FAT1 Gene

HGNC Family	Cadherins
Name	FAT atypical cadherin 1
Description	This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FAT1, a member of the atypical cadherin family, plays multifaceted roles in regulating cell–cell adhesion, actin cytoskeletal organization, cell polarity, and migration, and it influences key signaling pathways involved in tumorigenesis. In several human cancers—including esophageal squamous cell carcinoma, glioblastoma, colorectal carcinoma, and head and neck cancers—FAT1 functions principally as a tumor suppressor by interacting with β‐catenin to limit its nuclear translocation and dampen Wnt pathway activation, thereby constraining cell proliferation and epithelial‐to‐mesenchymal transition (EMT)."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Complementing these findings, functional studies have demonstrated that FAT1 localizes at dynamic actin structures—filopodial tips, lamellipodial edges, and cell–cell contact sites—to organize actin filaments and maintain cellular polarity; disruption of FAT1 expression leads to disorganized F‐actin, perturbed cell junctions, and increased migration and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In addition, loss-of-function mutations or downregulation of FAT1 are frequently observed in a variety of malignancies—and in some cases in pre–B cell acute lymphoblastic leukemia where high FAT1 levels correlate with poorer prognosis—underscoring its role in tumor suppression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in renal cells, loss of FAT1 disrupts podocyte adhesion and tubular cell migration, contributing to defects in glomerular filtration and renal tubulopathy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In osteosarcoma, a circular RNA generated from FAT1 (circFAT1) has been shown to act as an oncogene through regulation of microRNA-mediated control of YAP1, thereby promoting tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Finally, functional assays in acute myeloid leukemia further support a tumor-suppressive role for FAT1, wherein its disruption contributes to disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies position FAT1 as a pivotal regulator of cellular adhesion, migration, and signaling—functions that are essential both for normal tissue morphogenesis and for the suppression of malignant transformation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Modulation of FAT1 function or expression may therefore represent a promising therapeutic avenue in multiple cancer types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Luc G T Morris, Andrew M Kaufman, Yongxing Gong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.2538"}], "href": "https://doi.org/10.1038/ng.2538"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23354438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23354438"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaoling Hu, Yuanfang Zhai, Pengzhou Kong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAT1 prevents epithelial mesenchymal transition (EMT) via MAPK/ERK signaling pathway in esophageal squamous cell cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2017.03.033"}], "href": "https://doi.org/10.1016/j.canlet.2017.03.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28366557"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28366557"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yukiko Nishikawa, Tatsuhiko Miyazaki, Koh-Ichi Nakashiro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of β-catenin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2011.1324"}], "href": "https://doi.org/10.3892/or.2011.1324"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21617878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21617878"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Takuji Tanoue, Masatoshi Takeichi "}, {"type": "b", "children": [{"type": "t", "text": "Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200403006"}], "href": "https://doi.org/10.1083/jcb.200403006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15148305"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15148305"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "De-Chen Lin, Jia-Jie Hao, Yasunobu Nagata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic and molecular characterization of esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.2935"}], "href": "https://doi.org/10.1038/ng.2935"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24686850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24686850"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ievgenia Pastushenko, Federico Mauri, Yura Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41586-020-03046-1"}], "href": "https://doi.org/10.1038/s41586-020-03046-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33328637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33328637"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "C E de Bock, A Ardjmand, T J Molloy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/leu.2011.319"}], "href": "https://doi.org/10.1038/leu.2011.319"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22116550"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22116550"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Heon Yung Gee, Carolin E Sadowski, Pardeep K Aggarwal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAT1 mutations cause a glomerulotubular nephropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms10822"}], "href": "https://doi.org/10.1038/ncomms10822"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26905694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26905694"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Gang Liu, Kangmao Huang, Zhiwei Jie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircFAT1 sponges miR-375 to promote the expression of Yes-associated protein 1 in osteosarcoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-018-0917-7"}], "href": "https://doi.org/10.1186/s12943-018-0917-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30514309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30514309"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Manoj Garg, Yasunobu Nagata, Deepika Kanojia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2015-05-646240"}], "href": "https://doi.org/10.1182/blood-2015-05-646240"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26438511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26438511"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "J-B Cazier, S R Rao, C M McLean, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms4756"}], "href": "https://doi.org/10.1038/ncomms4756"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24777035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24777035"}]}]}]}
Synonyms	CDHR8, CDHF7, HFAT1, ME5
Proteins	FAT1_HUMAN
NCBI Gene ID	2195
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FAT1 has 12,999 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 122 datasets.

Click the + buttons to view associations for FAT1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FAT1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FAT1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of FAT1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FAT1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FAT1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of FAT1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FAT1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving FAT1 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of FAT1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FAT1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FAT1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of FAT1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FAT1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FAT1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with FAT1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FAT1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FAT1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FAT1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FAT1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with FAT1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FAT1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FAT1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing FAT1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FAT1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FAT1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of FAT1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FAT1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with FAT1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with FAT1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with FAT1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of FAT1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FAT1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving FAT1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with FAT1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FAT1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FAT1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FAT1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FAT1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FAT1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FAT1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of FAT1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.