FBP1 Gene

Name	fructose-1,6-bisphosphatase 1
Description	Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Fructose‐1,6‐bisphosphatase 1 (FBP1) is a key gluconeogenic enzyme that catalyzes the hydrolysis of fructose 1,6‐bisphosphate to fructose 6‐phosphate, thereby opposing glycolysis. In several cancer types, including clear cell renal cell carcinoma, gastric, liver, colon, and pancreatic cancers, FBP1 is frequently downregulated through mechanisms such as promoter methylation and NF‑κB activation; its loss facilitates a glycolytic (Warburg) phenotype that promotes tumor growth and aggressiveness."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": " In clear cell RCC, for example, FBP1 not only restricts glycolytic flux but also directly impairs hypoxia‐inducible factor (HIF) activity, thereby acting as a unique tumor suppressor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the nervous system, defective parkin function leads to FBP1 accumulation, linking impaired FBP1 regulation to neurodegenerative events in Parkinson’s disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, FBP1 activity is modulated post‐translationally; for instance, ULK1/2 kinases phosphorylate FBP1 during nutrient deprivation, thus diminishing its gluconeogenic function to reroute glucose metabolites toward the pentose phosphate pathway for redox balance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In addition, USP22 regulates the ubiquitination status of FBP1 and thereby influences cell cycle progression via effects on p21 expression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", while suppression of FBP1 in hematopoietic progenitor cells enhances glycolysis and supports ex vivo expansion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Collectively, FBP1 functions as a metabolic gatekeeper by balancing glycolysis and gluconeogenesis; its inactivation or misregulation contributes to tumor progression, altered cellular proliferation, and metabolic dysregulation across diverse biological systems.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bo Li, Bo Qiu, David S M Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fructose-1,6-bisphosphatase opposes renal carcinoma progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature13557"}], "href": "https://doi.org/10.1038/nature13557"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25043030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25043030"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "X Liu, X Wang, J Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2009.332"}], "href": "https://doi.org/10.1038/onc.2009.332"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19881551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19881551"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mingquan Chen, Jianbin Zhang, Ning Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Promoter hypermethylation mediated downregulation of FBP1 in human hepatocellular carcinoma and colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0025564"}], "href": "https://doi.org/10.1371/journal.pone.0025564"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22039417"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22039417"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hidenari Hirata, Keishi Sugimachi, Hisateru Komatsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-15-2601"}], "href": "https://doi.org/10.1158/0008-5472.CAN-15-2601"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27197151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27197151"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yi Zhu, Minmin Shi, Hao Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.4167"}], "href": "https://doi.org/10.18632/oncotarget.4167"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26068981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26068981"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Han Seok Ko, Yunjong Lee, Joo-Ho Shin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1006083107"}], "href": "https://doi.org/10.1073/pnas.1006083107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20823226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20823226"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Fuming Li, Peiwei Huangyang, Michelle Burrows, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41556-020-0511-2"}], "href": "https://doi.org/10.1038/s41556-020-0511-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32367049"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32367049"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Boyko S Atanassov, Sharon Y R Dent "}, {"type": "b", "children": [{"type": "t", "text": "USP22 regulates cell proliferation by deubiquitinating the transcriptional regulator FBP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/embor.2011.140"}], "href": "https://doi.org/10.1038/embor.2011.140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21779003"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21779003"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Laura Braccini, Elisa Ciraolo, Carlo C Campa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms8400"}], "href": "https://doi.org/10.1038/ncomms8400"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26100075"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26100075"}]}]}]}
Synonyms	FBP
Proteins	F16P1_HUMAN
NCBI Gene ID	2203
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FBP1 has 7,882 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 122 datasets.

Click the + buttons to view associations for FBP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FBP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FBP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of FBP1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FBP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FBP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FBP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of FBP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FBP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FBP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FBP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FBP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with FBP1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FBP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FBP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FBP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FBP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with FBP1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with FBP1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FBP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FBP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FBP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FBP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of FBP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FBP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with FBP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with FBP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FBP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with FBP1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FBP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FBP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FBP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FBP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for FBP1 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FBP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FBP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of FBP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing FBP1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with FBP1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with FBP1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of FBP1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with FBP1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.