br>\n (11)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "<br>\n (12)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "<br>\n (13)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "<br>\n (14)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Christopher R Cabanski, Nicole M White, Ha X Dang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pan-cancer transcriptome analysis reveals long noncoding RNAs with conserved function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15476286.2015.1038012"}], "href": "https://doi.org/10.1080/15476286.2015.1038012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25864709"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25864709"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jamie A Barr, Karen E Hayes, Tayvia Brownmiller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA FAM83H-AS1 is regulated by human papillomavirus 16 E6 independently of p53 in cervical cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-40094-8"}], "href": "https://doi.org/10.1038/s41598-019-40094-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30842470"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30842470"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qianru Dou, Yang Xu, Yuanyuan Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA FAM83H-AS1 contributes to the radioresistance, proliferation, and metastasis in ovarian cancer through stabilizing HuR protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Pharmacol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejphar.2019.03.002"}], "href": "https://doi.org/10.1016/j.ejphar.2019.03.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30831080"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30831080"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jie Zhang, Shumei Feng, Wenmei Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of FAM83H-AS1 indicates poor patient survival and knockdown impairs cell proliferation and invasion via MET/EGFR signaling in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep42819"}], "href": "https://doi.org/10.1038/srep42819"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28198463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28198463"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nahla E El-Ashmawy, Fatma Z Hussien, Ola A El-Feky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum LncRNA-ATB and FAM83H-AS1 as diagnostic/prognostic non-invasive biomarkers for breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2020.118193"}], "href": "https://doi.org/10.1016/j.lfs.2020.118193"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32763293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32763293"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hui Shan, Yunbo Yang, Xuhui Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM83H-AS1 is associated with clinical progression and modulates cell proliferation, migration, and invasion in bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27758"}], "href": "https://doi.org/10.1002/jcb.27758"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30537032"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30537032"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lei Yang, Jinpeng Cui, Yakun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM83H-AS1 is upregulated and predicts poor prognosis in colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2019.109342"}], "href": "https://doi.org/10.1016/j.biopha.2019.109342"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31545230"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31545230"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Y-K Ma, T-H Shen, X-Y Yang "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of LncRNA FAM83H-AS1 in hepatocellular carcinoma promotes cell proliferation, migration and invasion by Wnt/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201909_18995"}], "href": "https://doi.org/10.26355/eurrev_201909_18995"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31599410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31599410"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yong-Yan Bi, Gang Shen, Yong Quan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA FAM83H-AS1 exerts an oncogenic role in glioma through epigenetically silencing CDKN1A (p21)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.26813"}], "href": "https://doi.org/10.1002/jcp.26813"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29870057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29870057"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Bo Liu, Duocheng Qian, Weidong Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Novel Androgen-Induced lncRNA FAM83H-AS1 Promotes Prostate Cancer Progression "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " the miR-15a/CCNE2 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2020.620306"}], "href": "https://doi.org/10.3389/fonc.2020.620306"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33614501"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33614501"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Chunyong Han, Yiwei Fu, Ni Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA FAM83H-AS1 promotes triple-negative breast cancer progression by regulating the miR-136-5p/metadherin axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.102832"}], "href": "https://doi.org/10.18632/aging.102832"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32074085"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32074085"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Wenpeng Zhao, Jiang Guo, Honglu Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM83H-AS1/miR-485-5p/MEF2D axis facilitates proliferation, migration and invasion of hepatocellular carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-021-08923-0"}], "href": "https://doi.org/10.1186/s12885-021-08923-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34876040"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34876040"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Qin Yang, Jie Wang, Pingyong Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The clinical prognostic value of lncRNA FAM83H-AS1 in cancer patients: a meta-analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-020-1148-8"}], "href": "https://doi.org/10.1186/s12935-020-1148-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32165862"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32165862"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Lei Yang, Lingling Xu, Qian Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dysregulation of long non-coding RNA profiles in human colorectal cancer and its association with overall survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2016.5138"}], "href": "https://doi.org/10.3892/ol.2016.5138"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27895773"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27895773"}]}]}]}